Angiotensin receptors: distribution, signalling and function

Angiotensin II receptors and angiotensin II receptor antagonists.

1993 • 1,843 citations

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

1991 • 1,247 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

1991 • 808 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Functions of Angiotensin in the Central Nervous System

1987 • 726 citations

Angiotensin II type 2 receptor mediates programmed cell death.

1996 • 707 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Male–female differences in fertility and blood pressure in ACE-deficient mice

1995 • 644 citations

Genetic control of blood pressure and the angiotensinogen locus.

1995 • 627 citations

Circulating and tissue angiotensin systems.

1987 • 616 citations

Regulation of blood pressure by the type 1A angiotensin II receptor gene.

1995 • 599 citations

Counterregulatory Actions of Angiotensin-(1-7)

1997 • 507 citations

Cardiac Actions of Angiotensin II: Role of an Intracardiac Renin-Angiotensin System

1992 • 505 citations

The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.

1997 • 481 citations

Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction.

1995 • 441 citations

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

1996 • 438 citations

Expression of Angiotensin Type-1 (AT1) and Type-2 (AT2) Receptor mRNAs in the Adult Rat Brain: A Functional Neuroanatomical Review

1997 • 408 citations

Identification of two subtypes in the rat type I angiotensin II receptor

1992 • 401 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling

2000 • 385 citations

Angiotensinogen-deficient mice with hypotension.

1994 • 378 citations

Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia

1995 • 368 citations

Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

1998 • 338 citations

Levels of angiotensin and molecular biology of the tissue renin angiotensin systems

1993 • 333 citations

Expression of the Subtype 2 Angiotensin (AT ₂ ) Receptor Protein in Rat Kidney

1997 • 322 citations

Reduced growth, abnormal kidney structure, and type 2 (AT ₂ ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT _1A and AT _1B receptors for angiotensin II

1998 • 316 citations

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT ₂ ) angiotensin receptor

1999 • 316 citations

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

1996 • 311 citations

Mapping of angiotensin II receptor subtype heterogeneity in rat brain

1992 • 308 citations

Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis

1997 • 301 citations

Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome

1992 • 299 citations

Rat angiotensin II (type 1A) receptor mRNA regulation and subtype expression in myocardial growth and hypertrophy.

1993 • 286 citations

Pressure Overload Induces Cardiac Hypertrophy in Angiotensin II Type 1A Receptor Knockout Mice

1998 • 259 citations

Angiotensin Receptors and Their Therapeutic Implications

1996 • 256 citations

The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase

1992 • 252 citations

Angiotensin Type 2 Receptors Are Reexpressed by Cardiac Fibroblasts From Failing Myopathic Hamster Hearts and Inhibit Cell Growth and Fibrillar Collagen Metabolism

1997 • 250 citations

Angiotensin II Type 2 Receptor Is Upregulated in Human Heart With Interstitial Fibrosis, and Cardiac Fibroblasts Are the Major Cell Type for Its Expression

1998 • 241 citations

Important roles for angiotensin III and IV in the brain renin-angiotensin system

1997 • 241 citations

Characterization of angiotensin II receptor subtypes in rat heart.

1992 • 236 citations

The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells

1996 • 229 citations

Dephosphorylation of Sp1 by Protein Phosphatase 1 Is Involved in the Glucose-mediated Activation of the Acetyl-CoA Carboxylase Gene

1996 • 228 citations

Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase

1997 • 225 citations

Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.

1992 • 221 citations

Proposed Update of Angiotensin Receptor Nomenclature

1995 • 220 citations

Mitogen-activated Protein Kinases in Rat Brain Neuronal Cultures Are Activated by Angiotensin II Type 1 Receptors and Inhibited by Angiotensin II Type 2 Receptors

1996 • 191 citations

Angiotensin II Induction of Neurite Outgrowth by AT2 Receptors in NG108-15 Cells

1996 • 185 citations

Angiotensin II and alpha-adrenergic agonists inhibit rat liver adenylate cyclase.

1981 • 183 citations

Targeting deletion of angiotensin type 1B receptor gene in the mouse

1997 • 178 citations

Angiotensin II Receptors and Functional Correlates

1992 • 178 citations

Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.

1985 • 175 citations

Differential distribution of angiotensin AT2 receptors in the normal and failing human heart.

1998 • 159 citations

Cell biology and genetics of angiotensin in cardiovascular disease

1994 • 154 citations

Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein

1994 • 147 citations

Interaction Between the Renin-Angiotensin-Aldosterone and Sympathetic Nervous Systems

1992 • 141 citations

Inotropic effects of angiotensin II on human cardiac muscle in vitro.

1990 • 141 citations

Discrimination of angiotensin II receptor subtypes by dithiothreitol

1989 • 135 citations

Bovine Aortic Endothelial Cells Contain an Angiotensin-(1–7) Receptor

1997 • 135 citations

Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: An in vitro gene transfer study

1998 • 132 citations

Cloning of cDNA and Analysis of the Gene for Mouse Angiotensin II Type 2 Receptor

1993 • 127 citations

The Renin-Angiotensin System and Vascular Hypertrophy

1996 • 124 citations

Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor

1999 • 118 citations

Human Type 2 Angiotensin II Receptor Gene: Cloned, Mapped to the X Chromosome, and Its mRNA Is Expressed in the Human Lung

1994 • 110 citations

Stimulation of Different Subtypes of Angiotensin II Receptors, AT ₁ and AT ₂ Receptors, Regulates STAT Activation by Negative Crosstalk

1999 • 108 citations

Immunolocalization of Subtype 2 Angiotensin II (AT ₂ ) Receptor Protein in Rat Heart

1998 • 106 citations

Angiotensin II Receptor Antagonists: An Emerging New Class of Cardiovascular Therapeutics.

1999 • 103 citations

Angiotensin II receptor subtypes in the human central nervous system

1995 • 100 citations

Identification and characterization of a new binding site for angiotensin II in mouse neuroblastoma neuro-2A cells

1992 • 100 citations

Regulation of cell proliferation and growth by angiotensin II

1994 • 100 citations

Angiotensin II type 2 receptor-modulated changes in potassium currents in cultured neurons

1993 • 98 citations

Interaction of angiotensin with noradrenergic neuroeffector transmission

1987 • 90 citations

Angiotensin II Type 2 Receptor-Mediated Apoptosis of Cultured Neurons from Newborn Rat Brain**This work was supported by a grant from the NIH (NS-19441) and a postdoctoral fellowship (to U.V.S.) from the American Heart Association, Florida Affiliate.

1999 • 89 citations

AngiotensinII and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor

1998 • 87 citations

High resolution localization of angiotensin II receptors in rat renal medulla

1992 • 83 citations

Angiotensin as Neuromodulator/Neurotransmitter in Central Control of Body Fluid and Electrolyte Homeostasis

1995 • 82 citations

Changes in skin angiotensin II receptors in rats during wound healing

1992 • 82 citations

Receptors and their classification: focus on angiotensin II and the AT2 receptor

1998 • 80 citations

A βγ Dimer Derived from G13 Transduces the Angiotensin AT1 Receptor Signal to Stimulation of Ca2+ Channels in Rat Portal Vein Myocytes

1997 • 80 citations

Franz Volhard Lecture. Renin-angiotensin system: a dual tissue and hormonal system for cardiovascular control.

1992 • 80 citations

ONTOGENY OF ANGIOTENSIN II RECEPTORS

1996 • 79 citations

Renal growth and development in mice lacking AT_1Areceptors for angiotensin II

1998 • 77 citations

The Genomic Organization of Human Angiotensin II Type 1 Receptor

1994 • 77 citations

Characterization of the binding properties and physiological action of divalinal-angiotensin IV, a putative AT4 receptor antagonist

1996 • 76 citations

Pressure-overload hypertrophy is unabated in mice devoid of AT_1Areceptors

1998 • 75 citations

Distribution of angiotensin II receptor subtypes in the rabbit brain

1993 • 74 citations

Multiple Growth Factors Modulate mRNA Expression of Angiotensin II Type-2 Receptor in R3T3 Cells

1995 • 72 citations

Analysis of Functional Domains of Angiotensin II Type 2 Receptor Involved in Apoptosis

1999 • 71 citations

The Growth-dependent Expression of Angiotensin II Type 2 Receptor Is Regulated by Transcription Factors Interferon Regulatory Factor-1 and −2

1995 • 65 citations

Importance of Tyrosine Phosphorylation in Angiotensin II Type 1 Receptor Signaling

1996 • 65 citations

Nitric Oxide, A new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells.

1998 • 62 citations

Identification and characterisation of angiotensin II receptor subtypes in human brain

1993 • 61 citations

The Sequence and Genomic Organization of the Human Type 2 Angiotensin II Receptor

1995 • 60 citations

Identification, Distribution, and Expression of Angiotensin II Receptors in the Normal Human Prostate and Benign Prostatic Hyperplasia¹

2001 • 60 citations

The distribution of angiotensin II type 1 receptors, and the tissue renin-angiotensin systems

1995 • 59 citations

Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.

1994 • 58 citations

Mechanisms of angiotensin H formation in humans

1995 • 55 citations

In vitro autoradiographic localization of binding to angiotensin receptors in the rat heart

1990 • 51 citations

Differential actions of angiotensin-(1-7) in the kidney

1998 • 49 citations

The subtype 2 angiotensin receptor regulates renal prostaglandin F2 alpha formation in conscious rats

1997 • 48 citations

Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor

1994 • 48 citations

Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor

2000 • 46 citations

The distribution of angiotensin II receptors

1995 • 42 citations

Amino-Acids of the Third Transmembrane Domain of the AT1A Angiotensin-II Receptor Are Involved in the Differential Recognition of Peptide and Nonpeptide Ligands

1995 • 42 citations

Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy.

1996 • 41 citations

Angiotensin II stimulates macula densa basolateral sodium/hydrogen exchange via type 1 angiotensin II receptors.

1999 • 40 citations

Cloning, Characterization, and Genetic Mapping of the Rat Type 2 Angiotensin II Receptor Gene

1995 • 39 citations

Chromosomal Localization of Angiotensin II Type 1 Receptor Isoforms in the Rat

1993 • 34 citations

Angiotensin-converting enzyme-independent pathways of angiotensin II formation in human tissues and cardiovascular diseases.

1996 • 28 citations

Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle

1998 • 28 citations

The angiotensin (AT1) receptor.

1993 • 28 citations

Expression of a novel non-angiotensin II [125I]CGP 42112 binding site in healing wounds of the rat brain

1994 • 27 citations

Proceedings of the Symposium ‘Angiotensin AT₁ Receptors: From Molecular Physiology to Therapeutics’: ANGIOTENSIN II AND THE ADRENAL

1996 • 26 citations

Unopposed stimulation of the angiotensin AT2 receptor in the kidney

1998 • 23 citations

Simultaneous determination of intracellular free calcium and aldosterone production in bovine adrenal zona glomerulosa

1988 • 23 citations

Functional Aspects of Angiotensin Type 2 Receptor

1996 • 20 citations

Regulation of the Hypothalmic-Pituitary-Adrenal Axis and Vasopressin Secretion

1996 • 19 citations

The Renin-Angiotensin System in the Control of Systemic Arterial Pressure

1985 • 19 citations

Pharmacology of angiotensin receptors and AT 1 receptor blockers

1998 • 18 citations

Localization of the mRNA for the Angiotensin II Receptor Subtype 2 (AT2) in Follicular Granulosa Cells of the Rat Ovary by Nonradioactive In Situ Hybridization

1998 • 16 citations

Angiotensin II receptor isoforms in the rat adrenal gland: studies with the selective subtype antagonists DuP 753 and CGP42112A

1993 • 16 citations

Effects of growth factors on cell proliferation and angiotensin II type 2 receptor number and mRNA in PC12W and R3T3 cells1This work was supported by an Institut National de la Santé et de la Recherche Médicale-Merck, Sharpe and Dohme grant.1

1998 • 14 citations

Spectrum of use for the angiotensin-receptor blocking drugs

1999 • 14 citations

Angiotensin II receptor subtypes in the kidney: Distribution and function

1995 • 12 citations

Angiotensin converting enzyme inhibitors in perspective: an update.

1993 • 3 citations