12-Lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Protein kinase C, calcium and phospholipid degradation

1992 • 400 citations

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

1992 • 353 citations

mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

1993 • 300 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium

1991 • 243 citations

Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells.

1994 • 230 citations

High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule

1990 • 196 citations

Selective activation of the γ‐subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

1989 • 188 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.

1993 • 161 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes.

1990 • 145 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells

1992 • 135 citations

Molecular cloning of a 12‐lipoxygenase cDNA from rat brain

1993 • 115 citations

Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy.

1994 • 106 citations

Lipoxygenase activity in rat kidney glomeruli, glomerular epithelial cells, and cortical tubules.

1982 • 106 citations

Superoxide generation by lipoxygenase in the presence of NADH and NADPH

1994 • 102 citations

A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease.

1996 • 82 citations

Mechanisms of ANG II-induced mitogenic responses: role of 12-lipoxygenase and biphasic MAP kinase

1996 • 82 citations

Exposure of human renal proximal tubular cells to glucose leads to accumulation of type IV collagen and fibronectin by decreased degradation

1997 • 79 citations

Arachidonic acid release by bombesin. A novel postreceptor target for heterologous mitogenic desensitization.

1990 • 76 citations

Early increased renal procollagen α1(IV) mRNA levels in streptozotocin induced diabetes

1992 • 69 citations

Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis

1994 • 69 citations

Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity.

1990 • 66 citations

Potential Role of TGF-β in Diabetic Nephropathy

1998 • 65 citations

Platelet-derived growth factor BB mediated regulation of 12-lipoxygenase in porcine aortic smooth muscle cells

1996 • 63 citations

Gene expression of metalloproteinase and its inhibitor in mesangial cells exposed to high glucose

1992 • 54 citations

Evidence That Angiotensin II and Lipoxygenase Products Activate c-Jun NH ₂ -Terminal Kinase

1997 • 51 citations

Arachidonate 12-lipoxygenase of rat pineal glands: Catalytic properties and primary structure deduced from its cDNA

1994 • 50 citations

Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose

1998 • 47 citations

Mesangial cell immune injury. Synthesis, origin, and role of eicosanoids.

1991 • 47 citations

Role of specific isoforms of protein kinase C in angiotensin II and lipoxygenase action in rat adrenal glomerulosa cells

1994 • 43 citations

Platelet-derived growth factor (PDGF)-induced phospholipase C-mediated hydrolysis of phosphoinositides in vascular smooth muscle cells — different sensitivity of PDGF- and angiotensin II-induced phospholipase C reactions to protein kinase C-activating phorbol esters

1988 • 34 citations

Molecular analysis of glomerular diseases in renal biopsies: initial results of a collaborative international study. The International Study Group for Molecular Study of Kidney Biopsies.

1996 • 23 citations

Mesangial cell immune injury. Hemodynamic role of leukocyte- and platelet-derived eicosanoids.

1992 • 21 citations

Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells

1999 • 20 citations

An Evaluation of 1a-Hydroxy-and 1,25-Dihydroxyvitamin D3 in the Treatment of Renal Bone Disease

2015 • 11 citations

Modulatory effect of arachidonate 5-lipoxygenation on glomerular cell proliferation in nephrotoxic serum nephritis.

1993 • 10 citations

Involvement of Synthesis and Degradation Pathways of Collagen Type IV in Human Glomerulosclerosis: Molecular Analysis by in situ Reverse Transcription and Competitive Polymerase Chain Reaction

2015 • 8 citations

Lipoxygenase Products and Their Functions in Glomeruli

1989 • 8 citations

Dimethyl sulfoxide enhances hexose monophosphate shunt activity in cultured glomerular mesangial cells, leukocytes and erythrocytes.

1991 • 7 citations

Pathophysiologic role of eicosanoids in mesangial cell immune injury.

1993 • 6 citations