Role of 5-HT in stress, anxiety, and depression

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

The Biochemistry of Affective Disorders

1967 • 1,183 citations

5-HT and mechanisms of defence

1991 • 1,017 citations

Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons

1990 • 1,013 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

The relation between fear induced by novel stimulation and exploratory drive.

1955 • 900 citations

Anxiogenic stimuli in the elevated plus-maze

1993 • 626 citations

The prediction of major depression in women: toward an integrated etiologic model

1993 • 564 citations

Animal models of depression: An overview

1990 • 425 citations

Modifications of the Serotonin System by Antidepressant Treatments

1987 • 413 citations

Benzodiazepines: Anxiety-Reducing Activity by Reduction of Serotonin Turnover in the Brain

1972 • 339 citations

Glucocorticoids and the Genesis of Depressive Illness a Psychobiological Model

1994 • 338 citations

5-HT and anxiety

1984 • 325 citations

5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala

1993 • 316 citations

Ethoexperimental Approaches to the Study of Behavior

1989 • 307 citations

Role of the amygdala and periaqueductal gray in anxiety and panic

1993 • 303 citations

The Serotonin-Producing Neurons of the Midbrain Median and Dorsal Raphe Nuclei

1978 • 289 citations

Control and intrusive memories as possible determinants of chronic stress.

1993 • 288 citations

Adrenal Gland Enlargement in Major Depression

1992 • 280 citations

Serotonin receptor binding in a colony model of chronic social stress

1995 • 278 citations

The elevated T-maze: A new animal model of anxiety and memory

1994 • 265 citations

Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression

1993 • 261 citations

Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats

1985 • 255 citations

Serotonin and anxiety revisited

1988 • 253 citations

The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam.

1993 • 248 citations

Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discrimination

1987 • 242 citations

Dual serotoninergic projections to forebrain in the rat: Morphologically distinct 5‐HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives

1991 • 237 citations

Corticosterone enhances long-term retention in one-day-old chicks trained in a weak passive avoidance learning paradigm

1994 • 236 citations

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

1987 • 230 citations

5-Hydroxytryptamine and punishment

1977 • 229 citations

Neurobiological Mechanisms Involved in Antidepressant Therapies

1993 • 211 citations

The Vulnerability of the Hippocampus to Protective and Destructive Effects of Glucocorticoids in Relation to Stress

1992 • 202 citations

Dual role of 5-HT in defense and anxiety

1997 • 199 citations

Fenfluramine provocation of anxiety in patients with panic disorder

1989 • 196 citations

Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin

1990 • 194 citations

Autoradiographic Analyses of the Effects of Adrenalectomy and Corticosterone on 5-HT<sub>1A</sub> and 5-HT<sub>1B</sub> Receptors in the Dorsal Hippocampus and Cortex of the Rat

1992 • 176 citations

Central serotonergic responses and behavioural adaptation to repeated immobilisation: The effect of the corticosterone synthesis inhibitor metyrapone

1985 • 172 citations

The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.

1993 • 168 citations

Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons

1991 • 167 citations

Hippocampal Noradrenaline and Serotonin Release over 24 Hours as Measured by the Dialysis Technique in Freely Moving Rats: Correlation to Behavioural Activity State, Effect of Handling and Tail‐Pinch

1989 • 165 citations

Brain 5-HT1 binding sites in depressed suicides

1990 • 165 citations

New concepts in anxiety

1990 • 157 citations

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors

1992 • 149 citations

Simulated public speaking as a model of clinical anxiety

1982 • 142 citations

Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices

1992 • 137 citations

A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation

1990 • 133 citations

The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.

1993 • 132 citations

Treatment of Major Depression with metyrapone and hydrocortisone

1995 • 129 citations

Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain

1992 • 127 citations

The hypothalamic lateral tuberal nucleus and the characteristics of neuronal loss in Huntington's disease

1991 • 124 citations

Cortisol synthesis inhibition: A new treatment strategy for the clinical and endocrine manifestations of depression

1995 • 121 citations

Effects of ritanserin on aversive classical conditioning in humans

1991 • 114 citations

Hippocampal 5-HT receptors and consolidation of stressful memories

1993 • 113 citations

Dexfenfluramine

1992 • 113 citations

Social isolation attenuates rat forebrain 5-HT release induced by KCl stimulation and exposure to a novel environment

1993 • 112 citations

Effects of median raphe nucleus lesions on hippocampal EEG in the freely moving rat

1979 • 111 citations

Effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression

1994 • 109 citations

Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test

1989 • 108 citations

Behavioural evidence for a functional interaction between central 5‐HT₂ and 5‐HT_1A receptors

1990 • 102 citations

Role of 5-HT in Defensive Behavior and Anxiety

1993 • 96 citations

The Impact of Stressors on Immune and Central Neurotransmitter Activity: Bidirectional Communication

1993 • 94 citations

Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated T-maze

1996 • 87 citations

Central Serotonin Receptors and Psychotropic Drugs

1993 • 86 citations

Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection

1992 • 84 citations

8-Hydroxy-2-(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, impairs performance in a passive avoidance task

1992 • 77 citations

Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT

1994 • 77 citations

Stimulation of 5-HT1A receptors in the dorsal hippocampus impairs acquisition and performance of a spatial task in a water maze

1992 • 77 citations

Reduced 5-hydroxytryptamine-dependent behaviour in rats following chronic corticosterone treatment

1985 • 74 citations

Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testing.

1994 • 70 citations

Buspirone affects hippocampal rhythmical slow activity through serotonin1A rather than dopamine D2 receptors

1991 • 69 citations

Inhibitory modulation of long-term potentiation via the 5-HT1A receptor in slices of the rat hippocampal dentate gyrus

1993 • 64 citations

p-Chloroamphetamine (PCA), 3,4-methylenedioxymethamphetamine (MDMA) andd-fenfluramine pretreatment attenuatesd-fenfluramine-evoked release of 5-HT in vivo

1994 • 58 citations

Regulation of Hippocampal 5-HT1A Receptor Gene Expression by Dexamethasone

1994 • 56 citations

Chlordiazepoxide microinjected into the region of the dorsal raphe nucleus eliminates the interference with escape responding produced by inescapable shock whether administered before inescapable shock or escape testing.

1994 • 53 citations

Chlordiazepoxide and GABA injected into raphé dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive component

1980 • 53 citations

Central serotonin receptors and psychotropic drugs

1992 • 51 citations

Characterization of a psychophysiological model of classical fear conditioning in healthy volunteers: influence of gender, instruction, personality and placebo

1991 • 48 citations

Serotonin inhibits induction of long-term potentiation at commissural synapses in hippocampus

1993 • 48 citations

The Neurobiology of Anxiety

1990 • 46 citations

Role of hippocampal 5-HT1A receptors on elevated plus maze exploration after a single restraint experience

1996 • 45 citations

Involvement of corticosteroids in the processing of stressful life-events. A possible implication for the development of depression

1994 • 44 citations

The Relationship of Life Adversity, Social Support, and Coping to Hospitalization with Major Depression

1992 • 44 citations

Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome

1990 • 42 citations

The involvement of glucocorticoids in the acquired immobility response is dependent on the water temperature

1992 • 40 citations

Differential effect of subchronic dexamethasone treatment on serotonin-2 and β-adrenergic receptors in the rat cerebral cortex and hippocampus

1993 • 39 citations

Anxiety and Its Therapy: Today and Tomorrow

1991 • 37 citations

Chemical Pathways in the Brain

1978 • 30 citations

Modification of central serotonergic and dopaminergic behaviors in the course of chronic corticosteroid administration

1982 • 28 citations

Attenuation of behavioral consequences of immobilization stress by intra-hippocampal microinjection of zimelidine.

1993 • 25 citations

Prolactin response to fenfluramine and placebo challenge following maintenance pharmacotherapy withdrawal in remitted depressed patients

1993 • 25 citations

5 ht receptor subtypes and the modulation of aversion

1992 • 25 citations

Working memory deficits induced by intrahippocampal administration of 8-OH-DPAT, a 5-HT1A receptor agonist, in the rat

1993 • 24 citations

Stress-induced expression of the c-fos proto-oncogene in the hippocampal formation.

1994 • 21 citations

Adrenergic regulation of [3H]ketanserin binding sites during immobilization stress in the rat frontal cortex

1990 • 21 citations

Microinjections of methyl-β-carboline-3-carboxylate into the dorsal raphe nucleus: Behavioural consequences

1986 • 18 citations

5HT1A Agonists, 5HT3 Antagonists and Benzodiazepines

1991 • 17 citations

Adrenal hormones in rats before and after stress-experience: Effects of ipsapirone

1992 • 17 citations

5-HT Receptor Mechanisms in Human Anxiety

1991 • 13 citations

D-fenfluramine reduces anxiety induced by simulated public speaking.

1993 • 13 citations

5HT2 receptors and anxiety

1995 • 11 citations

D-fenfluramine selectively releases 5-HT from dorsal raphe terminals.

1996 • 11 citations

Ulcerogenic effect of the lesion of the median raphe nucleus in fasted rats.

1986 • 10 citations

Serotoninergic depression of auditory evoked responses recorded in the rat hippocampus: effect of repeated buspirone treatment

1992 • 9 citations