Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells

Real time quantitative PCR.

1996 • 6,155 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

How cells read TGF-β signals

2000 • 1,843 citations

Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

2000 • 1,445 citations

Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor–II Gene

2000 • 1,184 citations

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

2002 • 1,088 citations

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

2002 • 849 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Primary Pulmonary Hypertension Is Associated With Reduced Pulmonary Vascular Expression of Type II Bone Morphogenetic Protein Receptor

2002 • 653 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

2002 • 602 citations

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

1994 • 558 citations

The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways

2002 • 556 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

Id Genes Are Direct Targets of Bone Morphogenetic Protein Induction in Embryonic Stem Cells

1999 • 514 citations

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

1995 • 510 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

1999 • 419 citations

BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos

2000 • 413 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.

2000 • 364 citations

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

2003 • 319 citations

Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

1999 • 314 citations

Stimulation of Id1 Expression by Bone Morphogenetic Protein Is Sufficient and Necessary for Bone Morphogenetic Protein–Induced Activation of Endothelial Cells

2002 • 303 citations

Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation ofId1 Gene

2002 • 279 citations

Bone Morphogenetic Protein-2 Stimulates Angiogenesis in Developing Tumors

2004 • 272 citations

From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family

2003 • 270 citations

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

2002 • 267 citations

The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly

2003 • 264 citations

BMP2-induced Apoptosis Is Mediated by Activation of the TAK1-p38 Kinase Pathway That Is Negatively Regulated by Smad6

2000 • 242 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

BMPs signal alternately through a SMAD or FRAP–STAT pathway to regulate fate choice in CNS stem cells

2003 • 207 citations

Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2

1999 • 206 citations

Controlling cell fate by bone morphogenetic protein receptors

2003 • 205 citations

Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro

2000 • 142 citations

Functional Heterogeneity of Bone Morphogenetic Protein Receptor-II Mutants Found in Patients with Primary Pulmonary Hypertension

2002 • 131 citations

Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension

2003 • 129 citations

Krüppel-like Factor 4 (KLF4/GKLF) Is a Target of Bone Morphogenetic Proteins and Transforming Growth Factor β1 in the Regulation of Vascular Smooth Muscle Cell Phenotype

2003 • 118 citations

Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues.

2000 • 104 citations

BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells

2004 • 97 citations

Molecular cloning and binding properties of the human type II activin receptor

1992 • 84 citations

Cooperativity of Binding Epitopes and Receptor Chains in the BMP/TGFß Superfamily

2001 • 84 citations

Identification of a Novel Redox-Sensitive Gene, Id3, Which Mediates Angiotensin II–Induced Cell Growth

2002 • 82 citations

Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells

2004 • 77 citations

Smooth Muscle α-Actin Gene Requires Two E-Boxes for Proper Expression In Vivo and Is a Target of Class I Basic Helix-Loop-Helix Proteins

2003 • 72 citations

Emerging roles for bone morphogenetic proteins in central nervous system glial biology

2004 • 69 citations

Characterization of the Bone Morphogenetic Protein (BMP) System in Human Pulmonary Arterial Smooth Muscle Cells Isolated from a Sporadic Case of Primary Pulmonary Hypertension: Roles of BMP Type IB Receptor (Activin Receptor-Like Kinase-6) in the Mitotic Action

2004 • 48 citations

Generation of a floxed allele of the mouse BMP type II receptor gene

2005 • 45 citations

Phosphorylation Regulates Id3 Function in Vascular Smooth Muscle Cells

2004 • 28 citations