The elevated T-maze as an experimental model of anxiety

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

5-HT and mechanisms of defence

1991 • 1,017 citations

Role of 5-HT in stress, anxiety, and depression

1996 • 972 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

The relation between fear induced by novel stimulation and exploratory drive.

1955 • 900 citations

Anxiogenic stimuli in the elevated plus-maze

1993 • 626 citations

Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: Most antidepressants selectively block norepinephrine uptake

1984 • 528 citations

SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

1997 • 519 citations

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

1995 • 497 citations

Observational conditioning of snake fear in rhesus monkeys.

1984 • 412 citations

Experimental Approaches to Anxiety and Depression

1993 • 358 citations

Lasting effects on rodent anxiety of a single exposure to a cat

1993 • 349 citations

Evidence that mCPP may have behavioural effects mediated by central 5‐HT_1C receptors

1988 • 299 citations

Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders

1986 • 280 citations

The elevated T-maze: A new animal model of anxiety and memory

1994 • 265 citations

5HT drugs in animal models of anxiety

1993 • 261 citations

Serotonin and anxiety revisited

1988 • 253 citations

The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam.

1993 • 248 citations

The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines

1995 • 213 citations

Dual role of 5-HT in defense and anxiety

1997 • 199 citations

Fenfluramine provocation of anxiety in patients with panic disorder

1989 • 196 citations

In vivo properties of SB 200646A, a 5‐HT_2C/2B receptor antagonist

1994 • 182 citations

5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions

1993 • 168 citations

Mechanisms of effects of d-Fenfluramine on brain serotonin metabolism in rats: Uptake inhibition versus release

1988 • 157 citations

New concepts in anxiety

1990 • 157 citations

Multiple serotonin mechanisms in animal models of anxiety

1993 • 152 citations

The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines

1994 • 139 citations

Fear of snakes in wild- and laboratory-reared rhesus monkeys (Macaca mulatta)

1980 • 134 citations

Maintenance Drug Treatment of Panic Disorder

1993 • 122 citations

Treatment of spontaneous panic attacks with chlomipramine

1981 • 115 citations

Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.

1992 • 114 citations

Effect of chlorimipramine and maprotiline on experimental anxiety in humans

1987 • 113 citations

Dexfenfluramine

1992 • 113 citations

Effects of the 5‐HT_2B receptor agonist, BW 723C86, on three rat models of anxiety

1996 • 108 citations

Amino Acids in Fossil Human Bone

1957 • 99 citations

Yohimbine's anxiogenic action: Evidence for noradrenergic and dopaminergic sites

1989 • 93 citations

Noradrenergic function in generalized anxiety disorder: Effects of yohimbine in healthy subjects and patients with generalized anxiety disorder

1989 • 91 citations

Dexfenfluramine and serotonin neurotoxicity: further preclinical evidence that clinical caution is indicated.

1994 • 87 citations

Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated T-maze

1996 • 87 citations

Animal models of different anxiety states.

1995 • 77 citations

Neurotransmitters in the Dorsal Periaqueductal Grey and Animal Models of Panic Anxiety

1991 • 73 citations

Chlordiazepoxide reduces the generalised anxiety, but not the direct responses, of rats exposed to cat odor

1992 • 72 citations

Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety

1995 • 72 citations

N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist

1993 • 67 citations

Serotonin, sleep and mental disorder

1991 • 66 citations

Anxiolytic effects of serotonergic interventions in the shock-probe burying test and the elevated plus-maze test

1993 • 66 citations

Habituation and generalization of phobic responses to cat odor

1994 • 56 citations

Central serotonin receptors and psychotropic drugs

1992 • 51 citations

Are 5-HT2 antagonists endowed with anxiolytic properties in rodents?

1991 • 43 citations

Effect ofd-fenfluramine on human experimental anxiety

1996 • 42 citations

Anxiety and Its Therapy: Today and Tomorrow

1991 • 37 citations

Behavioural profiles of the reversible monoamine-oxidase-A inhibitors befloxatone and moclobemide in an experimental model for screening anxiolytic and anti-panic drugs

1997 • 30 citations

Novel serotonergic agents.

1993 • 24 citations

Can animal tests of anxiety detect panic‐promoting agents?

1988 • 18 citations

Behavioral effects of the putative anxiolytic (±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) in rats and mice

1996 • 15 citations

5HT2 receptors and anxiety

1995 • 11 citations

RP 62203, a novel naphtosultam derivative with potent and selective 5HT2 antagonist properties: I. Binding and second messenger studies

1990 • 9 citations