Upregulation of Angiotensin II Type 1 Receptor, Inflammatory Mediators, and Enzymes of Arachidonate Metabolism in Obese Zucker Rat Kidney

Angiotensin-Receptor Blockade versus Converting–Enzyme Inhibition in Type 2 Diabetes and Nephropathy

2004 • 901 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury

2003 • 518 citations

Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats

1988 • 413 citations

Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes

2000 • 372 citations

Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells

2003 • 340 citations

Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells.

1992 • 332 citations

Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy

2000 • 266 citations

The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice

1996 • 265 citations

The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury.

1992 • 263 citations

Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients

2003 • 254 citations

Angiotensin receptors: distribution, signalling and function

2001 • 242 citations

Insulin Induces Upregulation of Vascular AT ₁ Receptor Gene Expression by Posttranscriptional Mechanisms

1998 • 221 citations

The AT ₁ -Type Angiotensin Receptor in Oxidative Stress and Atherogenesis

2002 • 201 citations

Effects of genetic obesity on renal structure and function in the Zucker rat.

1985 • 199 citations

Angiotensin II Type 1 Receptor Overexpression in Podocytes Induces Glomerulosclerosis in Transgenic Rats

2004 • 195 citations

Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy

2004 • 191 citations

Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension1

2002 • 187 citations

Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy

2003 • 187 citations

Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes

2001 • 185 citations

ACE Inhibitors Improve Diabetic Nephropathy Through Suppression of Renal MCP-1

2003 • 179 citations

Renal Disease in Patients With Massive Obesity

1986 • 179 citations

Angiotensin II Receptors and Functional Correlates

1992 • 178 citations

HEREDITARY OBESITY IN THE RAT ASSOCIATED WITH HYPERLIPEMIA*

1965 • 176 citations

Antihypertensive effects of CS-045 treatment in obese Zucker rats

1993 • 153 citations

Effects of Body-Weight Loss and Captopril Treatment on Proteinuria Associated with Obesity

1995 • 148 citations

The Oxidized Lipid and Lipoxygenase Product 12(S)-Hydroxyeicosatetraenoic Acid Induces Hypertrophy and Fibronectin Transcription in Vascular Smooth Muscle Cells via p38 MAPK and cAMP Response Element-binding Protein Activation

2002 • 132 citations

Abnormal oral glucose tolerance in genetically obese (fa/fa) rats

1985 • 124 citations

Insulin and angiotensin II are additive in stimulating TGF-β1 and matrix mRNAs in mesangial cells

1996 • 116 citations

Effects of genetic obesity on renal structure and function in the Zucker rat. II. Micropuncture studies.

1985 • 114 citations

p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli

2001 • 103 citations

12-Lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy

2001 • 102 citations

Renal expression of COX-2, ANG II, and AT₁receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory

2004 • 94 citations

Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat

2001 • 94 citations

High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy

2004 • 93 citations

Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model

2003 • 93 citations

Interaction of MAPK and 12-lipoxygenase pathways in growth and matrix protein expression in mesangial cells

2002 • 84 citations

A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease.

1996 • 82 citations

Renal injury in obese Zucker rats: glomerular hemodynamic alterations and effects of enalapril

1992 • 71 citations

Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis

1994 • 69 citations

Cyclooxygenase-2 selective inhibitors and the kidney

2001 • 50 citations

Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice11See Editorial by Kasinath, p. 1918.

2003 • 46 citations

Renal Cyclooxygenase-2 (Cox-2)

2004 • 45 citations

Increased Urinary Excretion of Monocyte Chemoattractant Protein-1 in Proteinuric Renal Diseases

2003 • 37 citations

Renoprotection by angiotensin-receptor blockers and ACE inhibitors in hypertension

2001 • 37 citations

Brief periods of hyperphagia cause renal injury in the obese Zucker rat

1999 • 32 citations

Effect of enalapril and losartan on the events that precede diabetic nephropathy in rats

2002 • 27 citations

Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels

2002 • 24 citations