Human Neutrophil Elastase Does not Bind to Alpha₁-Protease Inhibitor that Has Been Exposed to Activated Human Neutrophils

[1] Measurement of molecular weights by electrophoresis on SDS-acrylamide gel

1972 • 1,733 citations

Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.

1980 • 767 citations

Human leukocyte granule elastase: rapid isolation and characterization

1976 • 550 citations

Animal Models of Emphysema^1–3

1986 • 439 citations

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

1979 • 398 citations

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.

1978 • 364 citations

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

1982 • 352 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Enzymatic inactivation of human alpha-1-proteinase inhibitor by neutrophil myeloperoxidase

1979 • 270 citations

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

1978 • 264 citations

Potential Mediator of Inflammation

1980 • 255 citations

Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.

1981 • 222 citations

Lung injury induced by leukocytic proteases.

1979 • 183 citations

Elastase Release from Human Alveolar Macrophages: Comparison Between Smokers and Nonsmokers

1977 • 172 citations

Alpha1-antitrypsin and its deficiency.

1974 • 156 citations

Role of the Myeloperoxidase-H2O2-Halide System in Concanavalin A-Induced Tumor Cell Killing by Human Neutrophils

1979 • 142 citations

Interaction of human .alpha.-1-proteinase inhibitor with neutrophil myeloperoxidase

1981 • 119 citations

Alpha₁-Antitrypsin Deficiency

1978 • 116 citations

Limited proteolysis by macrophage elastase inactivates human alpha 1-proteinase inhibitor.

1980 • 107 citations

Possible mechanisms of emphysema in cigarette smokers. Release of elastase from human polymorphonuclear leukocytes by cigarette smoke condensate in vitro.

1978 • 100 citations

The Molecular Weight of Myeloperoxidase.

1958 • 93 citations

Microbicidal mechanisms of human granulocytes: synergistic effects of granulocyte elastase and myeloperoxidase or chymotrypsin-like cationic protein

1976 • 91 citations

Hemolysis and iodination of erythrocyte components by a myeloperoxidase- mediated system

1975 • 81 citations

EVALUATION OF THE PROTEASE-ANTIPROTEASE THEORY OF HUMAN DESTRUCTIVE LUNG DISEASE

1981 • 67 citations

Immunoreactive Granulocyte Elastase in Human Serum

1978 • 65 citations

The effects in vivo and in vitro of oxidative damage to purified alpha1-antitrypsin and to the enzyme-inhibiting activity of plasma.

1979 • 57 citations

Proteases and Protease Inhibitors in Chronic Obstructive Lung Disease

1978 • 52 citations

The use of tritiated elastin for the determination of subnanogram amounts of elastase

1977 • 33 citations

Emphysema associated with intravascular leukocyte sequestration. Comparison with papain-induced emphysema.

1981 • 30 citations

Proteolytic Lung Damage

1980 • 18 citations

Smoking and Disease

1975 • 14 citations

Protease and antiprotease responses in lung and peripheral blood in experimental canine pneumococcal pneumonia.

1980 • 9 citations

ELECTRON AND LIGHT MICROSCOPIC STUDIES OF THE LUNGS OF CHLORAMINE-T TREATED DOGS

1981 • 6 citations