Autoimmune tolerance and Type 1 (insulin-dependent) diabetes mellitus

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Transgenic Mice and Analysis of B-Cell Tolerance

1992 • 362 citations

Peripheral deletion of self-reactive B cells

1991 • 353 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

The molecular and cellular basis of affinity maturation in the antibody response

1992 • 278 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

1989 • 245 citations

Peripheral T Cell Tolerance

1992 • 223 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

The Evolution of B-Cell Clones

1990 • 185 citations

The induction of skin graft tolerance in major histocompatibility complex‐mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti‐CD4 and anti‐CD8 antibodies

1990 • 157 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme lgM/lgD transgenic mice

1992 • 147 citations

Clonal Deletion of Autospecific B Lymphocytes

1991 • 137 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

1991 • 107 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

1991 • 97 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

A Transgenic Approach to the Study of Peripheral T‐Cell Tolerance

1991 • 54 citations

New perspectives on immunointervention in autoimmune diseases

1990 • 49 citations

Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation.

1992 • 43 citations

Peripheral Tolerance in Transgenic Mice: Tolerance to Class II MHC and non‐MHC Transgene Antigens

1991 • 38 citations

A nondeletional mechanism of peripheral tolerance in T-cell receptor transgenic mice.

1991 • 34 citations

Memory cell generation ablated by soluble protein antigen by means of effects on T- and B-lymphocyte compartments.

1992 • 23 citations