Group VIA Phospholipase A2 Forms a Signaling Complex with the Calcium/Calmodulin-dependent Protein Kinase IIβ Expressed in Pancreatic Islet β-Cells

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2002 • 1,855 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

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The growing phospholipase A2 superfamily of signal transduction enzymes

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Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

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Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase

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Neuronal Ca²⁺/Calmodulin-Dependent Protein Kinase II: The Role of Structure and Autoregulation in Cellular Function

2002 • 634 citations

Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins

1990 • 528 citations

A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs

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Exocytosis elicited by action potentials and voltage‐clamp calcium currents in individual mouse pancreatic B‐cells.

1993 • 272 citations

A novel mechanism for the store-operated calcium influx pathway

2004 • 263 citations

Global expression analysis of gene regulatory pathways during endocrine pancreatic development

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Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells.

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Learning Mechanisms: The Case for CaM-KII

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A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca²⁺/Calmodulin-Dependent Kinase II

2003 • 146 citations

Ca2+-independent Phospholipase A2 Is a Novel Determinant of Store-operated Ca2+ Entry

2003 • 144 citations

Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of langerhans

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Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in .beta.-cell cytosolic calcium ion concentration

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Uptake and Release of Ca2+ by the Endoplasmic Reticulum Contribute to the Oscillations of the Cytosolic Ca2+ Concentration Triggered by Ca2+ Influx in the Electrically Excitable Pancreatic B-cell

1999 • 129 citations

Regional Distribution, Ontogeny, Purification, and Characterization of the Ca²⁺‐Independent Phospholipase A₂ from Rat Brain

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Identification of the Ankyrin-binding Domain of the Mouse T-lymphoma Cell Inositol 1,4,5-Trisphosphate (IP3) Receptor and Its Role in the Regulation of IP3-mediated Internal Ca2+ Release

1995 • 127 citations

CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis.

1999 • 126 citations

Inactivation of the sarcoplasmic reticulum calcium channel by protein kinase

1992 • 124 citations

Depletion of Intracellular Calcium Stores Activates Smooth Muscle Cell Calcium-independent Phospholipase A2

1997 • 122 citations

Studies of the Role of Group VI Phospholipase A2 in Fatty Acid Incorporation, Phospholipid Remodeling, Lysophosphatidylcholine Generation, and Secretagogue-induced Arachidonic Acid Release in Pancreatic Islets and Insulinoma Cells

1999 • 118 citations

Pancreatic Islets Express a Ca2+-independent Phospholipase A2 Enzyme That Contains a Repeated Structural Motif Homologous to the Integral Membrane Protein Binding Domain of Ankyrin

1997 • 112 citations

Ankyrins: structure and function in normal cells and hereditary spherocytes.

1993 • 111 citations

Characterization of a Ca2+ Release-activated Nonselective Cation Current Regulating Membrane Potential and [Ca2+] Oscillations in Transgenically Derived β-Cells

1998 • 110 citations

Hydrogen Peroxide Induces Intracellular Calcium Overload by Activation of a Non-selective Cation Channel in an Insulin-secreting Cell Line

1999 • 108 citations

Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2

2001 • 102 citations

The molecular biology of the group VIA Ca2+-independent phospholipase A2

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Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues.

1992 • 94 citations

Long‐term potentiation requires activation of calcium‐independent phospholipase A₂

1995 • 94 citations

Expression, Purification, and Kinetic Characterization of a Recombinant 80-kDa Intracellular Calcium-independent Phospholipase A2

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Identification of the Calmodulin-binding Domain of Recombinant Calcium-independent Phospholipase A2β

2001 • 92 citations

The Calcium-dependent Association and Functional Coupling of Calmodulin with Myocardial Phospholipase A2

1996 • 89 citations

Studies of Insulin Secretory Responses and of Arachidonic Acid Incorporation into Phospholipids of Stably Transfected Insulinoma Cells That Overexpress Group VIA Phospholipase A2(iPLA2β) Indicate a Signaling Rather Than a Housekeeping Role for iPLA2β

2001 • 83 citations

Phospholipase A2 activity in pancreatic islets is calcium-dependent and stimulated by glucose

1982 • 80 citations

Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: Prominence of plasmenylethanolamine molecular species

1993 • 77 citations

AnkyrinG is associated with the postsynaptic membrane and the sarcoplasmic reticulum in the skeletal muscle fiber

1998 • 74 citations

Presence and Possible Involvement of Ca/Calmodulin-Dependent Protein Kinases in Insulin Release from the Rat Pancreatic βCell

1993 • 74 citations

Glucose activates the multifunctional Ca2+/calmodulin-dependent protein kinase II in isolated rat pancreatic islets.

1994 • 69 citations

Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet .beta.-cells and subcellular membranes

1993 • 62 citations

Mass Spectrometric Evidence That Agents That Cause Loss of Ca2+ from Intracellular Compartments Induce Hydrolysis of Arachidonic Acid from Pancreatic Islet Membrane Phospholipids by a Mechanism That Does Not Require a Rise in Cytosolic Ca2+ Concentration**This work was supported by U.S. Public Health Service grants PO1-HL57278, P41-RR-00954, and S10-RR-11260 and by an American Diabetes Association Career Development Award (S.R.).

1998 • 61 citations

Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets

1992 • 56 citations

Inhibition of phospholipase A2 and insulin secretion in pancreatic islets

1992 • 55 citations

Calmodulin-activated protein kinase activity in rat pancreatic islet cell membranes

1982 • 52 citations

A novel pancreatic β‐cell isoform of calcium/calmodulin‐dependent protein kinase II (β₃isoform) contains a proline‐rich tandem repeat in the association domain

1995 • 50 citations

Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol.

1998 • 41 citations

Transient activation of calcium-dependent phospholipase A2 by insulin secretagogues in isolated pancreatic islets

1993 • 36 citations

Dependence of insulin secretion from permeabilized pancreatic β-cells on the activation of Ca2+/calmodulin-dependent protein kinase II

2000 • 35 citations

Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II

1992 • 35 citations

The Calcimimetic R-467 Potentiates Insulin Secretion in Pancreatic β Cells by Activation of a Nonspecific Cation Channel

2000 • 34 citations

A Specific Inhibitor of Cytosolic Phospholipase A2Activity, AACOCF3, Inhibits Glucose-Induced Insulin Secretion from Isolated Rat Islets

1996 • 34 citations

Site-specific phosphorylation of synapsin I by Ca2+/calmodulin-dependent protein kinase II in pancreatic betaTC3 cells: synapsin I is not associated with insulin secretory granules.

1999 • 33 citations

Ca2+-Calmodulin-dependent Protein Kinase II Potentiates Store-operated Ca2+ Current

2003 • 32 citations

Regulation of Insulin Secretion by Overexpression of Ca²⁺/Calmodulin-Dependent Protein Kinase II in Insulinoma MIN6 Cells

2000 • 32 citations

Phasic Effects of Glucose, Phospholipase A₂, and Lysophospholipids on Insulin Secretion*

1987 • 31 citations

Correlation of the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II with the Initiation of Insulin Secretion from Perifused Pancreatic Islets*

1997 • 31 citations

Glucose-induced alterations in β-cell cytoplasmic Ca2+ involving the coupling of intracellular Ca2+ stores and plasma membrane ion channels

1997 • 29 citations

Cloning and quantitative determination of the human Ca 2+ /calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells

2000 • 26 citations

Ca2+/Calmodulin Inhibition and Phospholipase C-Linked Ca2+ Signaling in Clonalβ -Cells1

1999 • 11 citations

Alterations in Calcium Channel Currents Underlie Defective Insulin Secretion in a Transgenic Mouse

1996 • 6 citations