DNA Immunotherapeutics: New Potential Treatment Modalities for Allergic Disease

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

DNA VACCINES

1997 • 977 citations

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

1997 • 919 citations

DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.

1996 • 764 citations

Long-term persistence of plasmid DNA and foreign gone expression in mouse muscle

1992 • 743 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.

1990 • 603 citations

Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization.

1997 • 566 citations

Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.

1994 • 550 citations

Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization.

1996 • 524 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

Vaccination against tuberculosis by DNA injection

1996 • 513 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

Antitumor Activity of Deoxyribonucleic Acid Fraction From <italic>Mycobacterium bovis</italic> BCG. I. Isolation, Physicochemical Characterization, and Antitumor Activity<xref ref-type="fn" rid="FN2">2</xref>

1984 • 471 citations

Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA

1993 • 432 citations

DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody

1993 • 401 citations

Survey of fatalities from skin testing and immunotherapy 1985–1989

1993 • 380 citations

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.

1991 • 378 citations

DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth

1992 • 370 citations

Gene vaccination: plasmid DNA is more than just a blueprint

1998 • 359 citations

Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA

1993 • 344 citations

Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus

1995 • 325 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

Immunoprophylaxis of allergen–induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization

1996 • 293 citations

Activation of human B cells by phosphorothioate oligodeoxynucleotides.

1996 • 292 citations

A Double-Blind Study of the Effectiveness and Specificity of Injection Therapy in Ragweed Hay Fever

1965 • 277 citations

Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.

1967 • 269 citations

Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids.

1997 • 257 citations

Suppressive vaccination with DNA encoding a variable region gene of the T–cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity

1996 • 244 citations

DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines.

1996 • 221 citations

Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.

1978 • 194 citations

Synthetic Oligonucleotides with Particular Base Sequences from the cDNA Encoding Proteins of Mycobacterium bovis BCG Induce Interferons and Activate Natural Killer Cells

1992 • 183 citations

Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen

1994 • 176 citations

CpG DNA: A pathogenic factor in systemic lupus erythematosus?

1995 • 162 citations

DNA Vaccines

1996 • 143 citations

Inducers of interferon and host resistance. 3. Double-stranded RNA from reovirus type 3 virions (reo 3-RNA).

1967 • 142 citations

Immunization with DNA

1994 • 132 citations

Oligonucleotide Sequences Required for Natural Killer Cell Activation

1992 • 131 citations

Binding of Oligoguanylate to Scavenger Receptors Is Required for Oligonucleotides to Augment NK Cell Activity and Induce IFN

1994 • 128 citations

Use of DNA Encoding Influenza Hemagglutinin as an Avian Influenza Vaccine

1993 • 125 citations

Nonfatal systemic allergic reactions induced by skin testing and immunotherapy.

1993 • 124 citations

Synthetic Oligonucleotides with Certain Palindromes Stimulate Interferon Production of Human Peripheral Blood Lymphocytes in vitro

1994 • 89 citations

Immunotherapy With Allergens

1992 • 83 citations

Liquid-hexatic phase transitions in single molecular layers of liquid-crystal films

1992 • 71 citations

In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG.

1986 • 70 citations

The Influence of DNA Structure on the in Vitro Stimulation of Murine Lymphocytes by Natural and Synthetic Polynucleotide Antigens

1993 • 68 citations

Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle.

1994 • 65 citations

Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo

1994 • 60 citations

Inhibition of specific IgE response in vivo by allergen-gene transfer

1996 • 57 citations

Induction of antibodies to a kappa V region by gene immunization.

1993 • 56 citations

Hexamer Palindromic Oligonucleotides with 5′CG-3′ Motif(s) Induce Production of Interferon

1996 • 54 citations

Inhibition of IgE Antibody Formation by Plasmid DNA Immunization Is Mediated by both CD4+ and CD8+ T Cells

1997 • 50 citations

Interferon β, a cofactor in the interferon γ production induced by gram-negative bacteria in mice.

1995 • 46 citations

Antitumor Activity of Synthetic Oligonucleotides with Sequences from cDNA Encoding Proteins of Mycobacterium bovis BCG

1992 • 45 citations

Nucleic Acid Malaria Vaccines

1995 • 33 citations

Interleukin 12: A Proinflammatory Cytokine with Immunoregulatory Functions That Bridge Innate Resistance and Antisen-Specific Adaptive Immunity

1995 • 30 citations

Immunotherapy With Allergens

1997 • 27 citations

Gene immunization for allergic disorders

1997 • 15 citations

A DNA vaccine for allergen immunotherapy using the latex allergen Hev b 5.

1997 • 13 citations

Immunotherapy with allergens

1997 • 11 citations