Brain-derived neurotrophic factor (bdnf) can prevent apoptosis of rat cerebellar granule neurons in culture

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN

1969 • 920 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures

1984 • 408 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

1993 • 333 citations

The trk B tyrosine protein kinase is a receptor for neurotrophin-4

1992 • 326 citations

Chromosomal Translocations in Lymphoid Malignancies Reveal Novel Proto-Oncogenes

1992 • 267 citations

Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations.

1978 • 246 citations

The effect of potassium on neuronal differentiation in cultures of dissociated newborn rat cerebellum

1972 • 244 citations

Changes in neurotrophin responsiveness during the development of cerebellar granule neurons

1992 • 240 citations

Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats

1988 • 208 citations

Cloning and expression of a cDNA encoding a novel human neurotrophic factor

1990 • 199 citations

Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere

1993 • 73 citations

Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells

1993 • 59 citations

Brain-Derived Neurotrophic Factor: An NGF-Related Neurotrophin

1993 • 49 citations

Characterization and crystallization of recombinant human neurotrophin-4.

1994 • 42 citations