A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

1982 • 842 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

MYELINATION IN RAT BRAIN: CHANGES IN MYELIN COMPOSITION DURING BRAIN MATURATION¹

1973 • 655 citations

Evidence for saltatory conduction in peripheral myelinated nerve fibres

1949 • 617 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Heterologous introns can enhance expression of transgenes in mice.

1991 • 489 citations

Synthesis and incorporation of myelin polypeptides into CNS myelin.

1982 • 422 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype

1987 • 389 citations

Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase

1987 • 375 citations

Basolateral sorting of LDL receptor in MDCK cells: The cytoplasmic domain contains two tyrosine-dependent targeting determinants

1992 • 366 citations

A generic intron increases gene expression in transgenic mice.

1991 • 351 citations

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein

1985 • 345 citations

Maturation of human white matter myelin. Fractionation of the myelin membrane proteins

1968 • 343 citations

Emergence of three myelin proteins in oligodendrocytes cultured without neurons.

1986 • 333 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture

1987 • 317 citations

Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.

1987 • 300 citations

The first twelve amino acids (less than half of the pre-sequence) of an imported mitochondrial protein can direct mouse cytosolic dihydrofolate reductase into the yeast mitochondrial matrix.

1985 • 279 citations

Molecular Biology of Myelin Proteins from the Central Nervous System

1988 • 238 citations

A Prospectus for Multispectral-Multiplex DNA Sequencing

1989 • 233 citations

Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid thioester-linked cysteine residues and implications for the membrane topology of PLP

1992 • 227 citations

Cellular and molecular aspects of myelin protein gene expression

1988 • 224 citations

Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders

1985 • 213 citations

Tissue-specific control elements of the Thy-1 gene.

1990 • 207 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

Regulatory elements in the first intron contribute to transcriptional control of the human alpha 1(I) collagen gene.

1987 • 191 citations

Morphology of Myelin and Myelination

1984 • 189 citations

Individual exons encode the integral membrane domains of human myelin proteolipid protein.

1986 • 177 citations

A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43

1989 • 176 citations

DM‐20 mRNA Is Expressed During the Embryonic Development of the Nervous System of the Mouse

1992 • 173 citations

Identification of a phenotype-specific enhancer in the first intron of the rat collagen II gene.

1987 • 163 citations

Myelin‐specific proteolipid protein is expressed in myelinating schwann cells but is not incorporated into myelin sheaths

1987 • 154 citations

The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly

1992 • 149 citations

Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expression.

1992 • 144 citations

Selective Expression of DM‐20, an Alternatively Spliced Myelin Proteolipid Protein Gene Product, in Developing Nervous System and in Nonglial Cells

1992 • 141 citations

Structure and expression of the mouse myelin proteolipid protein gene

1987 • 130 citations

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene.

1989 • 124 citations

A Generic Intron Increases Gene Expression in Transgenic Mice

1991 • 114 citations

The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum.

1992 • 113 citations

Characterization of tissue-specific enhancer elements in the second intron of the human apolipoprotein B gene.

1991 • 98 citations

Expression of myelin protein genes in Schwann cells

1989 • 96 citations

Quantitative analysis of myelin protein gene expression during development in the rat sciatic nerve

1990 • 91 citations

Tissue‐specific expression of p53 in transgenic mice is regulated by intron sequences

1991 • 84 citations

DM20 mRNA splice product of the myelin proteolipid protein gene is expressed in the murine heart

1992 • 82 citations

Myelin Proteolipid Protein Gene Expression in Jimpy and Jimpy^msdMice

1988 • 82 citations

Characterization of Myelin Proteolipid mRNAs in Normal and Jimpy Mice

1986 • 80 citations

Expression of the human PDGF-B gene is regulated by both positively and negatively acting cell type-specific regulatory elements located in the first intron.

1991 • 79 citations

Developmental Expression of Proteolipid Protein and DM20 mRNAs and Proteins in the Rat Brain

1990 • 76 citations

The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome

1986 • 74 citations

Silencing of the Expression of the Immunoglobulin Kappa Gene in Non-B Cells

1991 • 72 citations

Structure and expression of proteolipid protein in the peripheral nervous system

1992 • 70 citations

Targeting of neuromodulin (GAP-43) fusion proteins to growth cones in cultured rat embryonic neurons

1991 • 70 citations

Structure and Function of Myelin Protein Genes

1991 • 68 citations

Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice

1988 • 67 citations

β-galactosidase expressing recombinant pseudorabies virus for light and electron microscopic study of transneuronally labeled CNS neurons

1991 • 64 citations

Expression of myelin proteins in the developing human spinal cord: Cloning and sequencing of human proteolipid protein cDNA

1987 • 64 citations

Protein kinase C activity modulates myelin gene expression in enriched oligodendrocytes

1993 • 64 citations

Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor

1991 • 53 citations

Intragenic Sequences Affect the Expression of the Gene Encoding Glial Fibrillary Acidic Protein

1991 • 49 citations

Proteolipid DM-20 predominates over PLP in peripheral nervous system

1991 • 49 citations

Identification of cis-regulatory elements in the myelin proteolipid protein (PLP) gene.

1992 • 48 citations

Mutations in the Myelin Proteolipid Protein Gene Alter Oligodendrocyte Gene Expression in Jimpy and Jimpy^msd Mice

1991 • 46 citations

Developmental Study of Proteolipids in Bovine Brain: A Novel Proteolipid and DM‐20 Appear Before Proteolipid Protein (PLP) During Myelination

1990 • 44 citations

Human myelin DM-20 proteolipid protein deletion defined by cDNA sequence

1987 • 42 citations

The DM20 Protein of Myelin: Intracellular and Surface Expression Patterns in Transfectants

1992 • 31 citations

Proteolipid protein and DM-20 are synthesized by Schwann cells, present in myelin membrane, but they are not fatty acylated

1991 • 27 citations

Characterization of a cis-acting element required for efficient transcriptional activation of the collagen IV enhancer.

1991 • 27 citations

Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

1989 • 24 citations

Levels of Proteolipid Protein mRNAs in Peripheral Nerve Are Not Under Stringent Axonal Control

1991 • 23 citations

Regulation of rodent myelin proteolipid protein gene expression

1992 • 20 citations

Reliable Transient Promoter Assay Using Fluorescein-di-β-D-galactopyranoside Substrate

1990 • 15 citations

Recent Advances in Studies on Genes for Myelin Proteins

1991 • 11 citations

β-Globin Enhancers Target Expression of a Heterologous Gene to Erythroid Tissues of Transgenic Mice

1989 • 4 citations