Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury
Data up to Jan 2025
Total Citations Per Year
Abstract
References (60)
Arzneimittelforschung
2005 • 8,820 citations
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
1986 • 1,842 citations
Cell Damage in the Brain: A Speculative Synthesis
1981 • 1,827 citations
Memory and Brain
1987 • 1,821 citations
Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury
1987 • 1,821 citations
Ionic dependence of glutamate neurotoxicity
1987 • 1,811 citations
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
1988 • 1,745 citations
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
1989 • 1,505 citations
Calcium Dependence of Toxic Cell Death: A Final Common Pathway
1979 • 1,478 citations
Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model
1989 • 1,126 citations
A fluid percussion model of experimental brain injury in the rat
1987 • 1,031 citations
Role of Ca2+ in toxic cell killing
1989 • 856 citations
Calcium and Ischemic Injury
1986 • 529 citations
Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations
1989 • 450 citations
Historical Overview
1988 • 428 citations
Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat
1990 • 411 citations
Central nervous system trauma status report—1985
1987 • 382 citations
The molecular basis of brain injury and brain edema
1990 • 355 citations
Evaluation of Memory Dysfunction Following Experimental Brain Injury Using the Morris Water Maze
1991 • 352 citations
Synthesis of Compounds with Properties of Leukotrienes C 4 and D 4 in Gerbil Brains After Ischemia and Reperfusion
1984 • 350 citations
The Molecular Basis of Brain Injury and Brain Edema: The Role of Oxygen Free Radicals
1990 • 321 citations
Increased vulnerability of the midly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury
1989 • 277 citations
Long-term potentiation: from biophysics to behavior
1988 • 238 citations
Traumatic Brain Injury in the Rat: Characterization of a Midline Fluid-Percussion Model
1987 • 224 citations
Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres
1989 • 216 citations
The Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats
1988 • 183 citations
Effects of theN-Methyl-<scp>d</scp>-Aspartate Receptor Blocker MK-801 on Neurologic Function After Experimental Brain Injury
1989 • 183 citations
Effect of Noncompetitive Blockade of N‐Methyl‐d‐Aspartate Receptors on the Neurochemical Sequelae of Experimental Brain Injury
1990 • 166 citations
Memory Storage and Neural Systems
1989 • 155 citations
Calcium channels and calcium channel antagonists
1987 • 141 citations
(S)‐Emopamil, a novel calcium channel blocker and serotonin S 2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in the rat
1988 • 139 citations
Relationship between body and brain temperature in traumatically brain-injured rodents
1991 • 126 citations
Development of Prolonged Focal Cerebral Edema and Regional Cation Changes Following Experimental Brain Injury in the Rat
1992 • 120 citations
Effects of Traumatic Brain Injury on Cerebral High-Energy Phosphates and pH: A31P Magnetic Resonance Spectroscopy Study
1987 • 119 citations
Regional brain metabolite levels following mild experimental head injury in the cat
1985 • 109 citations
A trial of the effect of nimodipine on outcome after head injury
1991 • 99 citations
Changes in Cellular Bioenergetic State Following Graded Traumatic Brain Injury in Rats: Determination by Phosphorus 31 Magnetic Resonance Spectroscopy
1988 • 97 citations
Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury
1985 • 85 citations
Regulation of short-term associative memory by calcium-dependent protein kinase
1990 • 70 citations
Nimodipine Pretreatment Improves Cerebral Blood Flow and Reduces Brain Edema in Conscious Rats Subjected to Focal Cerebral Ischemia
1990 • 61 citations
The Role of Calcium in Spinal Cord Injury
1985 • 56 citations
Blood-brain barrier sodium transport limits development of brain edema during partial ischemia in gerbils.
1989 • 53 citations
Norepinephrine and Serotonin Release upon Impact Injury to Rat Spinal Cord
1990 • 51 citations
Nicardipine reduces ischemic brain injury. Magnetic resonance imaging/spectroscopy study in cats.
1989 • 50 citations
Brain injury from marked hypoxia in cats: role of hypotension and hyperglycemia.
1985 • 44 citations
A double blind placebo controlled trial of the calcium entry blocking drug, nicardipine, in the treatment of vasospasm following severe head injury
1990 • 41 citations
Recovery of function after brain damage: Facilitation by the calcium entry blocker nimodipine.
1989 • 41 citations
Recovery of function after brain damage: Facilitation by the calcium entry blocker nimodipine.
1989 • 40 citations
Degeneration of neurons in the thalamic reticular nucleus following transient ischemia due to raised intracranial pressure: excitotoxic degeneration mediated via non-NMDA receptors?
1989 • 39 citations
Ca Paradox in Neural Injury: A Hypothesis
1986 • 38 citations
Effect of the Serotonin Antagonist Ketanserin on the Hemodynamic and Morphological Consequences of Thrombotic Infarction
1989 • 32 citations
Neurologic Deficit and Cerebral ATP Depletion after Temporary Focal Ischemia in Cats
1984 • 27 citations
Effect of enhanced capillary activity on the blood-brain barrier during focal cerebral ischemia in cats.
1989 • 25 citations
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile.
1989 • 24 citations
Treatment of cerebral vasospasm following severe head injury with the calcium influx blocker nimodipine
1985 • 24 citations
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 3rd communication: effect on postischemic cerebral blood flow and metabolism, and ischemic neuronal cell death.
1989 • 23 citations
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 2nd communication: brain penetration, cerebral vascular and metabolic effects.
1989 • 23 citations
The Ca2+ channel and 5-HT2 receptor antagonist (s)-emopamil in cerebral ischaemia
1989 • 17 citations
Protective action of calcium channel blockers on Na+, K+ –ATPase in gerbil cerebral cortex following ischemia
1988 • 16 citations
Vascular and Direct Effects on Cerebral Energy Metabolism of Emopamil
1989 • 3 citations