Specificity of Serine Proteinase/Serpin Complex Binding to Very-Low-Density Lipoprotein Receptor and alpha2-Macroglobulin Receptor/Low-Density-Lipoprotein-Receptor-Related Protein

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Plasminogen activator inhibitors

1987 • 957 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

1994 • 879 citations

Human leukocyte granule elastase: rapid isolation and characterization

1976 • 550 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

1992 • 466 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

Human Apolipoprotein E Receptor 2

1996 • 378 citations

Biological and clinical aspects of plasminogen activator inhibitor type 2

1995 • 324 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.

1992 • 318 citations

Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

1994 • 266 citations

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1992 • 244 citations

Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family.

1994 • 241 citations

Enhancement of the Binding of Triglyceride-rich Lipoproteins to the Very Low Density Lipoprotein Receptor by Apolipoprotein E and Lipoprotein Lipase

1995 • 224 citations

Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin

1991 • 217 citations

Clearance of Thrombin from Circulation in Rabbits by High-affinity Binding Sites on Endothelium

1980 • 204 citations

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes.

1990 • 190 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

1994 • 177 citations

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

1995 • 171 citations

Cellular Internalization and Degradation of Antithrombin III-Thrombin, Heparin Cofactor II-Thrombin, and α1-Antitrypsin-Trypsin Complexes Is Mediated by the Low Density Lipoprotein Receptor-related Protein

1996 • 159 citations

The Very Low Density Lipoprotein Receptor Mediates the Cellular Catabolism of Lipoprotein Lipase and Urokinase-Plasminogen Activator Inhibitor Type I Complexes

1995 • 153 citations

Receptor‐mediated endocytosis of plasminogen activators and activator/inhibitor complexes

1994 • 148 citations

The receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands

1994 • 136 citations

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.

1994 • 135 citations

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.

1994 • 135 citations

Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport.

1995 • 130 citations

Characterization and tissue-specific expression of the human ‘very low density lipoprotein (VLDL) receptor’ mRNA

1994 • 129 citations

Endocytosis and degradation of alpha 1-antitrypsin-protease complexes is mediated by the serpin-enzyme complex (SEC) receptor.

1990 • 121 citations

Monoclonal Antibodies to Human 54,000 Molecular Weight Plasminogen Activator Inhibitor from Fibrosarcoma Cells - Inhibitor Neutralization and One-Step Affinity Purification

1986 • 120 citations

Expression of the VLDL Receptor in Endothelial Cells

1996 • 119 citations

Expression of the Very Low-Density Lipoprotein Receptor (VLDL-r), an Apolipoprotein-E Receptor, in the Central Nervous System and in Alzheimerʼs Disease

1996 • 114 citations

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats

1993 • 112 citations

Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor Complex

1995 • 112 citations

Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.

1990 • 111 citations

The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes

1991 • 106 citations

A New Low Density Lipoprotein Receptor Homologue with 8 Ligand Binding Repeats in Brain of Chicken and Mouse

1996 • 106 citations

Heparin Binding by Fibronectin Module III-13 Involves Six Discontinuous Basic Residues Brought Together to Form a Cationic Cradle

1995 • 103 citations

Heparin binding to protein C inhibitor.

1992 • 102 citations

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas

1996 • 102 citations

Review

1996 • 96 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

Protease nexin-1-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and alpha 2-macroglobulin receptor.

1994 • 85 citations

In vivo catabolism of α1-proteinase inhibitor-trypsin, antithrombin III-thrombin and α2-macroglobulin-methylamine

1982 • 80 citations

Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry.

1996 • 74 citations

Plasminogen Activator Inhibitor-1 and Vitronectin Promote the Cellular Clearance of Thrombin by Low Density Lipoprotein Receptor-related Proteins 1 and 2

1996 • 72 citations

Properties of Three Different Molecular Forms of the α₂Plasmin Inhibitor

1981 • 71 citations

Protease nexins: Cell‐secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases

1983 • 66 citations

Differential Recognition of α1-Antitrypsin-Elastase and α1-Antichymotrypsin-Cathepsin G Complexes by the Low Density Lipoprotein Receptor-related Protein

1995 • 65 citations

Coagulation factors and their inhibitors

1994 • 65 citations

Purification and characterization of a plasminogen activator from mouse cells transformed by an oncogenic virus

1980 • 64 citations

Structural aspects of serpin inhibition

1994 • 64 citations

Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT.

1993 • 63 citations

Elucidation of structural requirements on plasminogen activator inhibitor 1 for binding to heparin.

1992 • 62 citations

LDL receptor-related protein (LRP): a multiligand receptor

1994 • 62 citations

In vivo catabolism of α1-antichymotrypsin is mediated by the Serpin receptor which binds α1-proteinase inhibitor, antithrombin III and heparin cofactor II

1988 • 59 citations

Human Very-Low-Density Lipoprotein Receptor Complementary DNA and Deduced Amino Acid Sequence and Localization of Its Gene (VLDLR) to Chromosome Band 9p24 by Fluorescence in Situ Hybridization

1994 • 54 citations

3 Receptors for plasminogen and t-PA: an update

1995 • 53 citations

The Multiligand α₂‐Macroglobulin Receptor/Low Density Lipoprotein Receptor‐Related Protein (α₂MR/LRP)

1994 • 52 citations

Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M_r, 40,000 receptor associated protein

1994 • 49 citations

Lipid Accumulation and Foam Cell Formation in Chinese Hamster Ovary Cells Overexpressing Very Low Density Lipoprotein Receptor

1995 • 49 citations

A Unique Pathway for the Plasma Elimination of α2-Antiplasmin-Protease Complexes in Mice

1982 • 40 citations

In vivo catabolism of heparin cofactor II and its complex with thrombin: Evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors

1988 • 39 citations

Breast Carcinoma Epithelial Cells Express a Very Low‐Density Lipoprotein Receptor Variant Lacking the O‐Linked Glycosylation Domain Encoded by Exon 16, But with Full Binding Activity for Serine Proteinase/Serpin Complexes and M_r‐40000 Receptor‐Associated Protein

1997 • 35 citations

Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport

1995 • 33 citations

The Isoforms of Human Neutrophil Elastase and Cathepsin G Differ in their Carbohydrate Side Chain Structures

1993 • 32 citations

A Polyvalent Proteinase Inhibitor from Horse‐Blood‐Leucocyte Cytosol

1977 • 25 citations

[LDL-receptor-related protein].

1994 • 20 citations

Isolation of Nine Human Plasma Proteinase Inhibitors by Sequential Affinity Chromatography

1990 • 20 citations

Monoclonal Antibodies Against the Heparin- Dependent Protein C Inhibitor Suitable for Inhibitor Purification and Assay of Inhibitor Complexes

1988 • 19 citations

Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of α2-macroglobulin receptor and urokinase receptor expression

1995 • 17 citations

Receptor-Mediated Endocytosis of Thrombin-Antithrombin III Complex by the Human Monocytoid Cell Line U937

1994 • 4 citations

Biology of vitronectins and their receptors : proceedings of the First International Vitronectin Workshop, Rauischholzhausen Castle, Marburg, Germany, 25-28 August, 1993

1993 • 2 citations