Renal expression of COX-2, ANG II, and AT₁receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease

2001 • 1,050 citations

Nephron adaptation to renal injury or ablation

1985 • 633 citations

Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide.

1995 • 477 citations

Proinflammatory actions of angiotensins

2001 • 409 citations

Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model

1992 • 404 citations

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats

1998 • 402 citations

Functional adaptation to reduction in renal mass

1979 • 308 citations

Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

1999 • 305 citations

Novel nonsterodial anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat

1994 • 293 citations

Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis.

1998 • 285 citations

Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats

2002 • 256 citations

Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.

1997 • 255 citations

Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody

1997 • 254 citations

Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II

2002 • 248 citations

Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics.

1983 • 234 citations

Angiotensin II Participates in Mononuclear Cell Recruitment in Experimental Immune Complex Nephritis Through Nuclear Factor-κB Activation and Monocyte Chemoattractant Protein-1 Synthesis

1998 • 226 citations

Upregulation of renin-angiotensin system during differentiation of monocytes to macrophages

1999 • 222 citations

Transforming growth factor β1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system

1997 • 206 citations

Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II

2002 • 201 citations

Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney.

1995 • 198 citations

Receptor-Mediated Intrarenal Angiotensin II Augmentation in Angiotensin II–Infused Rats

1996 • 193 citations

Induction of Cyclooxygenase-2 on Activated T Lymphocytes: Regulation of T Cell Activation by Cyclooxygenase-2 Inhibitors

1999 • 189 citations

Angiotensin II Activates Collagen I Gene Through a Mechanism Involving the MAP/ER Kinase Pathway

2000 • 175 citations

Intrarenal angiotensin II: Interstitial and cellular levels and site of production

2001 • 172 citations

A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats

2000 • 155 citations

Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitor on glomerular lesions

1991 • 150 citations

Combining an Antiproteinuric Approach with Mycophenolate Mofetil Fully Suppresses Progressive Nephropathy of Experimental Animals

1999 • 140 citations

Pharmacology of diclofenac sodium

1986 • 135 citations

Pathological Expression of Renin and Angiotensin II in the Renal Tubule after Subtotal Nephrectomy

1999 • 135 citations

Angiotensin Type 2 Receptor Antagonism Confers Renal Protection in a Rat Model of Progressive Renal Injury

2002 • 121 citations

Combined Mycophenolate Mofetil and Losartan Therapy Arrests Established Injury in the Remnant Kidney

2000 • 114 citations

Selective increase of cyclooxygenase-2 expression in a model of renal ablation

1998 • 113 citations

Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase

1994 • 112 citations

The inflammatory component in progressive renal disease—are interventions possible?

2002 • 105 citations

Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells

1998 • 103 citations

A better understanding of anti-inflammatory drugs based on isoforms of cyclooxygenase (COX-1 and COX-2).

1995 • 102 citations

Tumor Necrosis Factor-α Promotes Sustained Cyclooxygenase-2 Expression: Attenuation by Dexamethasone and NSAIDs

1997 • 101 citations

Upregulation of renal and systemic cyclooxygenase-2 in patients with active lupus nephritis.

1998 • 95 citations

Cyclooxygenase-2 Is Required for Tumor Necrosis Factor-α– and Angiotensin II–Mediated Proliferation of Vascular Smooth Muscle Cells

2000 • 84 citations

Angiotensin II Is Mitogenic for Cultured Rat Glomerular Endothelial Cells

1996 • 83 citations

Up-Regulation of Cyclooxygenase-2 by Product-Prostaglandin E2

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Renin Expression at Sites of Repair in the Infarcted Rat Heart

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Eicosanoids in experimental and human renal disease

1986 • 73 citations

Complement C5b-9-Mediated Arachidonic Acid Metabolism in Glomerular Epithelial Cells

2000 • 71 citations

Autoregulation of Human Monocyte-Derived Dendritic Cell Maturation and IL-12 Production by Cyclooxygenase- 2-Mediated Prostanoid Production

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Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney

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Angiotensin II control of the renal microcirculation in rats with reduced renal mass

1990 • 62 citations

Macrophage and myofibroblast proliferation in remnant kidney: role of angiotensin II.

1997 • 56 citations

Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons

1987 • 56 citations

Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney

1998 • 52 citations

Thromboxane stimulates synthesis of extracellular matrix proteins in vitro

1991 • 50 citations

Upregulation of juxtaglomerular NOS1 and COX-2 precedes glomerulosclerosis in fawn-hooded hypertensive rats

2001 • 39 citations

Ketorolac-Induced Acute Renal Failure and Hyperkalemia: Report of Three Cases

1994 • 36 citations

Fatal hyperkalemia related to combined therapy with a COX-2 inhibitor, ACE inhibitor and potassium rich diet

2002 • 35 citations

Subtotal Nephrectomy Stimulates Cyclooxygenase 2 Expression and Prostacyclin Synthesis in the Rat Remnant Kidney

2002 • 29 citations

Coinhibition of immune and renin-angiotensin systems reduces the pace of glomerulosclerosis in the rat remnant kidney.

1999 • 22 citations

Mesangial cell immune injury. Hemodynamic role of leukocyte- and platelet-derived eicosanoids.

1992 • 21 citations