Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin‐induced mitogenesis in smooth muscle cells

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor.

1991 • 722 citations

Role of basic fibroblast growth factor in vascular lesion formation.

1991 • 521 citations

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.

1993 • 506 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

1992 • 461 citations

Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin.

1984 • 442 citations

Use of the polymerase chain reaction in the quantitation of MDR-1 gene expression

1990 • 427 citations

Thrombin receptor expression in normal and atherosclerotic human arteries.

1992 • 318 citations

Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

1986 • 310 citations

Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries.

1990 • 282 citations

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.

1988 • 274 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Biological and biochemical properties of fibroblast growth factors. Implications for the pathogenesis of atherosclerosis.

1989 • 228 citations

Molecular cloning of the rat vascular smooth muscle thrombin receptor. Evidence for in vitro regulation by basic fibroblast growth factor.

1992 • 165 citations

Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.

1986 • 162 citations

Quantification of mRNA by non-radioactive RT-PCR and CCD imaging system

1992 • 156 citations

Characterization of thrombin receptor expression during vascular lesion formation.

1994 • 136 citations

von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively

1987 • 126 citations

Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin.

1985 • 113 citations

The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor.

1993 • 111 citations

Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells.

1992 • 110 citations

Shear stress modulates the proliferation rate, protein synthesis, and mitogenic activity of arterial smooth muscle cells.

1993 • 106 citations

Basic fibroblast growth factor: expression in cultured bovine vascular smooth muscle cells.

1988 • 106 citations

Deendothelialization in vivo initiates a thrombogenic reaction at the rabbit aorta surface. Correlation of uptake of fibrinogen and antithrombin III with thrombin generation by the exposed subendothelium.

1989 • 102 citations

Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells.

1992 • 89 citations

Thrombin as a Multifunctional Protein: Induction of Cell Adhesion and Proliferation

1992 • 88 citations

Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist.

1996 • 87 citations

Thrombin Enhances T Cell Proliferative Responses and Cytokine Production

1993 • 77 citations

The effects of thrombin on bovine aortic endothelial and smooth muscle cells

1990 • 76 citations

G-protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells.

1996 • 74 citations

Induction of vascular smooth muscle cell growth by selective activation of the thrombin receptor Effect of heparin

1992 • 73 citations

Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.

1997 • 61 citations

Thrombin Generation following Arterial Injury Is a Critical Initiating Event in the Pathogenesis of the Proliferative Stages of the Atherosclerotic Process

1994 • 50 citations

Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA

1993 • 48 citations

Thrombin Induces Production of Growth Factors from Aortic Smooth Muscle Cells

1999 • 40 citations

Measurement of Blood‐Brain Barrier GLUT1 Glucose Transporter and Actin mRNA by a Quantitative Polymerase Chain Reaction Assay

1994 • 33 citations

Thrombin binds to murine bone marrow-derived macrophages and enhances colony-stimulating factor-1-driven mitogenesis.

1990 • 21 citations

The effects of thrombin on bovine aortic endothelial and smooth muscle cells

1990 • 7 citations