Hydrogen Peroxide Induces Intracellular Calcium Overload by Activation of a Non-selective Cation Channel in an Insulin-secreting Cell Line

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1997 • 1,144 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases

1998 • 580 citations

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

Calcium-Mediated Mechanisms in Chemically Induced Cell Death

1992 • 518 citations

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse

1981 • 502 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

Modification of human red cells by virus action; agglutination by incomplete Rh antibody.

1947 • 339 citations

Intracellular calibration of the fluorescent calcium indicator Fura-2

1990 • 280 citations

Hydrogen Peroxide Stimulates the Ca2+ Release Channel from Skeletal Muscle Sarcoplasmic Reticulum

1995 • 258 citations

Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro

1979 • 206 citations

Increased Activity of L-Type Ca ²⁺ Channels Exposed to Serum from Patients with Type I Diabetes

1993 • 188 citations

Free Radicals in the Genesis of Alzheimer's Diseasea

1993 • 171 citations

Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells

1992 • 164 citations

Inhibition of Alloxan Action in Isolated Pancreatic Islets by Superoxide Dismutase, Catalase, and a Metal Chelator

1980 • 159 citations

Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells.

1994 • 156 citations

Calcium and neuronal death

2005 • 112 citations

Molecular basis of experimental diabetes: Degeneration, oncogenesis and regeneration of pancreatic B‐cells of islets of Langerhans

1985 • 110 citations

Depletion of intracellular Ca2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells.

1994 • 108 citations

Insulin-induced hyperpolarization in mammalian skeletal muscle

1989 • 100 citations

Oxygen free radicals and calcium homeostasis in the heart

1994 • 96 citations

Emptying of Intracellular Ca²⁺ Stores Stimulates Ca²⁺ Entry in Mouse Pancreatic β‐Cells by Both Direct and Indirect Mechanisms

1997 • 82 citations

Effect of carbohydrates upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets

1973 • 80 citations

Neurodegeneration and Neuroprotection in Parkinson's Disease

1996 • 80 citations

Alterations in electrical activity and membrane currents induced by intracellular oxygen-derived free radical stress in guinea pig ventricular myocytes.

1993 • 72 citations

Stimulation of lipid peroxidation increases the intracellular calcium content of isolated hepatocytes

1991 • 69 citations

Activation of a novel non‐selective cation channel by alloxan and H₂O₂ in the rat insulin‐secreting cell line CRI‐G1

1997 • 67 citations

A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.

1998 • 66 citations

Nuclear Ca2+: physiological regulation and role in apoptosis

1994 • 65 citations

Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress

1995 • 61 citations

Five new insulin-producing cell lines with differing secretory properties

1986 • 55 citations

Role of Ca2+ in alloxan-induced pancreatic β-cell damage

1994 • 51 citations

Characterization of a nicotinamide–adenine dinucleotide‐dependent cation channel in the CRI‐G1 rat insulinoma cell line

1997 • 40 citations

Mechanisms of Hydroxyl Free Radical-induced Cellular Injury and Calcium Overloading in Alveolar Macrophages

1993 • 36 citations

The bioelectrical properties of pancreatic islet cells: Effect of diabetogenic agents

1972 • 36 citations

Expression and Characterization of atrplHomolog from Rat

1997 • 36 citations

The Pathogenesis of Free Radical-Induced Calcium Leak in Cultured Rat Cardiomyocytes

1994 • 24 citations

Two novel antioxidants, U74006F and U78517F, inhibit oxidant-stimulated calcium influx

1995 • 21 citations

Alloxan effects on mitochondria: study of oxygen consumption, fluxes of Mg2+, Ca2+, K+ and adenine nucleotides, membrane potential and volume change in vitro

1984 • 20 citations

The effects of pyridine nucleotides on the activity of a calcium-activated nonselective cation channel in the rat insulinoma cell line, CRI-G1

1994 • 14 citations

Oxygen free radicals and calcium homeostasis in the heart

1994 • 12 citations