Dexfenfluramine

Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat

1985 • 323 citations

INTERNATIONAL TRIAL OF LONG-TERM DEXFENFLURAMINE IN OBESITY

1989 • 315 citations

Overweight Is Risking Fate

1987 • 297 citations

Serotonin manipulations and the structure of feeding behaviour

1986 • 249 citations

Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats

1979 • 248 citations

Fenfluramine and Fluoxetine Spare Protein Consumption While Suppressing Caloric Intake by Rats

1977 • 235 citations

m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats

1979 • 221 citations

Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system

1986 • 191 citations

The Role of Serotonin in Eating Disorders

1990 • 172 citations

8-OH-DPAT-induced hyperphagia: Its neural basis and possible therapeutic relevance

1986 • 167 citations

8-Hydroxy-2-(Di-n-propylamino)tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons

1986 • 160 citations

Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)

1985 • 160 citations

D- and L-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat

1986 • 146 citations

D-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects

1985 • 127 citations

Carbohydrate craving, obesity and brain serotonin

1986 • 126 citations

FENFLURAMINE AND BRAIN SEROTONIN

1978 • 125 citations

Treatment of seasonal depression with d-fenfluramine.

1989 • 122 citations

Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action.

1988 • 112 citations

Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis

1989 • 107 citations

Anorectic agents lower a body weight set point

1982 • 99 citations

d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression

1991 • 98 citations

The role of putative 5-HT1A and 5-HT1B receptors in the control of feeding in rats

1987 • 96 citations

Weight gain and withdrawal symptoms after smoking cessation: A preventive intervention using d-fenfluramine.

1991 • 93 citations

Reduction of Food Intake by Manipulation of Central Serotonin Current Experimental Results

1989 • 82 citations

D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain

1989 • 79 citations

Effect of naloxone and naltrexone on the development of satiation measured in the runway: Comparisons with d-amphetamine and d-fenfluramine

1986 • 79 citations

Pulmonary hypertension and dexfenfluramine

1992 • 76 citations

Dexfenfluramine neurotoxicity in brains of non-human primates

1991 • 75 citations

Progress in assessing the role of serotonin in the control of food intake.

1988 • 72 citations

Species differences in the kinetics and metabolism of fenfluramine isomers.

1982 • 68 citations

Effect of d-fenfluramine on serotonin release in brains of anaesthetized rats

1989 • 63 citations

Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.

1990 • 61 citations

Carbohydrate Craving

1990 • 56 citations

D-fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain

1982 • 54 citations

d-Fenfluramine selectively decreases carbohydrate but not protein intake in obese subjects.

1984 • 53 citations

Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and dl-fenfluramine for 15 days

1985 • 50 citations

Food intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969

1990 • 46 citations

Effect of dexfenfluramine on body weight set-point: Study in the rat with hoarding behaviour

1986 • 46 citations

The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet

1984 • 44 citations

Effects of repeated administration of serotonergic agonists on diet selection and body weight in rats

1991 • 42 citations

Dopaminergic and serotoninergic anorectics differentially antagonize insulin- and 2-DG-induced hyperphagia

1985 • 39 citations

On the mechanism of action of dexfenfluramine: effect on alliesthesia and appetite motivation in lean and obese subjects.

1988 • 37 citations

Modulation of the thermic effect of food by fenfluramine.

1986 • 36 citations

Effects of methiothepin on changes in brain serotonin release induced by repeated administration of high doses of anorectic serotonenergic drugs

1992 • 33 citations

Effect of (+)- or (−)-enantiomers of fenfluramine or norfenfluramine on nutrient selection by rats

1982 • 32 citations

Carbohydrate cravings: a disorder of food intake and mood.

1988 • 31 citations

Eating caused by neuropeptide-Y injection in the paraventricular hypothalamus: response to (+)-fenfluramine and (+)-amphetamine in rats

1987 • 31 citations

Efficacy and safety of dexfenfluramine in obese patients: a multicenter study.

1988 • 29 citations

Differential effects of d-fenfluramine and p-chloroamphetamine on H7512-induced depletion of 5-hydroxytryptamine and dopamine in the rat brain

1991 • 29 citations

Different effects of fenfluramine isomers and metabolites on extracellular 5-HIAA in nucleus accumbens and hippocampus of freely moving rats

1988 • 28 citations

Metabolic mechanism of the anorectic and leptogenic effects of the serotonin agonist fenfluramine

1986 • 28 citations

Tolerance to fenfluramine anorexia: Fact or fiction?

1986 • 27 citations

Feeding and satiation observed in the runway: the effects of d-amphetamine and d-fenfluramine compared

1983 • 26 citations

Long term actions of d-fenfluramine in two rat models of obesity. I Sustained reductions in body weight and adiposity without depletion of brain serotonin.

1989 • 23 citations

Effect of 6 months therapy with dexfenfluramine in obese patients: studies in the United Kingdom.

1988 • 23 citations

IS RECEPTOR ACTIVATION INVOLVED IN THE MECHANISM BY WHICH (+)‐FENFLURAMINE AND (+)‐NORFENFLURAMINE DEPLETE 5‐HYDROXYTRYPTAMINE IN THE RAT BRAIN?

1982 • 22 citations

Repeated treatment with d-fenfluramine or metergoline alters cortex binding of 3H-serotonin and serotonergic sensitivity in rats

1980 • 20 citations

Management of Catatonic Stupor with L-Dopa

1988 • 20 citations

Prolonged use of a very low calorie diet (Cambridge diet) in massively obese patients attending an obesity clinic: safety, efficacy and additional benefit from dexfenfluramine.

1989 • 19 citations

Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with d-fenfluramine

1989 • 17 citations

Characterization of high affinity and stereospecific binding to rat brain

1988 • 15 citations

Lipostatic and ischymetric mechanisms originate dexfenfluramine-induced anorexia

1988 • 14 citations

Management Strategies for Weight Control

1990 • 12 citations

Enhancement of the thermic effect of food by d-fenfluramine.

1988 • 12 citations

Effect of dexfenfluramine on gastric emptying of a mixed solid-liquid meal in obese subjects

1990 • 11 citations

Brain serotonin and carbohydrate craving in obesity.

1987 • 9 citations

Effects of d-amphetamine and d-fenfluramine on performance of rats in a food maze

1984 • 9 citations

Role of 5-HT receptors in the effect of d-fenfiuramine on gastric emptying and feeding behaviour as examined in the runway test

1991 • 9 citations

The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine in human feeding.

1988 • 8 citations

Permanent administration of d-fenfluramine in rats: paradoxical effects.

1988 • 4 citations