Potential clinical applications for high-dose nutritional antioxidants

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Can dietary beta-carotene materially reduce human cancer rates?

1981 • 1,575 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

1975 • 969 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Free radicals in cerebral ischemia.

1978 • 589 citations

ASSOCIATION BETWEEN CARDIOVASCULAR DEATH AND MYOCARDIAL INFARCTION AND SERUM SELENIUM IN A MATCHED-PAIR LONGITUDINAL STUDY

1982 • 576 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes

1977 • 497 citations

DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY

1981 • 489 citations

Dietary vitamin a and human lung cancer

1975 • 397 citations

[Selenium in biology and medicine].

1981 • 354 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

Selenium Distribution and Human Cancer Mortality

1971 • 266 citations

Relationship of Selenium to Cancer. I. Inhibitory Effect of Selenium on Carcinogenesis

1970 • 259 citations

Vitamin A and Lung Cancer<xref ref-type="fn" rid="FN2">2</xref>

1979 • 222 citations

Vitamin E. An inhibitor of the platelet release reaction.

1976 • 209 citations

Role of Selenium in The Chemoprevention of Cancer

1979 • 193 citations

Superoxide Dismutase, Glutathione Peroxidase, Catalase and Lipid Peroxidation of Normal and Sickled Erythrocytes

1980 • 193 citations

Selenium in Biology

1975 • 192 citations

Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice.

1980 • 189 citations

Factors Influencing the Inhibitory Effect of Selenium on Mice Inoculated with Ehrlich Ascites Tumor Cells

1980 • 177 citations

Selenium in human nutrition: Dietary intakes and effects of supplementation

1978 • 177 citations

Cardiac disease induced by chronic adriamycin administration in dogs and an evaluation of vitamin E and selenium as cardioprotectants.

1980 • 169 citations

Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors

1977 • 168 citations

Diet and azo dye tumors; effect of diet during a period when the dye is not fed.

1949 • 166 citations

The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers

1980 • 157 citations

Effects of selenium and of arsenic on the genesis of spontaneous mammary tumors in inbred C3H mice.

1974 • 149 citations

Effect of allopurinol on hemorrhagic shock

1969 • 140 citations

Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis.

1981 • 132 citations

Effects of selenium on azo dye hepatocarcinogenesis

1977 • 131 citations

Effect of Dietary Selenium on Glutathione Peroxidase in the Chick

1974 • 129 citations

Influence of vitamin E and selenium on immune response mechanisms.

1979 • 128 citations

β-Thromboglobulin - a Specific Marker of In-Vivo Platelet Release Reaction

1980 • 124 citations

Two years of clinical experience with biliopancreatic bypass for obesity

1980 • 123 citations

Antioxidants, lipid peroxidation and chemical-induced liver injury.

1973 • 122 citations

No chemical evidence of hepatic lipid peroxidation in acute ethanol toxicity

1968 • 121 citations

Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene

1979 • 117 citations

Effect of vitamin E supplementation on leukocyte function

1980 • 116 citations

The premature infant, vitamin E deficiency and retrolental fibroplasia1,2

1974 • 110 citations

Glutathione Peroxidase Activity as a Function of Dietary Selenomethionine

1974 • 109 citations

Immunologic Responses of Mice Fed Diets Supplemented with Selenite Selenium

1973 • 109 citations

Vitamin E and immune response. I. Enhancement of helper T cell activity by dietary supplementation of vitamin E in mice.

1979 • 108 citations

LIPID PEROXIDATION AND THE CYTOTOXICITY OF COPPER*

1980 • 107 citations

Selenium and cancer: A review

1976 • 107 citations

Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats

1975 • 106 citations

Modulation of platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E

1981 • 99 citations

The premature infant, vitamin E deficiency and retce:rolental fibroplasia

1974 • 97 citations

Quantitative evaluation of vitamin E in the treatment of angina pectoris

1977 • 91 citations

Vitamin A and lung cancer.

1980 • 90 citations

Orgotein: a new anti-inflammatory metalloprotein drug: preliminary evaluation of clinical efficacy and safety in degenerative joint disease.

1974 • 89 citations

Leukocyte ascorbic acid and its relationship to coronary artery disease in man

1980 • 89 citations

Selenium-mediated inhibition of mouse mammary tumorigenesis

1980 • 89 citations

Effect of ascorbic acid on rectal polyps of patients with familial polyposis.

1975 • 87 citations

Reduced Chronic Hemolysis during High-Dose Vitamin E Administration in Mediterranean-Type Glucose-6-Phosphate Dehydrogenase Deficiency

1980 • 85 citations

Protective effects of supplemental vitamin E against infection.

1979 • 85 citations

Lipid Peroxidation in Iron-Overloaded Spleens

1981 • 83 citations

Enhanced Immunoglobulin M and Immunoglobulin G Antibody Titers in Mice Fed Selenium

1973 • 82 citations

Protective effects of dietary α-tocopherol in rats exposed to toxic levels of ozone and nitrogen dioxide

1973 • 81 citations

Influence of dietary vitamin E on prostaglandin biosynthesis in rat blood

1975 • 81 citations

Effect of allopurinol in renal ischemia.

1972 • 81 citations

Superoxide dismutase activity of Cu²⁺ —amino acid chelates

1972 • 81 citations

Factors influencing the anticarcinogenic efficacy of selenium in dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats.

1981 • 79 citations

EFFECT OF SINGLET OXYGEN QUENCHERS ON OXIDATIVE DAMAGE TO LIPOSOMES INITIATED BY PHOTOSENSITIZATION OR BY RADIOFREQUENCY DISCHARGE

1974 • 77 citations

The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model

1977 • 77 citations

COULD SUPEROXIDE CAUSE CIRRHOSIS?

1982 • 77 citations

Tocopherol in Osteoarthritis: A Controlled Pilot Study

1978 • 75 citations

TREATMENT OF INTERMITTENT CLAUDICATION WITH VITAMIN E

1958 • 73 citations

Relationship of Dietary Selenium Concentration; Chemical Cancer Induction; and Tissue Concentration of Selenium in Rats

1973 • 73 citations

Cell penetration by exogenous superoxide dismutase.

1980 • 73 citations

Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs.

1982 • 73 citations

Effects of temporary selenium supplementation on the genesis of spontaneous mammary tumors in inbred female C₃H/St mice

1980 • 72 citations

Adriamycin cardiotoxicity: early detection by systolic time interval and possible prevention by coenzyme Q10.

1978 • 71 citations

Enhancement of interferon production by poly(rI)·poly(rC) in mouse cell cultures by ascorbic acid

1975 • 69 citations

Long-time treatment of intermittent claudication with vitamin E1

1974 • 66 citations

The effect of allopurinol on the degree of early myocardial ischemia

1980 • 64 citations

Long-time treatment of intermittent claudication with vitamin E

1974 • 63 citations

Effect of selenium-vitamin E on adriamycin-induced cardiomyopathy in rabbits.

1978 • 63 citations

Alpha tocopherol in the treatment of intermittent claudication.

1971 • 61 citations

Superoxide Dismutase Activity of Cu(Tyr)₂and Cu, Co-Erythrocuprein

1975 • 61 citations

A decrease in irreversibly sickled erythrocytes in sickle cell anemia patients given vitamin E

1980 • 61 citations

Some effects of ethanol and carbon tetrachloride on lipoperoxidation in rat liver

1969 • 56 citations

An increase in vitamin E requirement induced by high supplementation of vitamin C in rats

1981 • 56 citations

Enhanced Interferon Response to Murine Leukemia Virus by Ascorbic Acid

1974 • 55 citations

Affinity hypoxia as a pathogenetic factor of microangiopathy with particular reference to diabetic retinopathy.

1980 • 55 citations

The effect of variations in vitamin C intake on the cellular immune response of guinea pigs

1980 • 53 citations

Vitamin E in Kitten Oxygen-Induced Retinopathy

1979 • 53 citations

A double-blind trial of vitamin E in angina pectoris1,2

1974 • 53 citations

Effect of dietary selenium on the interaction between 2-acetylaminofluorene and rat liver DNA in vivo.

1980 • 51 citations

Effects of selenium and retinoic acid on the metabolism of N-acetylaminofluorene and N-hydroxyacetylamino-fluorene

1978 • 48 citations

Antiinflammatory Activity of Vitamin E

1972 • 46 citations

Effects of Dietary Selenium, Methionine, Fat Level and Tocopherol on Rat Growth

1964 • 45 citations

Anti-Inflammatory, Immunologic and Carcinostatic Attributes of Selenium in Experimental Animals

1981 • 45 citations

Effects of selenium on chemical carcinogens

1980 • 44 citations

THE EFFECT OF ASCORBIC ACID ON PRODUCTION OF HUMAN INTERFERON AND THE ANTIVIRAL ACTIVITY IN VITRO

1976 • 44 citations

Dietary selenium intake and growth of the MT-W9B transplantable rat mammary tumor

1981 • 43 citations

A double-blind trial of vitamin E in angina pectoris

1974 • 43 citations

REACTION OF NITRITE WITH VITAMINS C AND E

1980 • 42 citations

Effect of selenium and dimethyl dioctadecyl ammonium bromide on the vaccine-induced immunity of Swiss-Webster mice against malaria (Plasmodium berghei)

1980 • 41 citations

The use of water-soluble bioflavonoid-ascorbic acid complex in the treatment of recurrent herpes labialis

1978 • 40 citations

Selenium and myocardial infarction: Glutathione peroxidase in platelets

1981 • 40 citations

Decreased platelet vitamin C in diabetes mellitus: Possible role in hyperaggregation

1979 • 39 citations

Prostacyclin and atherosclerosis

1979 • 39 citations

Effect of graded dietary levels of selenium on tracheal carcinomas induced by 1-methyl-1-nitrosourea

1979 • 38 citations

Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy.

1975 • 36 citations

On the nature of cardio-active substances from ganglia

1969 • 36 citations

Is vitamin E involved in the autoimmune mechanism?

1978 • 36 citations

Lupus erythematosus and vitamin E: an effective and nontoxic therapy.

1979 • 35 citations

Nutritional Interrelationships among Vitamin E, Selenium, Antioxidants and Ethyl Alcohol in the Rat

1973 • 34 citations

Effect of Stimulation of the Host Defense System by Coenzyme Q ₁₀ on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice

1973 • 34 citations

Ascorbic acid, neutrophil function, and the immune response.

1978 • 33 citations

Effect of Ascorbic Acid, Sodium Salicylate, and Caffeine on the Serum Interferon Level in Response to Viral Infection

1975 • 32 citations

Selenium in Health and Disease

1983 • 32 citations

Antiinflammation studies

1963 • 32 citations

Inhibition of Carcinogen Formation in Skin irradiated with Ultraviolet Light

1973 • 31 citations

Vitamin E and Platelet Aggregation

1981 • 30 citations

Vitamin E and platelet function.

1979 • 30 citations

Cardiac Effects of Sodium Selenite

1975 • 28 citations

α‐Tocopherol and serum lipoproteins

1981 • 28 citations

VITAMIN C AND DEEP-VEIN THROMBOSIS

1973 • 27 citations

Effects of dietary antioxidants on actinic tumor induction.

1974 • 27 citations

Immunological senescence in mice and its reversal by coenzyme Q10

1978 • 25 citations

Diet and resistance to disease

1982 • 25 citations

Bioenergetics in clinical medicine. VIII. Adminstration of coenzyme Q10 to patients with essential hypertension.

1976 • 24 citations

β-CAROTENE AND THE PHOTODERMATOSES

1975 • 24 citations

Effect and structure-activity relationship of the coenzymes Q on the phagocytic rate of rats

1972 • 22 citations

The effect of vitamin E on platelet aggregation

1976 • 21 citations

Prolonged Plasma Clotting Time and Decreased Fibrinolysis after Long Term Treatment with α-Tocopherol

1974 • 20 citations

Prevention of rabies by vitamin C

1975 • 18 citations

Vitamin C prophylaxis for posttransfusion hepatitis: lack of effect in a controlled trial

1981 • 17 citations

Point of view — A role for “nutritional insurance” supplementation in preventive medicine

1981 • 16 citations

Use of Vitamin E in Chronic Cystic Mastitis

1965 • 15 citations

Role of Selenium in Relation to Ubiquinone in the Rat

1961 • 15 citations

Role of membrane vitamin E and cytoplasmic glutathione in the regulation of phagocytic functions of neutrophils and monocytes.

1979 • 14 citations

New Horizons for Vitamin C

1977 • 14 citations

Relationships between coenzyme Q and vitamin E1

1974 • 13 citations

Vitamin E relieves most cystic breast disease; may alter lipids, hormones

1980 • 12 citations

Treatment of intermittent claudication with alpha-tocopherol

1980 • 9 citations

Effect of Vitamin E on Platelet Aggregation in Diabetic Retinopathy

1979 • 9 citations

The effect of tocopherol and of fat on the resistance of rats to anoxic anoxia.

1945 • 9 citations

Relationships between coenzyme Q and vitamin E

1974 • 9 citations

Prostacyclin and atherosclerosis.

1980 • 8 citations

In vivo and ex vivo Studies of the Effect of Vitamin E Pre‐Treatment on PGI₂ and TXA₂ Synthesis

1980 • 8 citations

VITAMIN E, SELENIUM, AND KNEE PROBLEMS

1975 • 6 citations

Optimized mitochondrial function as a nutritional strategy in cancer immunotherapy

1981 • 2 citations