Possible Role of Extracellular ATP in Cell-Cell Interactions Leading to CTL-Mediated Cytotoxicity

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

1987 • 407 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Perforin-Mediated Target Cell Lysis by Cytolytic T Lymphocytes

1990 • 268 citations

Serine esterase in cytolytic T lymphocytes

1986 • 240 citations

Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP.

1990 • 198 citations

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

1987 • 196 citations

Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages

1991 • 195 citations

Responses of mouse lymphocytes to extracellular adenosine 5'-triphosphate (ATP). Lymphocytes with cytotoxic activity are resistant to the permeabilizing effects of ATP.

1989 • 178 citations

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

1987 • 174 citations

Responses of mouse lymphocytes to extracellular ATP. II. Extracellular ATP causes cell type-dependent lysis and DNA fragmentation.

1990 • 158 citations

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.

1987 • 128 citations

Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes.

1987 • 109 citations

The biological actions of extracellular ATP

1989 • 96 citations

Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor-triggered cytotoxic T lymphocyte activation pathway.

1988 • 92 citations

Reciprocal control of membrane permeability of transformed cultures of mouse cell lines by external and internal ATP.

1979 • 89 citations

Lymphocyte-triggered internal target disintegration

1991 • 75 citations

Biochemical and functional properties of serine esterases in acidic cytoplasmic granules of cytotoxic T lymphocytes.

1987 • 70 citations

Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes

1987 • 70 citations

Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH.

1991 • 63 citations

A novel cytotoxic T lymphocyte activation assay

1987 • 62 citations

Perforin-induced pore formation

1991 • 61 citations

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells

1978 • 54 citations

Cytolytic T-cell melodrama

1987 • 51 citations

Are lytic granules and perforin 1 involved in lysis induced by in vivo-primed peritoneal exudate cytolytic T lymphocytes?

1987 • 37 citations

Mechanistic, Functional and Immunopharmacological Implications of Biochemical Studies of Antigen Receptor-Triggered Cytolytic T-Lymphocyte Activation*

1988 • 35 citations