Molecular Biology of Myelin Proteins from the Central Nervous System

Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1

1984 • 723 citations

Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System

1964 • 607 citations

The J1 glycoprotein—a novel nervous system cell adhesion molecule of the L2/HNK-1 family

1985 • 590 citations

Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve.

1986 • 482 citations

THE REGIONAL AND SUBCELLULAR DISTRIBUTION OF 2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE IN THE CENTRAL NERVOUS SYSTEM

1967 • 458 citations

Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1

1983 • 431 citations

Synthesis and incorporation of myelin polypeptides into CNS myelin.

1982 • 422 citations

Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype

1987 • 389 citations

Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice

1983 • 382 citations

The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily

1987 • 370 citations

Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.

1979 • 360 citations

Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein

1985 • 345 citations

Maturation of human white matter myelin. Fractionation of the myelin membrane proteins

1968 • 343 citations

Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice

1985 • 331 citations

Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing.

1987 • 320 citations

Alternative splicing accounts for the four forms of myelin basic protein

1985 • 306 citations

QUAKING MOUSE: ISOLATION AND CHARACTERIZATION OF MYELIN PROTEIN

1971 • 305 citations

Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin.

1987 • 300 citations

Molecular cloning and primary structure of myelin-associated glycoprotein.

1987 • 284 citations

PATHOGENESIS OF SUBACUTE COMBINED DEGENERATION: A RESULT OF METHYL GROUP DEFICIENCY

1981 • 248 citations

Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons

1985 • 234 citations

Cellular and molecular aspects of myelin protein gene expression

1988 • 224 citations

Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.

1986 • 219 citations

Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit

1986 • 218 citations

Studies on 2′,3′-cyclic nucleotide-3′-phosphohydrolase from brain

1969 • 216 citations

Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders

1985 • 213 citations

Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin.

1982 • 207 citations

Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin

1987 • 194 citations

CHANGES IN THE PROTEIN COMPOSITION OF MOUSE BRAIN MYELIN DURING DEVELOPMENT

1972 • 188 citations

Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides

1983 • 188 citations

Shiverer: an autosomal recessive mutant mouse with myelin deficiency

1981 • 187 citations

2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE IN BRAINS OF MUTANT MICE WITH DEFICIENT MYELINATION

1970 • 185 citations

Individual exons encode the integral membrane domains of human myelin proteolipid protein.

1986 • 177 citations

Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.

1987 • 174 citations

Myelin-Associated Glycoprotein in Development and Disease

1983 • 172 citations

A Single Nucleotide Difference in the Gene for Myelin Proteolipid Protein Defines the Jimpy Mutation in Mouse

1987 • 167 citations

Identification of three forms of human myelin basic protein by cDNA cloning.

1986 • 161 citations

The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice

1986 • 154 citations

2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE IN THE DEVELOPING CHICK BRAIN AND SPINAL CORD

1968 • 153 citations

ACCUMULATION OF THE FOUR MYELIN BASIC PROTEINS IN MOUSE BRAIN DURING DEVELOPMENT¹

1978 • 149 citations

Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation.

1986 • 143 citations

Developmental regulation of myelin basic protein expression in mouse brain

1983 • 138 citations

Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.

1987 • 132 citations

A NEW PROTEOLIPID FRACTION OF THE NERVOUS. SYSTEM *–I.

1966 • 131 citations

Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase: mRNAs with different 5' ends encode the same set of proteins in nervous and lymphoid tissues

1987 • 130 citations

Structure and expression of the mouse myelin proteolipid protein gene

1987 • 130 citations

ACTIVITY OF 2′,3′‐CYCLIC‐NUCLEOTIDE 3′‐PHOSPHODIESTERASE IN REGIONS OF RAT BRAIN DURING DEVELOPMENT: QUANTITATIVE RELATIONSHIP TO MYELIN BASIC PROTEIN

1978 • 126 citations

Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone.

1984 • 118 citations

Quaking mouse: ultrastructural evidence for arrest of myelinogenesis

1971 • 115 citations

Developmental Expression of the Myelin Proteolipid Protein and Basic Protein mRNAs in Normal and Dysmyelinating Mutant Mice

1987 • 112 citations

Two developmentally regulated messenger RNAs differing in their coding region may exist for the myelin-associated glycoprotein.

1984 • 105 citations

Myelinogenesis in optic nerve. A morphological, autoradiographic, and biochemical analysis.

1977 • 103 citations

An AG→GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exon

1987 • 95 citations

Expression of Myelin Proteolipid Protein and Basic Protein in Normal and Dysmyelinating Mutant Mice

1986 • 93 citations

Ontogenetic study of a myelin-derived fraction with 2′:3′-cyclic nucleotide 3′-phosphodydrolase activity higher than that of myelin

1975 • 91 citations

Molecular Genetic Analysis of Myelin‐Deficient Mice: Shiverer Mutant Mice Show Deletion in Gene(s) Coding for Myelin Basic Protein

1985 • 89 citations

Gel electrophoresis studies of bovine brain white matter proteolipid and myelin proteins

1974 • 89 citations

2′, 3′-Cyclic nucleotide 3′-phosphohydrolase in the brain of the “Jimpy” mouse, a mutant with deficient myelination

1969 • 89 citations

Immunology: The growing immunoglobulin gene superfamily

1986 • 87 citations

Biochemical maturation of the central nervous system

1969 • 87 citations

A neurological mutation (msd) of the mouse causing a deficiency of myelin synthesis

1970 • 87 citations

Oligodendroglial Expression and Deposition of Four Major Myelin Constituents in the Myelin Sheath during Development

1986 • 85 citations

Myelin Proteolipid Protein Gene Expression in Jimpy and Jimpy^msdMice

1988 • 82 citations

Brain proteolipids in neurological mutant mice

1973 • 82 citations

Synthesis of myelin basic proteins in the developing mouse brain

1978 • 81 citations

Characterization of Myelin Proteolipid mRNAs in Normal and Jimpy Mice

1986 • 80 citations

Purification and partial characterization of the myelin-associated glycoprotein from adult rat brain

1983 • 79 citations

Biochemical maturation of the central nervous system. II. Protein and proteolytic enzyme changes

1970 • 75 citations

The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome

1986 • 74 citations

Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning

1987 • 73 citations

Myelin proteolipid protein (PLP and DM-20) transcripts are deleted in jimpy mutant mice.

1986 • 71 citations

Characterization of myelin proteolipid mRNAs in normal and jimpy mice.

1986 • 69 citations

Regional distribution of myelin basic protein in the central nervous system of quaking, jimpy, and normal mice during development and aging

1981 • 66 citations

Expression of myelin proteins in the developing human spinal cord: Cloning and sequencing of human proteolipid protein cDNA

1987 • 64 citations

Study of the expression of myelin proteolipid protein (lipophilin) using a cloned complementary DNA

1985 • 63 citations

Myelin‐Associated Glycoprotein: Electron Microscopic Immunocytochemical Localization in Compact Developing and Adult Central Nervous System Myelin

1983 • 62 citations

Myelin Basic Protein Deposition in the Optic and Sciatic Nerves of Dysmyelinating Mutants Quaking, Jimpy, Trembler, MLD, and Shiverer During Development

1983 • 62 citations

The Effect of the Shiverer Mutation on Myelin Basic Protein Expression in Homozygous and Heterozygous Mouse Brain

1983 • 61 citations

Density Profile and Basic Protein Measurements in the Myelin Range of Particulate Material from Normal Developing Mouse Brain and from Neurological Mutants (Jimpy; Quaking; Trembler; Shiverer and its mid Allele) Obtained by Zonal Centrifugation

1980 • 61 citations

Effect of the Jimpy Mutation on Expression of Myelin Proteins in Heterozygous and Hemizygous Mouse Brain

1984 • 61 citations

Myelin‐Deficient Rat: Analysis of Myelin Proteins

1986 • 58 citations

Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid

1985 • 58 citations

Abnormal Expression of the Myelin‐Associated Glycoprotein in the Central Nervous System of Dysmyelinating Mutant Mice

1985 • 57 citations

External labeling of galactose in surface membrane glycoproteins of the intact myelin sheath.

1976 • 56 citations

Myelin deficient, a new neurological mutant in the mouse

1977 • 56 citations

Cell‐Free Synthesis of Myelin Basic Proteins in Normal and Dysmyelinating Mutant Mice

1984 • 55 citations

The myelin deficit in quaking mice

1974 • 54 citations

In Vitro Synthesis of the Four Mouse Myelin Basic Proteins: Evidence for the Lack of a Metabolic Relationship

1982 • 53 citations

Appearance of Myelin Proteins during Development in the Chick Central Nervous System

1985 • 49 citations

Inefficient Transcription of the Myelin Basic Protein Gene Possibly Causes Hypomyelination in Myelin‐Deficient Mutant Mice

1987 • 48 citations

Localization of the human myelin basic protein gene <i>(MBP)</i> to region 18q22→qter by in situ hybridization

1985 • 48 citations

Shiverer gene maps near the distal end of chromosome 18 in the house mouse

1985 • 48 citations

Jimpy Mice: Quantitation of Myelin‐Associated Glycoprotein and Other Proteins

1986 • 48 citations

Isolation and characterization of a cDNA coding for a novel human 17.3k myelin basic protein (MBP) variant

1986 • 47 citations

A specific immunological probe for the major myelin proteolipid

1986 • 47 citations

Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungoin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice

1986 • 45 citations

Use of chimeras to transmit lethal genes in the mouse and to demonstrate allelism of the two X‐linked male lethal genes jp and msd

1973 • 44 citations

Localization of Glycoconjugates Recognized by the HNK-1 Antibody in Mouse and Chick Embryos during Early Neural Development

1987 • 43 citations

Isolation of 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase from Human Brain

1980 • 43 citations

Glycoproteins in Myelin and Myelin-Related Membranes

1979 • 42 citations

cDNA cloning and amino acid sequence of bovine brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

1987 • 42 citations

Expression of Myelin Basic Protein Genes in Several Dysmyelinating Mouse Mutants During Early Postnatal Brain Development

1985 • 41 citations

A developmental study of the relationship between the protein components of rat CNS myelin.

1973 • 41 citations

Small basic proteins of myelin from central and peripheral nervous systems are encoded by the same gene.

1986 • 40 citations

Cycloleucine-induced vacuolation of myelin is associated with inhibition of protein methylation

1981 • 39 citations

PROTEOLIPIDS IN THE DEVELOPING BRAINS OF NORMAL MICE AND MYELIN DEFICIENT MUTANTS¹

1974 • 39 citations

Synthesis of the myelin proteolipid protein in the developing mouse brain

1980 • 37 citations

The differentiation of synthesis from incorporation of basic protein in quaking mutant mouse myelin

1977 • 37 citations

Myelin-associated glycoprotein and myelinating Schwann cell-axon interaction in chronic B,B'-iminodipropionitrile neuropathy.

1984 • 36 citations

Evidence for defective incorporation of proteins in myelin of the quaking mutant mouse

1977 • 35 citations

Myelin-Associated Enzymes

1983 • 35 citations

Hypomyelinated mutant mice. II. Myelination in vitro

1980 • 33 citations

Myelin basic protein gene expression in quaking, jimpy, and myelin synthesis-deficient mice

1984 • 32 citations

Electroblot Analysis of Rat Myelin Proteolipid Protein and Basic Protein during Development

1983 • 31 citations

Developmental change in a myelin-associated glycoprotein: a comparative study in rodents

1974 • 31 citations

Myelin: Chemistry and biology

1981 • 31 citations

Factors affecting the electrophoretic analysis of myelin proteins: Application to changes occurring during brain development

1977 • 30 citations

Myelin instability and oligodendrocyte metabolism in myelin-deficient mutant mice.

1986 • 30 citations

Mice heterozygous for the mld mutation have intermediate levels of myelin basic protein mRNA and its translation products

1986 • 29 citations

Hypomyelinated mutant mice. V. Relationship between jp and jpmsd re-examined on identical genetic backgrounds

1983 • 29 citations

The genes for myelin

1987 • 29 citations

Lipophilin (PLP) Gene in X‐linked myelin disorders

1986 • 29 citations

Biochemical and immunohistochemical studies on dysmyelination of quaking mutant mice in vivo and in vitro

1979 • 28 citations

Assignment of the myelin basic protein gene to human chromosome 18q22-qter

1987 • 26 citations

Translational regulation of myelin basic protein synthesis

1987 • 26 citations

Purification and characterization of minor brain proteolipids: use of fast atom bombardment — mass spectrometry for peptide sequencing

1986 • 25 citations

PURIFICATION OF 2′,3′‐CYCLIC NUCLEOTIDE 3′‐PHOSPHOHYDROLASE FROM BOVINE BRAIN BY IMMUNOAFFINITY CHROMATOGRAPHY: FURTHER BIOCHEMICAL CHARACTERIZATION OF THE PROTEIN

1979 • 25 citations

Developmental changes in the basic proteins of normal and jimpy mouse brain

1972 • 25 citations

MYELIN PROTEOLIPID PROTEIN

1988 • 24 citations

PROTEOLIPID PROTEIN: SYNTHESIS AND ASSEMBLY INTO QUAKING MOUSE MYELIN

1979 • 23 citations

Arylsulphatase a and 2',3'-cyclic nucleotide 3'-phosphohydrolase activities in the brains of myelin deficient mutant mice

1976 • 22 citations

Myelin‐Associated Glycoprotein in the Central and Peripheral Nervous System of Quaking Mice

1987 • 22 citations

Biosynthesis and insertion of Wolfgram protein into optic nerve membranes

1985 • 20 citations

In vitro myelin basic protein synthesis in the PNS and CNS of myelin deficient (mld) mutant mice

1983 • 19 citations

A regional study of developing rat brain: The accumulation and distribution of proteolipid proteins

1976 • 16 citations

Immunohistochemical Localization of 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase and Myelin Basic Protein in the Central Nervous System of the Jimpy and the Normal Mouse

1985 • 15 citations

Expression of myelin protein genes in the developing brain.

1987 • 14 citations

Protein Metabolism of Oligodendroglial Cells In Vivo

1984 • 14 citations

Cell free synthesis of rat brain myelin proteolipids and their identification by immunoprecipitation

1983 • 13 citations

Hypomyelinated mutant mice IV: Peripheral myelin injpmsd

1981 • 11 citations

The quaking mouse: Regional variations in the content and protein composition of myelin isolated from the central nervous system

1979 • 11 citations

Immunochemical evidence of phosphorylation of a new 23K basic protein in rat brain myelin

1986 • 10 citations

Developmental expression of myelin basic protein mRNA in a hypermyelinating mouse

1986 • 9 citations

Allelism of two myelin deficiency mutations in the mouse

1981 • 9 citations

Characterization of a novel monoclonal anti-myelin basic protein antibody: use in immunoblotting and immunohistochemical studies

1987 • 8 citations