Increased Mature Interleukin-1β (IL-1β) Secretion from THP-1 Cells Induced by Nigericin Is a Result of Activation of p45 IL-1β-converting Enzyme Processing

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

1994 • 725 citations

Simple and rapid fluorimetric method for DNA microassay

1977 • 491 citations

Potassium-inhibited processing of IL-1 beta in human monocytes.

1995 • 282 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

1997 • 243 citations

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.

1992 • 137 citations

IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor.

1994 • 113 citations

Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1β-converting Enzyme Precursor

1995 • 107 citations

Induction of Rapid IL-β mRNA Degradation in THP-1 Cells Mediated Through the AU-Rich Region in the 3′UTR by a Radicicol Analogue

1996 • 50 citations

Inhibition of interleukin-1 release by IX 207-887

1990 • 18 citations

Effects of intracellular ions on interleukin-1 beta production by lipopolysaccharide-activated human monocytes

1992 • 7 citations