Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Atherogenesis: a postprandial phenomenon.

1979 • 1,713 citations

Fast and sensitive multiple sequence alignments on a microcomputer

1989 • 1,245 citations

The Use of Antiavidin Antibody and Avidin-Biotin-Peroxidase Complex in Immunoperoxidase Technics

1981 • 1,067 citations

Lipoprotein Lipase

1989 • 970 citations

The Isoenzymes of Glutathione Transferase

1985 • 960 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.

1991 • 669 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages

1980 • 543 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.

1983 • 396 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

1992 • 341 citations

Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit

1986 • 335 citations

Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein.

1990 • 300 citations

Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

1994 • 266 citations

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

1995 • 259 citations

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1992 • 244 citations

Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen

1991 • 230 citations

Enhancement of the Binding of Triglyceride-rich Lipoproteins to the Very Low Density Lipoprotein Receptor by Apolipoprotein E and Lipoprotein Lipase

1995 • 224 citations

Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes.

1994 • 223 citations

Bovine aortic endothelial cells display macrophage-like properties towards acetylated 125I-labelled low density lipoprotein

1980 • 212 citations

Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells.

1978 • 177 citations

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

1994 • 177 citations

Postprandial triglyceridemia and carotid atherosclerosis in middle-aged subjects.

1992 • 173 citations

Binding of lipoprotein lipase to endothelial cells in culture.

1981 • 164 citations

The Very Low Density Lipoprotein Receptor Mediates the Cellular Catabolism of Lipoprotein Lipase and Urokinase-Plasminogen Activator Inhibitor Type I Complexes

1995 • 153 citations

Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.

1994 • 140 citations

Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport.

1995 • 130 citations

Characterization and tissue-specific expression of the human ‘very low density lipoprotein (VLDL) receptor’ mRNA

1994 • 129 citations

Regulation of the very low density lipoprotein receptor by thyroid hormone in rat skeletal muscle

1994 • 127 citations

Postprandial Triglyceride Response in Young Adult Men and Familial Risk for Coronary Atherosclerosis

1994 • 125 citations

The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors

1995 • 121 citations

Mouse Very‐Low‐Density‐Lipoprotein Receptor (VLDLR) cDNA Cloning, Tissue‐specific Expression and Evolutionary Relationship with the Low‐density‐lipoprotein Receptor

1994 • 105 citations

Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima.

1988 • 100 citations

LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells.

1984 • 98 citations

Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23

1993 • 98 citations

Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling.

1990 • 92 citations

Low density lipoprotein metabolism by endothelial cells from human umbilical cord arteries and veins.

1983 • 82 citations

Lipoprotein and cholesterol metabolism in rabbit arterial endothelial cells in culture

1978 • 77 citations

Effect of the 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat.

1994 • 77 citations

Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.

1994 • 74 citations

Increased synthesis of plasminogen activator inhibitor-1 by cultured human endothelial cells exposed to native and modified LDLs. An LDL receptor-independent phenomenon.

1993 • 73 citations

Expression of urokinase receptors by human trophoblast. A histochemical and ultrastructural analysis.

1994 • 64 citations

A fresh look at the atherogenic remnant hypothesis

1992 • 61 citations

Dyslipoproteinemia and Diabetes

1990 • 58 citations

Human Very-Low-Density Lipoprotein Receptor Complementary DNA and Deduced Amino Acid Sequence and Localization of Its Gene (VLDLR) to Chromosome Band 9p24 by Fluorescence in Situ Hybridization

1994 • 54 citations

Monocyte adherence to endothelial cells in vitro is increased by beta-VLDL.

1987 • 53 citations

Expression of LDL receptor-related protein/alpha 2-macroglobulin receptor in human normal and atherosclerotic arteries.

1994 • 53 citations

Lipid Accumulation and Foam Cell Formation in Chinese Hamster Ovary Cells Overexpressing Very Low Density Lipoprotein Receptor

1995 • 49 citations

Beta-very low density lipoprotein pretreatment of endothelial monolayers increases monocyte adhesion.

1989 • 49 citations

Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M_r, 40,000 receptor associated protein

1994 • 49 citations

Triglyceride-rich lipoproteins and atherosclerosis: pathophysiological considerations.

1994 • 49 citations

In Vitro Injury of Porcine Aortic Endothelial Cells by Very-Low-Density Lipoproteins from Diabetic Rat Serum

1982 • 43 citations

Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats

1984 • 39 citations

Functions of the LDL Receptor Gene Family

1994 • 34 citations

Metabolism of low density lipoprotein by bovine endothelial cells as a function of cell density.

1984 • 24 citations

Hyperinsulinaemia and hypertriglyceridaemia.

1994 • 23 citations

Interactions amongst insulin, lipoproteins and haemostatic function relevant to coronary heart disease.

1994 • 17 citations

Diabetic dyslipidaemia: treatment implications.

1994 • 9 citations

Cellular localization of induced human interferon-? mRNA by non-radioactive in situ hybridization

1989 • 9 citations