Differential effects of interleukin‐1β and interleukin‐2 on glia and hippocampal neurons in culture

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

1988 • 557 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Ameboid microglia as effectors of inflammation in the central nervous system

1987 • 477 citations

The Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

1987 • 456 citations

Visualization and characterization of interleukin 1 receptors in brain.

1987 • 451 citations

Interleukin-1 is an astroglial growth factor in the developing brain

1988 • 442 citations

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1992 • 396 citations

Interactions between the Neuroendocrine and Immune Systems: Common Hormones and Receptors

1987 • 371 citations

Immunoreactive interleukin-1β localization in the rat forebrain

1990 • 343 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Stimulation of oligodendroglial proliferation and maturation by interleukin-2

1986 • 251 citations

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

1988 • 248 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

1990 • 238 citations

Production of hemopoietic colony-stimulating factors by astrocytes.

1990 • 237 citations

Peptides released by ameboid microglia regulate astroglial proliferation.

1985 • 209 citations

Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors

1992 • 192 citations

Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo

1990 • 184 citations

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

1989 • 179 citations

The Immune Logical Brain

1987 • 175 citations

Involvement of cytokines in acute neurodegeneration in the CNS

1993 • 169 citations

Phase I evaluation of recombinant interleukin-2 in patients with advanced malignant disease.

1986 • 144 citations

Immune system associated antigens expressed by cells of the human central nervous system

1988 • 132 citations

Neuromodulative actions of cytokines.

1990 • 116 citations

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

1991 • 111 citations

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors

1994 • 111 citations

A role for interleukin-2 in the regulation of striatal dopaminergic function

1992 • 107 citations

Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2

1993 • 107 citations

Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro.

1986 • 103 citations

Interleukin-1 stimulates the beta-amyloid precursor protein promoter

1990 • 95 citations

Central nervous system toxicity of interferons and other cytokines.

1988 • 81 citations

In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain

1989 • 79 citations

In situ hybridization histochemistry localization of interleukin-3 mRNA in mouse brain

1989 • 78 citations

Toxicity of human recombinant interleukin-2 in rats. Pathologic changes are characterized by marked lymphocytic and eosinophilic proliferation and multisystem involvement.

1989 • 68 citations

Interleukin‐2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth

1990 • 65 citations

Interleukin-2-like activity in injured rat brain

1987 • 64 citations

Interleukin‐2 Effects in the Central Nervous Systema

1990 • 53 citations

Potential Neurotrophic Factors in the Mammalian Central Nervous System: Functional Significance in the Developing and Aging Brain

1990 • 48 citations

Soluble interleukin‐2 receptors in cerebrospinal fluid from individuals with various neurological disorders

1990 • 44 citations

Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus

1993 • 43 citations

Focusing on IL1-promotion of β-amyloid precursor protein synthesis as an early event in Alzheimer's disease

1989 • 36 citations

Immune actions in the nervous system: A brief review with special emphasis on Aalzheimer's disease

1988 • 27 citations

Interleukin‐2 inhibition of oligodendrocyte progenitor cell proliferation depends on expression of the TAC receptor

1987 • 24 citations

Immunoregulatory Factors Secreted by Astrocytes and Glioblastoma Cells

1987 • 24 citations

Interleukin 1 receptors and biological responses.

1990 • 15 citations

Expression of HLA-DR and interleukin-2 receptor on reactive microglia in senile dementia of the alzheimer's type

1987 • 9 citations