Dependence of insulin secretion from permeabilized pancreatic β-cells on the activation of Ca2+/calmodulin-dependent protein kinase II

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats

1963 • 2,254 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Calmodulin Is the Ca2+ Sensor for Ca2+-Dependent Inactivation of L-Type Calcium Channels

1999 • 822 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

The newly synthesized selective Ca2+calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

1991 • 497 citations

A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions

1982 • 331 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation

1989 • 293 citations

A Novel Highly Specific and Potent Inhibitor of Calmodulin-Dependent Protein Kinase II

1995 • 284 citations

Ca²⁺-induced inhibition of the cardiac Ca²⁺channel depends on calmodulin

1999 • 276 citations

Exocytosis elicited by action potentials and voltage‐clamp calcium currents in individual mouse pancreatic B‐cells.

1993 • 272 citations

Reversible generation of a Ca2+-independent form of Ca2+(calmodulin)-dependent protein kinase II by an autophosphorylation mechanism.

1986 • 270 citations

VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion.

1995 • 223 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines

1992 • 216 citations

Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.

1994 • 215 citations

KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.

1998 • 213 citations

Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.

1994 • 186 citations

The effect of Ca²⁺–calmodulin‐dependent protein kinase II on cardiac excitation–contraction coupling in ferret ventricular myocytes

1997 • 162 citations

Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of langerhans

1979 • 142 citations

CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis.

1999 • 126 citations

Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.

1992 • 124 citations

The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic β-cells: action of synaptotagmin at low micromolar calcium

1997 • 109 citations

Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues.

1992 • 94 citations

Calcium-stimulated Phosphorylation of MAP-2 in Pancreatic ॆTC3-cells Is Mediated by Ca2+/Calmodulin-dependent Kinase II

1997 • 85 citations

[Immunoassay of insulin].

1968 • 77 citations

Presence and Possible Involvement of Ca/Calmodulin-Dependent Protein Kinases in Insulin Release from the Rat Pancreatic βCell

1993 • 74 citations

Measurement of Rat Insulin: Enzyme-Linked Immunosorbent Assay With Increased Sensitivity, High Accuracy, and Greater Practicability Than Established Radioimmunoassay

1988 • 73 citations

Glucose activates the multifunctional Ca2+/calmodulin-dependent protein kinase II in isolated rat pancreatic islets.

1994 • 69 citations

Protein phosphorylation and beta-cell function

1994 • 61 citations

Cloning from Insulinoma Cells of Synapsin I Associated with Insulin Secretory Granules

1999 • 46 citations

Insulinoma Cells Contain an Isoform of Ca2+/Calmodulin-Dependent Protein Kinase II δ Associated with Insulin Secretion Vesicles*

1997 • 40 citations

Ca/Calmodulin-dependent kinase II inhibitor KN62 attenuates glutamate release by inhibiting voltage-dependent Ca2+-channels

1995 • 39 citations

Site-specific phosphorylation of synapsin I by Ca2+/calmodulin-dependent protein kinase II in pancreatic betaTC3 cells: synapsin I is not associated with insulin secretory granules.

1999 • 33 citations

Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue

1999 • 32 citations

Correlation of the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II with the Initiation of Insulin Secretion from Perifused Pancreatic Islets*

1997 • 31 citations

Multisite control of insulin release by glucose.

1994 • 26 citations

Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay

1988 • 22 citations

Ca²⁺/Calmodulin‐Dependent Protein Kinase II Inhibitor KN‐62 Inhibits Adrenal Medullary Chromaffin Cell Functions Independent of Its Action on the Kinase

1996 • 21 citations

Inhibition of agonist-mediated calcium entry by calmodulin antagonists and by the Ca2+/calmodulin kinase II inhibitor KN-62. Studies with thyroid FRTL-5 cells

1996 • 21 citations

Dephosphorylation and deactivation of Ca2+/calmodulin-dependent protein kinase II in βTC3-cells is mediated by Mg2+- and okadaic-acid-sensitive protein phosphatases

1998 • 21 citations

KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells

1996 • 20 citations

Muscarinic activation of Ca2+/calmodulin-dependent protein kinase II in pancreatic islets. Temporal dissociation of kinase activation and insulin secretion

1996 • 17 citations

Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells

1997 • 15 citations

Ca²⁺-induced loss of Ca²⁺/calmodulin-dependent protein kinase II activity in pancreatic β-cells

1998 • 9 citations

The imidazoline derivative calmidazolium inhibits voltage-gated Ca2+-channels and insulin release but has no effect on the phospholipase C system in insulin producing RINm5F-cells

1994 • 8 citations

Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue

1999 • 7 citations

Correlation of the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II with the Initiation of Insulin Secretion from Perifused Pancreatic Islets

1997 • 7 citations

Insulinoma Cells Contain an Isoform of Ca2+/Calmodulin-Dependent Protein Kinase II Associated with Insulin Secretion Vesicles

1997 • 5 citations