Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

Reinstatement of cocaine-reinforced responding in the rat

1981 • 936 citations

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

1992 • 827 citations

Nicotine activates and desensitizes midbrain dopamine neurons

1997 • 762 citations

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

1994 • 741 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

Nicotine maintains robust self-administration in rats on a limited-access schedule

1989 • 586 citations

Animal models of drug craving

1993 • 560 citations

The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

1983 • 457 citations

The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity

1992 • 428 citations

Functional characterization of agonists at recombinant human 5‐HT_2A, 5‐HT_2B and 5‐HT_2C receptors in CHO‐K1 cells

1999 • 347 citations

Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat

2000 • 333 citations

5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.

1998 • 324 citations

Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.

1988 • 313 citations

Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording

1989 • 291 citations

Selective dopamine antagonists reduce nicotine self-administration

1991 • 279 citations

Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

1998 • 278 citations

Fluoxetine reduces intravenous cocaine self-administration in rats

1990 • 254 citations

SB 242 084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system

1999 • 244 citations

Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats

1997 • 240 citations

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

2000 • 209 citations

Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat

1991 • 182 citations

Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin2C receptors

2000 • 179 citations

Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area

1995 • 179 citations

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen

1990 • 162 citations

Locomotor activity in rats after administration of nicotinic agonists intracerebrally

1990 • 158 citations

Response of nicotine self-administration in the rat to manipulations of mu-opioid and γ-aminobutyric acid receptors in the ventral tegmental area

2000 • 154 citations

Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat

2000 • 145 citations

Reinstatement and spontaneous recovery of nicotine seeking in rats

1997 • 142 citations

On the Relationships Between the Striatum and the Pedunculopontine Tegmental Nucleus

1997 • 135 citations

m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors

2001 • 124 citations

5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists

1997 • 122 citations

The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study

2000 • 118 citations

Comparative effects of continuous infusion of mCPP, Ro 60‐0175 and d‐fenfluramine on food intake, water intake, body weight and locomotor activity in rats

2000 • 79 citations

Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule induced self injection of nicotine in the rat

1982 • 78 citations

Behavioral sensitization to nicotine is associated with behavioral disinhibition; counteraction by citalopram

1999 • 59 citations

Effects of RO 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety

2000 • 57 citations

Influence of 5-HT3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats

1994 • 54 citations

Nicotine-induced Fos expression in the pedunculopontine mesencephalic tegmentum in the rat

2000 • 37 citations

Tolerance to the anxiogenic-like effect of mCPP in the rat elevated zero-maze test after subchronic administration

2000 • 1 citations