Regulation of Cyclooxygenase-2 by Interferon γ and Transforming Growth Factor α in Normal Human Epidermal Keratinocytes and Squamous Carcinoma Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

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Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

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Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Stem cell patterning and fate in human epidermis

1995 • 788 citations

Keratinocytes as initiators of inflammation

1991 • 756 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

p38 Mitogen-activated Protein Kinase Regulates Cyclooxygenase-2 mRNA Stability and Transcription in Lipopolysaccharide-treated Human Monocytes

1999 • 495 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

The keratinocyte handbook

1995 • 428 citations

Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.

1996 • 426 citations

Identification of a major keratinocyte cell envelope protein, loricrin

1990 • 420 citations

Characterization of the human gene (PTGS2) encoding prostaglandin‐endoperoxide synthase 2

1994 • 396 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

Discovery of a second 15 S -lipoxygenase in humans

1997 • 388 citations

Oxidative Damage of Cardiomyocytes Is Limited by Extracellular Regulated Kinases 1/2-mediated Induction of Cyclooxygenase-2

1999 • 382 citations

The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation

1997 • 370 citations

Regulation of prostaglandin synthase-1 and prostaglandin synthase-2

1994 • 337 citations

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

1997 • 317 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

1998 • 275 citations

Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

1994 • 259 citations

Involvement of nuclear factor kB in the regulation of cyclooxygenase‐2 expression by interleukin‐1 in rheumatoid synoviocytes

1997 • 252 citations

The epidermis: rising to the surface

1994 • 245 citations

Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum

1996 • 244 citations

Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1982 • 237 citations

Dihydroxy Bile Acids Activate the Transcription of Cyclooxygenase-2

1998 • 210 citations

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

1994 • 207 citations

Ceramide Regulates the Transcription of Cyclooxygenase-2

1998 • 203 citations

Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer

1998 • 197 citations

Transcriptional Regulation of Cyclooxygenase-2 in Mouse Skin Carcinoma Cells

1998 • 197 citations

Interleukin-10 Production by Cultured Human Keratinocytes: Regulation by Ultraviolet B and Ultraviolet A1 Radiation

1995 • 196 citations

Psoriasis Induced at the Injection Site of Recombinant Interferon Gamma

1990 • 187 citations

Effect of interleukin‐1β, tumour necrosis factor‐α and interferon‐γ on the induction of cyclo‐oxygenase‐2 in cultured human airway smooth muscle cells

1997 • 173 citations

STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin

1996 • 165 citations

Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids.

1992 • 158 citations

Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1.

1994 • 151 citations

Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

1997 • 150 citations

Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

1995 • 149 citations

Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells.

1997 • 146 citations

Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation.

1994 • 145 citations

Cyclooxygenases in Human and Mouse Skin and Cultured Human Keratinocytes: Association of COX-2 Expression with Human Keratinocyte Differentiation

1996 • 134 citations

Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers

1996 • 132 citations

Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)

1989 • 121 citations

Regulation of type I (epidermal) transglutaminase mRNA levels during squamous differentiation: down regulation by retinoids.

1989 • 119 citations

Primary structure of keratinocyte transglutaminase.

1990 • 118 citations

Interferon‐γ and Nitric Oxide Down‐Regulate Lipopolysaccharide‐Induced Prostanoid Production in Cultured Rat Microglial Cells by Inhibiting Cyclooxygenase‐2 Expression

1996 • 115 citations

Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: Suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2

1998 • 112 citations

Decreased growth inhibition by recombinant gamma interferon is associated with increased transforming growth factor-α production in keratinocytes cultured from psoriatic lesions

1989 • 109 citations

Ligands and Activators of Nuclear Hormone Receptors Regulate Epidermal Differentiation During Fetal Rat Skin Development

1998 • 104 citations

Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes

1998 • 96 citations

Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

1991 • 94 citations

Cytokine Expression by Epidermal Cell Subpopulations

1992 • 93 citations

Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation

1994 • 89 citations

Correlation between expression of peroxisome proliferator-activated receptor β and squamous differentiation in epidermal and tracheobronchial epithelial cells

1999 • 86 citations

Regulation of Peroxisome Proliferator-Activated Receptors

1998 • 71 citations

Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1β-induced DNA binding activity ofcis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes

1998 • 67 citations

Gamma-interferon induces an irreversible growth arrest in mid-G1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma.

1996 • 62 citations

Interleukin 1a, Tumor Necrosis Factor a, and Interferon ? in Psoriasis

1991 • 62 citations

Selective changes in laminin adhesion and alpha 6 beta 4 integrin regulation are associated with the initial steps in keratinocyte maturation.

1996 • 59 citations

Alternate COX-2 Transcripts Are Differentially Regulated: Implications for Post-Transcriptional Control

1997 • 57 citations

Interferon γ-dependent Induction of Human Intercellular Adhesion Molecule-1 Gene Expression Involves Activation of a Distinct STAT Protein Complex

1997 • 54 citations

Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells.

1997 • 47 citations

Epidermal Differentiation and Squamous Metaplasia: From Stem Cell to Cell Death

1997 • 45 citations

Endogenous prostaglandin E2 modulates calcium-induced differentiation in human skin keratinocytes

1993 • 43 citations

Regulation of epidermal transglutaminase activity and terminal differentiation by retinoids and phorbol esters.

1983 • 42 citations

Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes

1996 • 35 citations

Eicosanoids, fatty acids and neutrophils: Their relevance to the pathophysiology of disease

1995 • 34 citations

Interferon-γ-mediated Inactivation of Transcription of the 230-kDa Bullous Pemphigoid Antigen Gene (BPAG1) Provides Novel Insight into Keratinocyte Differentiation

1995 • 33 citations

Regulation of prostaglandin H2 synthase-2 expression in primary human amnion cells by tyrosine kinase dependent mechanisms

1998 • 31 citations

Prostaglandin Synthase 2 Expression in Epidermal Growth Factor-Dependent Proliferation of Mouse Keratinocytes

1996 • 24 citations

Tumor‐Necrosis Factor‐α Modulates Mitogen‐Activated Protein Kinase Activity of Epidermal‐Growth‐Factor‐Stimulated MCF‐7 Breast Cancer Cells

1997 • 18 citations