Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: Prominence of plasmenylethanolamine molecular species

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

ATP-regulated K+ channels in cardiac muscle

1983 • 2,350 citations

Automated Method for Isolation of Human Pancreatic Islets

1988 • 1,282 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

1984 • 1,099 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay

1985 • 716 citations

Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography.

1982 • 533 citations

THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL

1985 • 507 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

Glycolysis Preferentially Inhibits ATP-Sensitive K ⁺ Channels in Isolated Guinea Pig Cardiac Myocytes

1987 • 391 citations

Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP

1985 • 388 citations

Insulin release: The fuel hypothesis

1979 • 351 citations

Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

1985 • 315 citations

Perifusion of Isolated Rat Islets in Vitro: Participation of the Microtubular System in the Biphasic Release of Insulin

1972 • 311 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2.

1991 • 306 citations

High plasmalogen and arachidonic acid content of canine myocardial sarcolemma: a fast atom bombardment mass spectroscopic and gas chromatography-mass spectroscopic characterization

1984 • 295 citations

Improvements in the method of determining individual phospholipids in a complex mixture by successive chemical hydrolyses

1962 • 295 citations

Regulation of arachidonic acid metabolites in macrophages.

1980 • 283 citations

Glucoreceptor mechanisms and the control of insulin release and biosynthesis

1980 • 280 citations

Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids.

1990 • 234 citations

ATP-Sensitive K+ Channels in Pancreatic β-Cells: Spare-Channel Hypothesis

1988 • 220 citations

On the origin of pancreatic endocrine cells

1988 • 195 citations

Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate.

1991 • 189 citations

Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum

1985 • 184 citations

Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.

1987 • 173 citations

Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in .beta.-cell cytosolic calcium ion concentration

1993 • 133 citations

[16] A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of langerhans

1983 • 129 citations

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet .beta.-cells

1993 • 123 citations

Different fatty chain compositions of alkenylacyl, alkylacyl and diacyl phospholipids in rabbit alveolar macrophages: High amounts of arachidonic acid in ether phospholipids

1983 • 118 citations

The molecular species composition of individual diacyl phospholipids in human platelets

1982 • 117 citations

Energy metabolism in islets of Langerhans

1992 • 117 citations

Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin.

1983 • 100 citations

Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids

1983 • 99 citations

ATP-dependent regulation of rabbit myocardial cytosolic calcium-independent phospholipase A2

1991 • 97 citations

DISTRIBUTION QUANTITATIVE DES DIVERS PHOSPHO-LIPIDES DANS LES NEURONES ET LES CELLULES GLIALES ISOLES DU CORTEX CEREBRAL DE RAT ADULTE.

1968 • 93 citations

Characterization and metabolism of ovine foetal lipids

1967 • 91 citations

Insulin Immunoassay by Back-Titration; Some Characteristics of the Technic and the Insulin Precipitant Action of Alcohol

1971 • 91 citations

Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids

1986 • 90 citations

Phospholipase A2 activity in pancreatic islets is calcium-dependent and stimulated by glucose

1982 • 80 citations

Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet beta cells

1992 • 78 citations

Characterization of Voltage-Dependent Ca2+ Channels in β-Cell Line

1989 • 63 citations

Unmasking of arachidonate-induced insulin release by removal of extracellular calcium

1987 • 63 citations

Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells.

1988 • 62 citations

Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets.

1985 • 59 citations

The Pancreatic Islet as Rubik's Cube: Is Phospholipid Hydrolysis a piece of the Puzzle?

1991 • 58 citations

Incorporation and redistribution of arachidonic acid in diacyl and ether phospholipids of bovine aortic endothelial cells

1986 • 50 citations

The role of calcium in phospholipid turnover following glucose stimulation in neonatal rat cultured islets.

1984 • 40 citations

Origin of the Beta Cells of the Islets of Langerhans is Further Questioned by the Expression of Neuronal Intermediate Filament Proteins, Peripherin and NF-L, in the Rat Insulinoma RIN5F Cell Line

1991 • 31 citations

Desensitization of muscle phosphofructokinase to ATP inhibition by removal of a carboxyl-terminal heptadecapeptide.

1987 • 29 citations

Arachidonic acid metabolism in isolated pancreatic islets VI. Carbohydrate insulin secretagogues must be metabolized to induce eicosanoid release

1992 • 27 citations

Fatty acid composition of diacyl, alkylacyl, and alkenylacyl phospholipids of control and arachidonate-depleted rat polymorphonuclear leukocytes.

1987 • 25 citations

Effects of starvation and different culture conditions on the phospholipid content of isolated pancreatic islets

1984 • 22 citations

Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes.

1991 • 21 citations

Resolution of radiolabeled molecular species of phospholipid in human platelets: Effect of thrombin

1987 • 15 citations

Quantification of distinct molecular species of the 2-lyso metabolite of platelet-activating factor by gas chromatography—negative-ion chemical ionization mass spectrometry

1992 • 5 citations