Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.

1986 • 1,644 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.

1993 • 506 citations

PDGF ligand and receptor gene expression during repair of arterial injury.

1990 • 431 citations

Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits.

1991 • 223 citations

Culture of quiescent arterial smooth muscle cells in a defined serum‐free medium

1983 • 220 citations

Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta.

1990 • 214 citations

Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta.

1992 • 188 citations

Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.

1992 • 178 citations

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

1992 • 146 citations

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.

1991 • 121 citations

Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells.

1992 • 110 citations

Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells.

1992 • 89 citations

Thrombin‐induced proliferation and expression of platelet‐derived growth factor‐A chain gene in human vascular smooth muscle cells

1992 • 73 citations

The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation.

1992 • 38 citations

Specific growth stimulation of cultured smooth muscle cells from spontaneously hypertensive rats by platelet-derived growth factor A-chain homodimer.

1990 • 31 citations

Dissociation between activation of growth-related genes and mitogenic responses of neonatal vascular smooth muscle cells

1991 • 16 citations