Inhibition of nerve growth factor‐induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

1987 • 947 citations

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988 • 384 citations

K-252a, a potent inhibitor of protein kinase C from microbial origin.

1986 • 332 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

Ecto-protein kinase activity on the external surface of neural cells

1986 • 173 citations

Inhibitors of calmodulin and protein kinase C block different phases of hippocampal long-term potentiation

1988 • 153 citations

K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

1986 • 139 citations

K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells.

1988 • 115 citations

The Mechanism of Action of Nerve Growth Factor

1991 • 102 citations

Purification and mechanism of activation of a nerve growth factor-sensitive S6 kinase from PC12 cells.

1987 • 92 citations

K-252a, a novel microbial product, inhibits smooth muscle myosin light chain kinase.

1988 • 91 citations

A Novel, Carbohydrate Signal-Mediated Cell Surface Protein Phosphorylation: Ganglioside GQ1b Stimulates Ecto-Protein Kinase Activity on the Cell Surface of a Human Neuroblastoma Cell Line, GOTO2

1988 • 88 citations

K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells

1989 • 71 citations

Evidence for Ecto-Protein Kinase Activity That Phosphorylates Kemptide in a Cyclic AMP-dependent Mode

1989 • 67 citations

K252a is a potent and selective inhibitor of phosphorylase kinase

1990 • 63 citations

Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons

1990 • 52 citations

Functional synapse formation between cultured neurons of rat cerebral cortex. Block by a protein kinase inhibitor which does not permeate the cell membrane.

1988 • 49 citations

Selective Inhibition of Nerve Growth Factor‐Stimulated Protein Kinases by K‐252a and 5′‐S‐Methyladenosine in PC12 Cells

1989 • 45 citations

Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells

1988 • 44 citations

K-252b Is a Selective and Nontoxic Inhibitor of Nerve Growth Factor Action on Cultured Brain Neurons

1991 • 39 citations

Protein kinase activity associated with the surface of guinea pig macrophages.

1978 • 38 citations

Ecto-protein kinase activity of fibroblasts

1979 • 36 citations

Phosphorylation of external cell-surface proteins by an endogenous ecto-protein kinase of goat epididymal intact spermatozoa

1986 • 35 citations

A Nerve Growth Factor‐Sensitive S6 Kinase in Cell‐Free Extracts from PC 12 Cells

1986 • 29 citations

K-252a specifically inhibits the survival and morphological differentiation of NGF-dependent neurons in primary cultures of human dorsal root ganglia

1989 • 28 citations

The roles of macromolecular synthesis and phosphorylation in the regulation of a protein kinase activity transiently stimulated by nerve growth factor

1991 • 25 citations

The effect of K-252a, a potent microbial inhibitor of protein kinase, on activated cyclic nucleotide phosphodiesterase

1988 • 19 citations

Basic fibroblast growth factor is a substrate for phosphorylation by human neutrophil ecto-protein kinase activity

1991 • 19 citations

Nerve Growth Factor and Other Factors Acting on the Nervous System

1983 • 6 citations

Chick sympathetic neurons in culture respond differentially to nerve growth factor and conditioned medium from activated splenic lymphocytes

1991 • 4 citations