The aromatic binding site for tetraethylammonium ion on potassium channels

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

1989 • 765 citations

Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K ⁺ Channel

1991 • 634 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K ⁺ Channels

1990 • 569 citations

The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion

1967 • 490 citations

Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes

1990 • 461 citations

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning

1989 • 457 citations

Anomalous Rectification in the Squid Giant Axon Injected with Tetraethylammonium Chloride

1965 • 439 citations

Ion-solvent molecule interactions in the gas phase. The potassium ion and benzene

1981 • 382 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

The Inner Quaternary Ammonium Ion Receptor in Potassium Channels of the Node of Ranvier

1972 • 302 citations

Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cells

1989 • 189 citations

Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes

1981 • 177 citations

Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel.

1982 • 156 citations

Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features

1988 • 155 citations

Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.

1991 • 146 citations

Probing a Ca2+-activated K+ channel with quaternary ammonium ions

1988 • 139 citations

Molecular recognition in aqueous media: donor-acceptor and ion-dipole interactions produce tight binding for highly soluble guests

1988 • 121 citations

Ion-dipole effect as a force for molecular recognition in organic media

1988 • 58 citations