The receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

1993 • 1,092 citations

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1973 • 1,062 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

1989 • 680 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats

1983 • 496 citations

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

1992 • 466 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

α ₂ “Macroglobulin, a multifunctional binding protein with targeting characteristics

1992 • 454 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

1991 • 413 citations

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

1987 • 399 citations

Clearance and binding of two electrophoretic “fast” forms of human alpha 2-macroglobulin.

1981 • 398 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

1992 • 341 citations

Evidence that the newly cloned low‐density‐lipoprotein receptor related protein (LRP) is the α₂‐macroglobulin receptor

1990 • 320 citations

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

1989 • 307 citations

Invasion of the trophoblasts

1992 • 305 citations

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

1993 • 297 citations

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.

1990 • 279 citations

Molecular flypaper, host defense, and atherosclerosis. Structure, binding properties, and functions of macrophage scavenger receptors.

1993 • 271 citations

Autoimmune Target in Heymann Nephritis Is a Glycoprotein with Homology to the LDL Receptor

1989 • 268 citations

The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin.

1990 • 268 citations

alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions.

1979 • 232 citations

Demonstration of an alpha2-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines.

1979 • 230 citations

Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen

1991 • 230 citations

Primary amines inhibit recycling of α2M receptors in fibroblasts

1980 • 213 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase

1993 • 200 citations

Towards a better definition of human leucocyte surface molecules

1989 • 198 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein). Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors

1991 • 186 citations

Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans

1993 • 185 citations

The low-density lipoprotein receptor-related protein: double agent or decoy?

1991 • 183 citations

Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.

1987 • 182 citations

The sequence and topology of human complement component C9.

1985 • 179 citations

The Disappearance of Enzyme—Inhibitor Complexes from the Circulation of Man

1976 • 178 citations

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain.

1992 • 177 citations

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes

1993 • 169 citations

How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

1992 • 166 citations

Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane.

1987 • 164 citations

Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney.

1991 • 161 citations

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase.

1992 • 157 citations

How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

1992 • 157 citations

Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo.

1990 • 150 citations

Analysis of macrophage surface receptors. I. Binding of alpha-macroglobulin . protease complexes to rabbit alveolar macrophages.

1979 • 150 citations

Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.

1992 • 147 citations

Analysis of macrophage surface receptors. II. Internalization of alpha-macroglobulin . trypsin complexes by rabbit alveolar macrophages.

1979 • 132 citations

Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. II. Extrarenal distribution.

1986 • 131 citations

Uptake of proteinase-α-macroglobulin complexes by macrophages☆

1975 • 127 citations

The human keratinocyte two‐dimensional gel protein database (update 1992): Towards an integrated approach to the study of cell proliferation, differentiation and skin diseases

1992 • 125 citations

alpha 2-macroglobulin adsorbed to colloidal gold: a new probe in the study of receptor-mediated endocytosis.

1981 • 124 citations

Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro

1993 • 124 citations

Characterization of human pregnancy zone protein. Comparison with human alpha 2-macroglobulin.

1985 • 119 citations

Identification of the rat Heymann nephritis autoantigen (GP330) as a receptor site for plasminogen

1991 • 119 citations

α2-Macroglobulin and Related Thiol Ester Plasma Proteins

1987 • 118 citations

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.

1987 • 115 citations

Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level.

1975 • 112 citations

Purification of the Rat Hepatic α2-Macroglobulin Receptor as an Approximately 440-kDa Single Chain Protein

1989 • 112 citations

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats

1993 • 112 citations

Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.

1990 • 111 citations

Three high molecular weight protease inhibitors of rat plasma. Isolation, characterization, and acute phase changes.

1987 • 110 citations

Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes.

1993 • 106 citations

Post-translational changes in tertiary and quaternary structure of the insulin proreceptor. Correlation with acquisition of function.

1988 • 105 citations

Lipoprotein Lipase

1991 • 105 citations

Binding and internalization of 125I-alpha 2-macroglobulin by cultured fibroblasts.

1981 • 103 citations

The receptor-binding domain of human alpha 2-macroglobulin. Isolation after limited proteolysis with a bacterial proteinase.

1986 • 103 citations

Domain structure of human α₂‐macroglobulin

1986 • 102 citations

Uptake and degradation of α2-macroglobulin-protease complexes in human cells in culture

1978 • 102 citations

Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma.

1993 • 100 citations

Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization.

1991 • 97 citations

Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells.

1993 • 91 citations

Purification of the human placental α₂‐macroglobulin receptor

1989 • 91 citations

Analysis of the effect of amines on inhibition of receptor-mediated and fluid-phase pinocytosis in rabbit alveolar macrophages

1981 • 88 citations

Sequential conformational changes in calmodulin upon binding of calcium

1984 • 85 citations

Lactoferrin specifically inhibits endocytosis of chylomicron remnants but not alpha-macroglobulin.

1992 • 80 citations

Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein.

1993 • 78 citations

The LDL-receptor-related protein ??? portrait of a multifunctional receptor

1993 • 78 citations

Receptor-recognized α2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages

1993 • 77 citations

Cell association and degradation of α2-macroglobulin-trypsin complexes in hepatocytes and adipocytes

1983 • 76 citations

The human alpha 2-macroglobulin receptor contains high affinity calcium binding sites important for receptor conformation and ligand recognition.

1990 • 74 citations

A conserved region in .alpha.-macroglobulins participates in binding to the mammalian .alpha.-macroglobulin receptor

1989 • 72 citations

Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells

1993 • 71 citations

Characteristics of chylomicron remnant uptake into rat liver

1988 • 70 citations

Immunohistochemical study of α2 Macroglobulin receptor in Alzheimer and control postmortem human brain

1993 • 70 citations

Colchicine-induced redistribution of an apical membrane glycoprotein (gp330) in proximal tubules

1989 • 69 citations

A Heparin Binding Protein Whose Expression Increases during Differentiation of Embryonal Carcinoma Cells to Parietal Endoderm Cells: cDNA Cloning and Sequence Analysis1

1990 • 67 citations

Abundance, relative gelation activity, and distribution of the 95,000-dalton actin-binding protein from Dictyostelium discoideum.

1983 • 67 citations

Correction: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

1993 • 65 citations

Recognition of nucleophile-treated alpha 2-macroglobulin by the alveolar macrophage alpha-macroglobulin . protease complex receptor.

1981 • 65 citations

The plasma clearance of human α2-macroglobulin-trypsin complex in the rat is mainly accounted for by uptake into hepatocytes

1985 • 64 citations

Binding of α2-macroglobulin to hepatocytes: Mechanism of in vivo clearance

1985 • 64 citations

Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by proteolytically modified alpha 1 AT.

1993 • 63 citations

Elucidation of structural requirements on plasminogen activator inhibitor 1 for binding to heparin.

1992 • 62 citations

The laying hen expresses two different low density lipoprotein receptor-related proteins.

1991 • 62 citations

Identification of a 400-kd protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis.

1987 • 61 citations

Colony-stimulating factor-1 modulates alpha 2-macroglobulin receptor expression in murine bone marrow macrophages.

1990 • 60 citations

The somatic cell-specific low density lipoprotein receptor-related protein of the chicken. Close kinship to mammalian low density lipoprotein receptor gene family members.

1994 • 58 citations

Immunocytochemical identification of the human α2-macrogiobulin receptor in monocytes and fibroblasts: Monoclonal antibodies define the receptor as a monocyte differentiation antigen

1990 • 57 citations

Regulated expression of the trophoblast alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Differentiation and cAMP modulate protein and mRNA levels.

1992 • 56 citations

Heymann nephritis induced by kidney brush border glycoproteins.

1980 • 55 citations

Detection of two forms of GP330. Their role in Heymann nephritis.

1993 • 54 citations

Insulin increases the cell surface concentration of α2-macroglobulin receptors in 3T3-L1 adipocytes

1989 • 53 citations

Characterization of receptors for α2-macroglobulin-trypsin complex in rat hepatocytes

1986 • 53 citations

Identification and characterization of urokinase receptors in natural killer cells and T‐cell‐derived lymphokine activated killer cells

1992 • 51 citations

Characteristics of the macrophage uptake of proteinase-α-macroglobulin complexes

1976 • 51 citations

Receptors for α2-Macroglobulin- and pregnancy zone protein-proteinase complexes in the human placental syncytiotrophoblast

1988 • 48 citations

Ultrastructure of alpha 2-macroglobulins

1992 • 47 citations

Structure of the low-density lipoprotein receptor-related protein (LRP) promoter

1989 • 47 citations

Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.

1987 • 46 citations

Human pregnancy zone protein and alpha 2-macroglobulin. High-affinity binding of complexes to the same receptor on fibroblasts and characterization by monoclonal antibodies.

1986 • 45 citations

Binding, surface mobility, internalization, and degradation of rhodamine-labeled .alpha.2-macroglobulin

1981 • 43 citations

Location of gp330/alpha 2-m receptor-associated protein (alpha 2-MRAP) and its binding sites in kidney: distribution of endogenous alpha 2-MRAP is modified by tissue processing.

1993 • 43 citations

Co-clustering and internalization of low-density lipoproteins and α2-macroglobulin in human skin fibroblasts

1982 • 40 citations

Analysis of a 45-kDa protein that binds to the Heymann nephritis autoantigen GP330.

1993 • 34 citations

Binding and degradation of α2-macroglobulin by cultured fibroblasts

1980 • 33 citations

Secretion of plasminogen activator and its inhibitor by glomerular epithelial cells

1990 • 32 citations

Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts.

1980 • 32 citations

Binding of alpha-2-macroglobulin trypsin complex to human monocytes in culture

1987 • 32 citations

Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA

1993 • 31 citations

Evidence for binding of human pregnancy zone protein-proteinase complex to α2-macroglobulin receptors

1986 • 31 citations

Proteolysis at a lysine residue abolishes the recetor‐recognition site of α₂‐Macroglobulin complexes

1982 • 28 citations

The gene for the human putative apoE receptor is on chromosome 12 in the segment q13–14

1989 • 27 citations

Binding and receptor-mediated endocytosis of pregnancy zone protein-proteinase complex in rat macrophages

1987 • 27 citations

Modulation of the low-density-lipoprotein-receptor-related protein and its relevance to chylomicron-remnant metabolism

1992 • 27 citations

Distinct properties of the recognition sites for beta-very low density lipoprotein (remnant receptor) and alpha 2-macroglobulin (low density lipoprotein receptor-related protein) on rat parenchymal cells.

1992 • 26 citations

In vivo removal of beta-VLDL, chylomicron remnants, and alpha 2-macroglobulin in the rat.

1993 • 26 citations

Uptake and degradation of insulin and α2-macroglobulin-trypsin complex in rat adipocytes. Evidence for different pathways

1985 • 25 citations

alpha 2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites.

1983 • 24 citations

Image processing of proteinase- and methylamine-transformed human α2-macroglobulin

1989 • 24 citations

Solubilization and affinity purification of the alpha 2-macroglobulin receptor from human fibroblasts.

1984 • 22 citations

Isolation of a 330-kDa glycoprotein from human kidney similar to the Heymann nephritis autoantigen (gp330).

1990 • 22 citations

Characterization, size estimation and solubilization of α-macroglobulin complex receptors in liver membranes

1989 • 22 citations

Binding of .alpha.2-macroglobulin-thrombin complexes and methylamine-treated .alpha.2-macroglobulin to human blood monocytes

1988 • 21 citations

Pre-lysosomal divergence of alpha 2-macroglobulin and transferrin: a kinetic study using a monoclonal antibody against a lysosomal membrane glycoprotein (LAMP-1).

1988 • 20 citations

Rat plasma α₁‐inhibitor₃ binds to receptors for α₂‐macroglobulin

1987 • 20 citations

Synthesis and secretion of α₂‐macroglobulin by human hepatocytes in culture

1988 • 19 citations

Human hepatocytes exhibit receptors for α₂‐macroglobulin and pregnancy zone protein‐proteinase complexes

1988 • 19 citations

Isolation and renaturation of α2-macroglobulin receptor from diploid human fibroblasts

1983 • 18 citations

Assignment of the gene coding for the α2-macroglobulin receptor to mouse chromosome 15 and to human chromosome 12q13–q14 by isotopic and nonisotopic in situ hybridization

1992 • 16 citations

α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites

1983 • 16 citations

Membrane blebbing is associated with Ca²⁺‐activated hyperpolarizations induced by serum and α₂‐macroglobulin

1987 • 14 citations

Pregnancy zone protein: a re-evaluation of serum levels in healthy women and in women suffering from breast cancer or trophoblastic disease

1990 • 14 citations

Surface expression of the α2-macroglobulin receptor on human malignant blood cells

1992 • 14 citations

Murine T cell proliferation can be specifically augmented by macrophages fed with specific antigen: α-2-macroglobulin conjugate

1987 • 14 citations

Three different conformational states of pregnancy zone protein identified by monoclonal antibodies.

1988 • 12 citations

Uptake of rat and human α₂‐macroglobulin‐trypsin complexes into rat and human cells

1985 • 12 citations

Low alpha 2-macroglobulin-proteinase complex binding: a common but not exclusive characteristic of malignant cells.

1989 • 11 citations

Biochemical investigation of the pathogenesis of Heymann Nephritis

1986 • 11 citations

Characterization of carbohydrates in the α2-macroglobulin receptor

1992 • 11 citations

Cell association and degradation of pregnancy zone protein-chymotrypsin complex in cultured human monocytes

1988 • 9 citations

Release of lipoprotein lipase and hepatic lipase activities. Effects of heparin and a low molecular weight heparin fragment

1990 • 9 citations

A Receptor-Mediated Antigen Delivery and Incorporation System: Administration of α2-Macroglobulin-Cytochrome c Conjugate Induced High Concentrations of Antibodies Against Cytochrome c in Mice

1993 • 8 citations

Pregnancy zone protein: a re-evaluation of serum levels in healthy women and in women suffering from breast cancer or trophoblastic disease

1990 • 7 citations

The LDL receptor

1990 • 7 citations

Receptor-mediated endocytosis of α2macroglobulin by a glioma cell line

1993 • 6 citations

In vivo inflammatory stimulation induces a transient change in the binding of thrombin to rat peritoneal macrophages

1992 • 5 citations

Uptake of alpha 2‐macroglobulin–trypsin complex by human placenta is mediated by a microvillous membrane receptor

1989 • 4 citations

Release of lipoprotein lipase and hepatic lipase activities. Effects of heparin and a low molecular weight heparin fragment

1990 • 4 citations

Pregnancy zone protein, a proteinase binding α-macroglobulin. Stopped-flow kinetic studies of its interaction with chymotrypsin

1991 • 4 citations