5-HT and mechanisms of defence

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

1978 • 1,887 citations

Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear

1988 • 1,573 citations

The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning

1990 • 1,134 citations

Serotonergic Studies in Patients With Affective and Personality Disorders

1989 • 1,093 citations

HIPPOCAMPAL PROJECTIONS AND RELATED NEURAL PATHWAYS TO THE MID-BRAIN IN THE CAT

1958 • 982 citations

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

A perceptual-defensive-recuperative model of fear and pain

1980 • 811 citations

Innate and conditioned reactions to threat in rats with amygdaloid lesions.

1972 • 739 citations

Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues

1991 • 581 citations

Organization of the amygdalopetal projections from modality‐specific cortical association areas in the monkey

1980 • 533 citations

Modifications of the Serotonin System by Antidepressant Treatments

1987 • 413 citations

Organization of the subcortical system governing defence and flight reactions in the cat

1962 • 376 citations

The organization of divergent axonal projections from the midbrain raphe nuclei in the rat

1986 • 366 citations

Neuroanatomical Correlates of a Lactate-Induced Anxiety Attack

1989 • 326 citations

Serotonin, memory, and the aging brain

1991 • 287 citations

Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders

1986 • 280 citations

Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in rats

1985 • 255 citations

Learning Motivated by Electrical Stimulation of the Brain

2017 • 250 citations

The psychopharmacology of 5-HT3 receptors

1990 • 246 citations

Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discrimination

1987 • 242 citations

Plasma prolactin changes following fenfluramine in depressed patients compared to controls: An evaluation of central serotonergic responsibility in depression

1984 • 241 citations

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

1987 • 230 citations

Theory in Psychopharmacology

1982 • 229 citations

Catecholamine-containing neurones and electrical self-stimulation: 2. A theoretical interpretation and some psychiatric implications

1973 • 218 citations

Neurotic illness and its response to anxiolytic and antidepressant treatment

1980 • 216 citations

Mesocorticolimbic Dopamine Systems and Reward

1988 • 207 citations

What facial features activate face neurons in the inferotemporal cortex of the monkey?

1988 • 204 citations

Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin

1990 • 194 citations

Correspondence between 5-HT2 receptors and serotonergic axons in rat neocortex

1988 • 193 citations

Selective Control by Corticosterone of Serotonin Receptor Capacity in Raphe-Hippocampal System

1986 • 180 citations

Emotional Behavior Produced by Hypothalamic Stimulation

1958 • 177 citations

Brain 5-HT1 binding sites in depressed suicides

1990 • 165 citations

Anti-aversive role of serotonin in the dorsal periaqueductal grey matter

1985 • 160 citations

Drug treatment of panic disorder: the comparative efficacy of imipramine, alprazolam, and trazodone.

1986 • 149 citations

Differential effects of lesions in medial and dorsal raphe of the rat: Latent inhibition and septohippocampal serotonin levels.

1980 • 143 citations

Hypercortisolism Among Socially Subordinate Wild Baboons Originates at the CNS Level

1989 • 133 citations

A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation

1990 • 133 citations

The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: A possible role for 5-HT1A receptors in memory

1987 • 127 citations

Role of the periaqueductal gray substance in the antianxiety action of benzodiazepines

1978 • 126 citations

Dominant social status facilitates the behavioral effects of serotonergic agonists

1985 • 124 citations

Monoaminergic mechanisms in aversive brain stimulation

1975 • 123 citations

Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat

1987 • 122 citations

Enhanced behavioral conditioning to context and impaired behavioral and neuroendocrine responses to conditioned stimuli following ceruleocortical noradrenergic lesions: support for an attentional hypothesis of central noradrenergic function

1990 • 118 citations

Handbook of psychiatry

1974 • 115 citations

Buspirone impairment of performance of passive avoidance and spatial learning tasks in the rat

1990 • 114 citations

Neuro-Psychopharmacology

1962 • 114 citations

Effects of ritanserin on aversive classical conditioning in humans

1991 • 114 citations

Effect of chlorimipramine and maprotiline on experimental anxiety in humans

1987 • 113 citations

Antidepressant-like action of 8-OH-DPAT, a 5-HT1A agonist, in the learned helplessness paradigm: evidence for a postsynaptic mechanism

1990 • 107 citations

Corticosterone modulation of neurotransmitter receptors in rat hippocampus: A quantitative autoradiographic study

1985 • 104 citations

Behavioural evidence for a functional interaction between central 5‐HT₂ and 5‐HT_1A receptors

1990 • 102 citations

Hormonal responses to fenfluramine in depressed and control subjects

1990 • 99 citations

Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus

1985 • 95 citations

5HT2 receptors, depression and anxiety

1988 • 88 citations

Evidence of Pavlovian conditioned fear following electrical stimulation of the periaqueductal grey in the rat

1987 • 88 citations

5-HT1A Receptors in Anxiety

1991 • 81 citations

An important role of the central amygdaloid nucleus and mammillary body in the mediation of conflict behavior in rats

1986 • 76 citations

Reduced 5-hydroxytryptamine-dependent behaviour in rats following chronic corticosterone treatment

1985 • 74 citations

Dorsal raphe nucleus stimulation reduces centrally-elicited fearlike behavior

1980 • 71 citations

A neuropharmacological study of the periventricular neural substrate involved in flight

1986 • 67 citations

The importance of serotonergic mechanisms for the induction of hyperactivity by amphetamine and its antagonism by intra-accumbens (3,4-dihydroxy-phenylamino)-2-imidazoline (DPI)

1979 • 67 citations

Social psychiatry : theory, methodology, and practice

1991 • 65 citations

The neuroendocrine response to fenfluramine in depressives and normal controls

1988 • 65 citations

Destruction of 5-hydroxytryptaminergic neurons and the dynamics of dopamine in nucleus accumbens septi and other forebrain regions of the rat

1981 • 57 citations

Relaxation-induced panic (RIP): When resting isn't peaceful.

1987 • 56 citations

Reduction in cortical 5HT2 receptor sensitivity after continuous gepirone treatment

1985 • 56 citations

Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion

1989 • 54 citations

Pindolol decreases prolactin and growth hormone responses to intravenousL-tryptophan

1991 • 51 citations

The Fenfluramine Challenge Test in the Affective Spectrum: A Possible Marker of Endogeneity and Severity

1988 • 44 citations

Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome

1990 • 42 citations

Separation of the associative and non-associative effects of brain serotonin released by p-chloroamphetamine: Dissociable serotoninergic involvement in avoidance learning, pain and motor function

1985 • 42 citations

Blunted growth hormone and prolactin responses to L-tryptophan in depression; a state-dependent abnormality

1991 • 40 citations

Ascending 5-HT pathways and behavioural habituation

1979 • 37 citations

Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey

1988 • 35 citations

Effects of isolated housing and chronic antidepressant treatment on cooperative social behaviour in rats

1989 • 33 citations

Modification of central serotonergic and dopaminergic behaviors in the course of chronic corticosteroid administration

1982 • 28 citations

Conditioned suppression of behavior: Its reversal by intra raphe microinjection of chlordiazepoxide and GABA

1980 • 27 citations

The effects of methyl β‐carboline‐3‐carboxylate on social interaction and locomotor activity when microinjected into the nucleus raphé dorsalis of the rat

1985 • 24 citations

Performance of a passive avoidance response is disrupted by compounds acting at 5HT1A receptors

1990 • 23 citations

The definition and psychopharmacology of spontaneous panic and phobia.

1989 • 20 citations

Differential effects of dorsal raphe lesions and intraraphe GABA and benzodiazepines on conflict behavior in rats

1986 • 12 citations

3 (1991) Elective affinities in schizophrenia and childhood autism

2016 • 11 citations

Learning of Object-Object Associations by Monkeys

1983 • 9 citations

Social signalling and schizophrenia: The significance of neurochemical and morphological abnormalities of the basolateral circuit

1991 • 9 citations

Tranquilizer action on thalamic and midbrain escape behavior

1964 • 6 citations

Role of 5HT2 Receptors in Anxiety and Depression

1990 • 3 citations

�ber die H�molyse durch Silbernitrat

1949 • 2 citations