Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death

Social controls on cell survival and cell death

1992 • 2,641 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

1993 • 694 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product

1995 • 604 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

The role of proteases during apoptosis

1996 • 558 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

1992 • 336 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices

1990 • 326 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

1997 • 284 citations

Glutamate triggers internucleosomal DNA cleavage in neuronal cells

1991 • 276 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

1996 • 262 citations

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

1995 • 258 citations

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

1995 • 258 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity

1995 • 226 citations

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

1995 • 222 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

1995 • 202 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

Reduction of delayed neuronal death by inhibition of protein synthesis

1990 • 190 citations

Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.

1996 • 185 citations

The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation

1993 • 181 citations

Slowly triggered excitotoxicity occurs by necrosis in cortical cultures

1997 • 175 citations

Neuronal Apoptosis: Current Understanding of Molecular Mechanisms and Potential Role in Ischemic Brain Injury

1995 • 168 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

Aspartate-Based Inhibitor of Interleukin-1β-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells

1995 • 151 citations

Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

1996 • 149 citations

Internucleosomal DNA Cleavage Involved in Ischemia-Induced Neuronal Death

1993 • 139 citations

Evidence for hypoxia‐induced, programmed cell death of cultured neurons

1994 • 120 citations

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

1991 • 110 citations

An in situ hybridization study on interleukin-1β mRNA induced by transient forebrain ischemia in the rat brain

1994 • 109 citations

Possible involvement of interleukin-1 in ischemic brain edema formation

1992 • 108 citations

Interleukin-1β Enhances Survival and Interleukin-6 Protects against MPP+ Neurotoxicity in Cultures of Fetal Rat Dopaminergic Neurons

1995 • 106 citations

INTERLEUKIN-1β STIMULATES SOMATOSTATIN BIOSYNTHESIS IN PRIMARY CULTURES OF FETAL RAT BRAIN

1989 • 106 citations

Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells.

1995 • 98 citations

Multiple Proteases Are Involved in Thymocyte Apoptosis

1995 • 82 citations

Kainate induces apoptosis in neurons

1996 • 67 citations

Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death

1995 • 58 citations

Ultrastructure of excitotoxic neuronal death in murine cortical culture

1995 • 55 citations

Delayed application of aurintricarboxylic acid reduces glutamate‐induced cortical neuronal injury

1994 • 54 citations

NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells

1997 • 48 citations

Differential effects of interleukin‐1β and interleukin‐2 on glia and hippocampal neurons in culture

1995 • 47 citations

Induction of Neuronal Apoptosis by Excitotoxins Associated with Long‐Lasting Increase of 12‐O‐Tetradecanoylphorbol 13‐Acetate‐Responsive Element‐Binding Activity

1995 • 43 citations

Interleukin-1β increases basic fibroblast growth factor mRNA expression in adult rat brain and organotypic hippocampal cultures

1994 • 42 citations