A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Principles of Bone Biology

2019 • 1,699 citations

Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.

1983 • 1,535 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Principles of Bone Biology

1997 • 1,367 citations

The ovariectomized rat model of postmenopausal bone loss

1991 • 1,345 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

A microtomographic system for the nondestructive evaluation of bone architecture

1996 • 885 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

1992 • 557 citations

Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture

1992 • 535 citations

Advances in Bone Biology: The Osteoclast*

1996 • 522 citations

A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues

1981 • 520 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1997 • 401 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

1993 • 331 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

1994 • 317 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption

1996 • 285 citations

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.

1995 • 270 citations

Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc−/− mutant mice

1997 • 270 citations

Cellular and Molecular Biology of Bone

1993 • 249 citations

Focal Adhesion Kinase Tyrosine-861 Is a Major Site of Phosphorylation by Src

1996 • 224 citations

Osteoclasts express high levels of pp60c-src in association with intracellular membranes.

1992 • 221 citations

Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone

1984 • 219 citations

Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice.

1988 • 218 citations

Vertebrate non‐receptor protein–tyrosine kinase families

1996 • 154 citations

Augmented Mitogenic Responsiveness to Epidermal Growth Factor in Murine Fibroblasts That Overexpress pp60^c-src

1988 • 147 citations

Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity.

1995 • 130 citations

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

1996 • 119 citations

Inhibitors of tyrosine kinase

1997 • 107 citations

Bone remodeling and its disorders

1999 • 97 citations

Substrate Recognition by Osteoclast Precursors Induces C-src/Microtubule Association

1997 • 97 citations

Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo.

1993 • 91 citations

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.

1997 • 89 citations

Osteoclasts express high levels of p60^c‐src, preferentially on ruffled border membranes

1992 • 87 citations

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

1988 • 87 citations

Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate.

1992 • 68 citations

CELLULAR AND MOLECULAR BIOLOGY OF THE OSTEOCLAST

1993 • 65 citations

Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts

1997 • 60 citations

Bone remodeling and its disorders

1996 • 50 citations

Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage

1995 • 47 citations

Colony Stimulating Factor-1–Induced Osteoclast Spreading Depends on Substrate and Requires the Vitronectin Receptor and the c-src Proto-Oncogene

1998 • 45 citations

Possible involvement of focal adhesion kinase, p125^FAK, in osteoclastic bone resorption

1995 • 45 citations

N-terminal truncation of salmon calcitonin leads to calcitonin antagonists

1992 • 41 citations

Fluoroaluminate Induces Pertussis Toxin-Sensitive Protein Phosphorylation: Differences in MC3T3-E1 Osteoblastic and NIH3T3 Fibroblastic Cells

1997 • 34 citations

Purification and biochemical characterization of non-myristoylated recombinant pp60c-src kinase

1992 • 29 citations

Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor.

1997 • 25 citations

Pp60 c-src expression and activity in MG-63 osteoblastic cells modulated by PTH but Not required for PTH-mediated adenylate cyclase response

1994 • 17 citations

Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity

1995 • 16 citations

Quantitation of serum amyloid P component by an enzyme-linked immunoassay

1986 • 14 citations

ChemInform Abstract: Synthesis and Biological Activity of Pyrrolo(2,3‐d)pyrimidines.

1989 • 1 citations