Clinical Neuro-Protection Trials in Severe Traumatic Brain Injury: Lessons from Previous Studies

Traumatic brain injury in the rat: Characterization of a lateral fluid-percussion model

1989 • 1,126 citations

A fluid percussion model of experimental brain injury in the rat

1987 • 1,031 citations

High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury

1988 • 591 citations

EXPERIMENTAL CEREBRAL CONCUSSION

1941 • 551 citations

The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report

1993 • 534 citations

Axonal Change in Minor Head Injury

1983 • 435 citations

Failure of prophylactic barbiturate coma in the treatment of severe head injury

1985 • 352 citations

Traumatically Induced Altered Membrane Permeability: Its Relationship to Traumatically Induced Reactive Axonal Change

1994 • 316 citations

Animate Models of Human Head Injury

1994 • 278 citations

The University of Toronto Head Injury Treatment Study: A Prospective, Randomized Comparison of Pentobarbital and Mannitol

1984 • 264 citations

Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a Phase II trial

1993 • 234 citations

Traumatic subarachnoid hemorrhage and its treatment with nimodipine

1996 • 192 citations

Head Injury in Man and Experimental Animals: Neuropathology

1983 • 191 citations

Brain Oxygen, CO2, pH, and Temperature Monitoring

1995 • 165 citations

Experimental Models of Brain Injury

1989 • 160 citations

Use of transcranial Doppler sonography to predict development of a delayed ischemic deficit after subarachnoid hemorrhage

1993 • 141 citations

Effect of THAM upon outcome in severe head injury: a randomized prospective clinical trial

1993 • 121 citations

Protective effect of Fluosol-DA in acute cerebral ischemia.

1981 • 120 citations

The kallikrein-kinin system as mediator in vasogenic brain edema

1984 • 109 citations

Cerebral Concussion in the Monkey: An Experimental Model

1966 • 106 citations

The kallikrein-kinin system as mediator in vasogenic brain edema

1984 • 105 citations

Therapeutic Hypothermia Is Cytoprotective without Attenuating the Traumatic Brain Injury-Induced Elevations in Interstitial Concentrations of Aspartate and Glutamate

1993 • 102 citations

Treatment of patients with severe head injury by triamcinolone: a prospective, controlled multicenter clinical trial of 396 cases

1995 • 99 citations

The kallikrein-kinin system as mediator in vasogenic brain edema

1986 • 95 citations

NINDS Traumatic Coma Data Bank: intracranial pressure monitoring methodology

1991 • 90 citations

Resuscitative hypothermia

1996 • 89 citations

Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents

1991 • 85 citations

Relationship between Glasgow Outcome Scale and Neuropsychological Measures after Brain Injury

1993 • 64 citations

Pitfalls and Advances from the International Tirilazad Trial in Moderate and Severe Head Injury

1995 • 37 citations

A use-dependent sodium channel antagonist, 619C89, in reduction of ischemic brain damage and glutamate release after acute subdural hematoma in the rat

1996 • 31 citations

Clinical Trials with Dismutec™ (Pegorgotein; Polyethylene Glycol-Conjugated Superoxide Dismutase; PEG-SOD) in the Treatment of Severe Closed Head Injury

1994 • 28 citations

Relationship between Glasgow Outcome Scale and Neuropsychological Measures after Brain Injury

1993 • 20 citations

Excitotoxic damage in neurotrauma: fact or fiction

1996 • 19 citations

Brain Oxygen, CO2, pH, and Temperature Monitoring

1995 • 16 citations