Back to search

The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence

Data up to Jan 2025

Published2005
Citations117
References356

Total Citations Per Year

Abstract

References (356)

Diagnostic and Statistical Manual of Mental Disorders.

2000 • 19,705 citations

The Brief Symptom Inventory: an introductory report

1983 • 6,443 citations

Actual Causes of Death in the United States, 2000

2004 • 5,189 citations

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Drug Abuse: Hedonic Homeostatic Dysregulation

1997 • 2,472 citations

Drug Dependence, a Chronic Medical Illness

2000 • 2,396 citations

A Specific Laboratory Test for the Diagnosis of Melancholia

1981 • 2,238 citations

Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study

1983 • 1,954 citations

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

1997 • 1,773 citations

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

2000 • 1,655 citations

Signs and Symptoms of Tobacco Withdrawal

1986 • 1,623 citations

The reinstatement model of drug relapse: history, methodology and major findings

2002 • 1,586 citations

Cigarette Smoking Among Adults--United States, 2003

2005 • 1,531 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Incentive‐sensitization and addiction

2001 • 1,397 citations

Shape of the relapse curve and long‐term abstinence among untreated smokers

2003 • 1,364 citations

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

1990 • 1,362 citations

Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

2000 • 1,334 citations

The psychology and neurobiology of addiction: an incentive–sensitization view

2000 • 1,288 citations

Addiction and the brain: The neurobiology of compulsion and its persistence

2001 • 1,284 citations

CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors

2004 • 1,235 citations

Alcohol dependence: provisional description of a clinical syndrome.

1976 • 1,167 citations

Prevalence of smoking among psychiatric outpatients

1986 • 1,059 citations

Smoking, stress, and negative affect: Correlation, causation, and context across stages of smoking.

2003 • 1,054 citations

Post-Traumatic Stress Disorder

2002 • 1,031 citations

Cannabis use and mental health in young people: cohort study

2002 • 982 citations

The psychology and neurobiology of addiction: an incentive–sensitization view

2000 • 965 citations

Expression cloning of a human corticotropin-releasing-factor receptor.

1993 • 923 citations

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

1998 • 919 citations

Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression

1995 • 917 citations

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

2001 • 911 citations

Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development

1998 • 883 citations

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

2001 • 877 citations

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

2000 • 836 citations

Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

1995 • 836 citations

Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety

2003 • 836 citations

Smoking Cessation and Severity of Weight Gain in a National Cohort

1991 • 825 citations

Cognitive Functioning of Long-term Heavy Cannabis Users Seeking Treatment

2002 • 785 citations

The Dexamethasone Suppression Test for Melancholia

1982 • 774 citations

Pharmacological Management of Alcohol Withdrawal

1997 • 753 citations

Corticotropin releasing factor produces behavioural activation in rats

1982 • 752 citations

Neurobiological Similarities in Depression and Drug Dependence: A Self-Medication Hypothesis

1998 • 752 citations

Alcoholism: Allostasis and Beyond

2003 • 738 citations

Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder

1997 • 709 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

2000 • 698 citations

Dramatic decreases in brain reward function during nicotine withdrawal

1998 • 676 citations

The role of stress in drug self-administration

1998 • 670 citations

The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders

1994 • 663 citations

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

2001 • 647 citations

Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis

1996 • 637 citations

Psychomotor stimulant addiction: a neural systems perspective.

2002 • 635 citations

Neuroendocrine Regulation in Depression

1976 • 628 citations

Corticotropin-releasing factor, norepinephrine, and stress

1999 • 623 citations

Dose-related neurocognitive effects of marijuana use

2002 • 597 citations

Neurobiological mechanisms in the transition from drug use to drug dependence

2003 • 575 citations

Psychomotor Stimulant Addiction: A Neural Systems Perspective

2002 • 573 citations

Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis

1995 • 568 citations

Interchangeability of Stress and Amphetamine in Sensitization

1980 • 565 citations

Prevalence of Marijuana Use Disorders in the United States

2004 • 534 citations

The Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry

1985 • 530 citations

College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement

2003 • 527 citations

Serial CSF Corticotropin-Releasing Hormone Levels and Adrenocortical Activity in Combat Veterans With Posttraumatic Stress Disorder

1999 • 526 citations

Impaired auditory recognition of fear and anger following bilateral amygdala lesions

1997 • 523 citations

Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder

1993 • 515 citations

Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary.

1994 • 514 citations

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

2002 • 513 citations

Smoking cessation and weight gain

2004 • 513 citations

Association Between Cigarette Smoking and Anxiety Disorders During Adolescence and Early Adulthood

2000 • 501 citations

The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders

1999 • 498 citations

The Influence of Smoking Cessation on the Prevalence of Overweight in the United States

1995 • 495 citations

Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal

1997 • 494 citations

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

2000 • 490 citations

Psychiatric implications of basic and clinical studies with corticotropin-releasing factor

1984 • 486 citations

Role of Corticotropin-Releasing Factor in Drug Addiction

2011 • 477 citations

Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study

1985 • 474 citations

Early onset cannabis use and psychosocial adjustment in young adults

1997 • 473 citations

Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior

1994 • 462 citations

THALIDOMIDE AND LIMB DEFORMITIES

1962 • 461 citations

Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats

1988 • 455 citations

Dose-Response Changes in Plasma Cortisol and Lymphocyte Glucocorticoid Receptors Following Dexamethasone Administration in Combat Veterans With and Without Posttraumatic Stress Disorder

1995 • 452 citations

CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.

1995 • 444 citations

Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal

1997 • 436 citations

The time course and significance of cannabis withdrawal.

2003 • 429 citations

Negative Affect and Smoking Lapses: A Prospective Analysis.

2004 • 421 citations

Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor.

1993 • 414 citations

Compulsive Drug‐Seeking Behavior and Relapse

2001 • 412 citations

Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

1993 • 411 citations

Modulation of Learning and Anxiety by Corticotropin-Releasing Factor (CRF) and Stress: Differential Roles of CRF Receptors 1 and 2

1999 • 405 citations

Corticotrophin-releasing factor receptors: from molecular biology to drug design

1996 • 399 citations

Neurobiological evidence for hedonic allostasis associated with escalating cocaine use

2002 • 387 citations

Increased Ethanol Self‐Administration and Anxiety‐Like Behavior During Acute Ethanol Withdrawal and Protracted Abstinence: Regulation by Corticotropin‐Releasing Factor

2002 • 386 citations

Smoking cessation and the course of major depression: a follow-up study

2001 • 382 citations

Major depression and cigarette smoking: results of a 21-year longitudinal study

2003 • 380 citations

Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAAReceptor Subunits in Frontal Cortical Brain Region

2004 • 378 citations

Fluoxetine in Depressed Alcoholics

1997 • 375 citations

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

1995 • 374 citations

The impact of stress on addiction

2003 • 359 citations

Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins

1991 • 358 citations

Perceived stress, quitting smoking, and smoking relapse.

1990 • 358 citations

CRF antagonist reverses the “anxiogenic” response to ethanol withdrawal in the rat

1991 • 357 citations

Additive Effect of Stress and Drug Cues on Reinstatement of Ethanol Seeking: Exacerbation by History of Dependence and Role of Concurrent Activation of Corticotropin-Releasing Factor and Opioid Mechanisms

2002 • 357 citations

Urocortin Expression in Rat Brain: Evidence Against a Pervasive Relationship of Urocortin-Containing Projections With Targets Bearing Type 2 CRF Receptors

1999 • 354 citations

Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression

2001 • 353 citations

International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands

2003 • 353 citations

Decreased brain reward produced by ethanol withdrawal.

1995 • 349 citations

Abstinence symptoms following smoked marijuana in humans

1999 • 346 citations

Smoking and Drinking: A Review of the Literature

1990 • 341 citations

CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia

1987 • 339 citations

The DST as a predictor of outcome in depression: a meta-analysis

1993 • 335 citations

The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats

1998 • 326 citations

Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF).

1984 • 322 citations

24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*

1987 • 315 citations

The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats

2000 • 314 citations

Basal cortisol, dexamethasone suppression of cortisol, and MHPG in adolescents after the 1988 earthquake in Armenia

1996 • 313 citations

Corticotropin-Releasing Factor, But Not Corticosterone, Is Involved in Stress-Induced Relapse to Heroin-Seeking in Rats

1997 • 308 citations

Comorbidity between DSM-IV drug use disorders and major depression: Results of a national survey of adults

1995 • 307 citations

The course of anxiety, depression and drinking behaviours after completed detoxification in alcoholics with and without comorbid anxiety and depressive disorders

2001 • 304 citations

Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine

2002 • 304 citations

Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide

1986 • 301 citations

A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats

2001 • 297 citations

Perceived stress, quitting smoking, and smoking relapse.

1990 • 295 citations

Corticotrophin Releasing Factor-Induced Synaptic Plasticity in the Amygdala Translates Stress into Emotional Disorders

2004 • 295 citations

Blockade of Stress-Induced But Not Cocaine-Induced Reinstatement by Infusion of Noradrenergic Antagonists into the Bed Nucleus of the Stria Terminalis or the Central Nucleus of the Amygdala

2002 • 292 citations

The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.

1992 • 288 citations

Potency Trends of Δ9-THC and Other Cannabinoids in Confiscated Marijuana from 1980–1997

2000 • 284 citations

Marijuana and cannabinoid regulation of brain reward circuits

2004 • 282 citations

Complete Amino Acid Sequence of Urotensin I, a Hypotensive and Corticotropin-Releasing Neuropeptide from Catostomus

1982 • 278 citations

Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

1993 • 277 citations

Cigarette Smoking Among Adults—United States, 1994

1996 • 276 citations

Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects

1996 • 275 citations

Neuroadaptive mechanisms of addiction: studies on the extended amygdala

2003 • 275 citations

Cannabinoids: reward, dependence, and underlying neurochemical mechanisms?a review of recent preclinical data

2003 • 275 citations

Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala

1998 • 264 citations

Commitment to abstinence and acute stress in relapse to alcohol, opiates, and nicotine.

1990 • 264 citations

Major depression following smoking cessation

1997 • 263 citations

Stress Responsive Neurohormones in Depression and Anxiety

2003 • 260 citations

Molecular Identification and Analysis of a Novel Human Corticotropin-Releasing Factor (CRF) Receptor: The CRF2γ Receptor

1998 • 258 citations

Abstinence symptoms following oral THC administration to humans

1999 • 256 citations

The 24-Hour Dexamethasone Suppression Test in a Clinical Setting: Relationship to Diagnosis, Symptoms, and Response to Treatment

1979 • 255 citations

Chronic Social Stress Alters Levels of Corticotropin-Releasing Factor and Arginine Vasopressin mRNA in Rat Brain

1997 • 254 citations

Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy

1991 • 253 citations

Methadone‐Related Opioid Agonist Pharmacotherapy for Heroin Addiction: History, Recent Molecular and Neurochemical Research and Future in Mainstream Medicine

2000 • 250 citations

Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment

1996 • 243 citations

Corticotropin-releasing factor has an anxiogenic action in the social interaction test

1987 • 241 citations

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders

2002 • 240 citations

Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides

1995 • 239 citations

Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake

2002 • 239 citations

Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior

1997 • 236 citations

Blockade of Nicotine Self-Administration with Nicotinic Antagonists in Rats

1999 • 235 citations

Effects of Naltrexone and Fluoxetine on Alcohol Self-Administration and Reinstatement of Alcohol Seeking Induced by Priming Injections of Alcohol and Exposure to Stress

1999 • 234 citations

The corticotropin-releasing hormone test in patients with posttraumatic stress disorder

1989 • 233 citations

Cortisol Secretion Rate in Depressive Illness

1964 • 232 citations

Neurobiology of relapse to alcohol in rats

2002 • 230 citations

Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease

1995 • 229 citations

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.

1996 • 228 citations

Stress, Corticotropin‐releasing Factor, and Drug Addiction

1999 • 226 citations

Response to Dexamethasone and Subtype of Depression

1980 • 226 citations

Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers

1982 • 225 citations

The alcohol withdrawal syndrome

1997 • 221 citations

Effects of smoking cessation on weight gain, metabolic rate, caloric consumption, and blood lipids

1986 • 219 citations

Commitment to abstinence and acute stress in relapse to alcohol, opiates, and nicotine.

1990 • 219 citations

Possible placental origin of ACTH in normal human pregnancy

1975 • 217 citations

Transmitter systems involved in neural plasticity undelying increased anxiety and defense— Implications for understanding anxiety following traumatic stress

1997 • 217 citations

Mental health of teenagers who use cannabis

2002 • 215 citations

Cannabinoid Addiction: Behavioral Models and Neural Correlates

2002 • 213 citations

Stress reinstates nicotine seeking but not sucrose solution seeking in rats

1999 • 208 citations

In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats

1999 • 208 citations

The corticotropin-releasing hormone stimulation test in patients with panic disorder

1986 • 207 citations

Comorbid Cigarette and Alcohol Addiction

1998 • 206 citations

Two-year posttreatment functioning and coping of substance abuse patients with posttraumatic stress disorder.

1999 • 205 citations

Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents

1998 • 205 citations

Corticosteroid Receptor Function Is Decreased in Depressed Patients

1997 • 204 citations

Involvement of Nicotinic Receptors in Alcohol Self‐Administration

2000 • 203 citations

Urges to smoke during the first month of abstinence: relationship to relapse and predictors

1995 • 203 citations

Sex differences in the effects of stressful life events on changes in smoking status

2003 • 196 citations

Major Depressive Disorder, Suicidal Ideation, and Suicide Attempt inTwins Discordant for Cannabis Dependence and Early-Onset Cannabis Use

2004 • 194 citations

Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain

1999 • 192 citations

Opponent Process Model and Psychostimulant Addiction

1997 • 191 citations

The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine

1993 • 190 citations

Corticotropin-releasing factor modulates defensive-withdrawal and exploratory behavior in rats.

1989 • 190 citations

IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY

1984 • 188 citations

Role of CRF 1 and CRF 2 receptors in fear and anxiety

2001 • 188 citations

Effects of transgenic overproduction of CRH on anxiety-like behaviour

2002 • 187 citations

Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I

1995 • 186 citations

High-priority communication I Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

2003 • 185 citations

Neurobiological mechanisms in human anxiety evidence supporting central noradrenergic hyperactivity

1983 • 184 citations

The ACTH Response to Dexamethasone in PTSD

2004 • 181 citations

Specific high-affinity binding protein for human corticotropin-releasing hormone in normal human plasma

1987 • 181 citations

Tobacco smoking: A comparison between alcohol and drug abuse inpatients

1988 • 180 citations

Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy.

1993 • 179 citations

Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.

1994 • 178 citations

Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress

2003 • 175 citations

Dexamethasone suppression test in schizophrenia: Relationship to symptomatology, ventricular enlargement, and outcome

1991 • 171 citations

Corticotropin-releasing factor modulates defensive-withdrawal and exploratory behavior in rats.

1989 • 171 citations

Depressive affect and endocrine functions; blood levels of adrenal cortex and thyroid hormones in patients suffering from depressive reactions.

1957 • 170 citations

Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors

2003 • 169 citations

Urocortin, a novel neuropeptide with anxiogenic-like properties

1997 • 168 citations

Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction

1996 • 168 citations

Nicotine increases alcohol self-administration and reinstates alcohol seeking in rats

2003 • 166 citations

Cessation from cigarette smoking: Changes in body weight, body composition, resting metabolism, and energy consumption

1991 • 162 citations

Response to social stress, urge to smoke, and smoking cessation

2002 • 159 citations

Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.

1996 • 158 citations

Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II

1995 • 156 citations

The anxiolytic effect of the CRH1 receptor antagonist R121919 depends on innate emotionality in rats

2001 • 155 citations

A ‘crash’ course on psychostimulant withdrawal as a model of depression

2002 • 154 citations

Abstinence symptoms during withdrawal from chronic marijuana use.

2000 • 152 citations

Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder

2001 • 152 citations

Effects of social stress on operant drinking of alcoholics and social drinkers

1974 • 152 citations

Isolation of the human plasma corticotrophin-releasing factor-binding protein

1989 • 150 citations

Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001.

1999 • 148 citations

Normalization of dexamethasone suppression test: a laboratory index of recovery from endogenous depression.

1980 • 147 citations

Abstinence symptoms during withdrawal from chronic marijuana use.

2000 • 146 citations

Depressive Affect and Endocrine Functions

1957 • 146 citations

Addiction and schizophrenia

2000 • 144 citations

Pharmacological Evidence Supporting a Role for Central Corticotropin-Releasing Factor2 Receptors in Behavioral, but not Endocrine, Response to Environmental Stress

2002 • 143 citations

The relationship between cannabis use, depression and anxiety among Australian adults: findings from the National Survey of Mental Health and Well-Being

2001 • 143 citations

Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide

2002 • 141 citations

Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

1996 • 141 citations

Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist

2003 • 141 citations

The role of smoking in the regulation of energy balance.

1984 • 140 citations

Alcohol withdrawal symptoms and drinking behavior.

1977 • 140 citations

New vistas in neuropeptide research in neuropsychiatry: focus on corticotropin-releasing factor.

1992 • 139 citations

Changes in aggressive behavior during withdrawal from long-term marijuana use

1999 • 138 citations

Corticotropin-releasing factor and type 1 corticotropin-releasing factor receptor messenger RNAs in rat brain and pituitary during "binge"-pattern cocaine administration and chronic withdrawal.

1996 • 136 citations

Psychiatric symptoms in male cannabis users not using other illicit drugs

1998 • 135 citations

CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues

1995 • 135 citations

Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor

1993 • 135 citations

Animal models of alcohol withdrawal.

2000 • 134 citations

Antagonism of CRF2 receptors produces anxiolytic behavior in animal models of anxiety

2001 • 133 citations

Symptomatology in Alcoholics at Various Stages of Abstinence

1985 • 133 citations

Increased Anxiety‐Like Behavior and Ethanol Self‐Administration in Dependent Rats: Reversal via Corticotropin‐Releasing Factor‐2 Receptor Activation

2004 • 132 citations

The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol

2002 • 131 citations

Comorbid anxiety and affective disorder in alcohol-dependent patients seeking treatment: the first Multicentre Study in Germany

2001 • 130 citations

Marijuana use and the risk of Major Depressive Episode

2002 • 129 citations

Nibbling at CRF receptor control of feeding and gastrocolonic motility

2003 • 128 citations

Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression

2003 • 126 citations

Ethanol intake increases during continuous administration of amphetamine and nicotine, but not several other drugs

1983 • 126 citations

HPA axis dysregulation in mice overexpressing corticotropin releasing hormone

2002 • 120 citations

Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat

1989 • 118 citations

Co-occurrent use of cigarettes, alcohol, and coffee in healthy, community-living men and women.

1985 • 117 citations

A SPECIFIC CARRIER SUBSTANCE FOR HUMAN CORTICOTROPHIN RELEASING FACTOR IN LATE GESTATIONAL MATERNAL PLASMA WHICH COULD MASK THE ACTH‐RELEASING ACTIVITY

1988 • 116 citations

Stress induces CRF release in the paraventricular nucleus, and both CRF and GABA release in the amygdala

2004 • 116 citations

Alcohol dependence: a public health perspective

2002 • 116 citations

Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

2003 • 115 citations

Impact of alcohol detoxification on anxiety and depressive symptoms

2002 • 115 citations

Effects of baclofen and nitrendipine on ethanol withdrawal responses in the rat

1991 • 113 citations

Molecular Identification and Analysis of a Novel Human Corticotropin-Releasing Factor (CRF) Receptor: The CRF2 Receptor

1998 • 113 citations

Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression

2004 • 112 citations

Long‐Term Recovery in Alcoholics

1989 • 112 citations

Urocortin III, A Brain Neuropeptide of the Corticotropin‐Releasing Hormone Family: Modulation by Stress and Attenuation of Some Anxiety‐Like Behaviours

2004 • 112 citations

Correlation between the dexamethasone suppression test in depressed patients and clinical response

1984 • 110 citations

Propranolol antagonizes the enhanced conditioned fear produced by corticotropin releasing factor.

1988 • 110 citations

Behavioral and neuroendocrine effects of the selective CRF2 receptor agonists urocortin II and urocortin III

2004 • 109 citations

Central administration of a CRF antagonist blocks the development of stress-induced behavioral sensitization

1990 • 108 citations

Long-lasting stress sensitisation

2000 • 107 citations

The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy.

1993 • 107 citations

Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice

2003 • 107 citations

The effects of smoking on acth and cortisol secretion

1984 • 105 citations

Marijuana and Tobacco

2003 • 105 citations

Major depression associated with earlier alcohol relapse in treated teens with AUD

2004 • 104 citations

Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial

1988 • 102 citations

Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression

2004 • 101 citations

Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders

2004 • 101 citations

Pituitary and Adrenocortical Responses to the Ovine Corticotropin Releasing Hormone in Depressed Patients and Healthy Volunteers

1987 • 97 citations

The effects of melatonin on the behavioural disturbances induced by chronic mild stress in C3H/He mice

1999 • 95 citations

The Abstinent Alcoholic

1962 • 95 citations

Subjective correlates of cigarette-smoking-induced elevations of peripheral beta-endorphin and cortisol

1992 • 94 citations

Chronic infusion of nicotine can increase operant self-administration of alcohol

2001 • 93 citations

Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy

1993 • 93 citations

Corticotropin-releasing factor receptors in rat pituitary gland: autoradiographic localization

1984 • 92 citations

Cerebrospinal fluid neuropeptides in mood disorder and dementia

1992 • 90 citations

Central administration of corticotropin releasing factor induces long-term sensitization to d-amphetamine

1993 • 90 citations

Co-occurrent use of cigarettes, alcohol, and coffee in healthy, community-living men and women.

1985 • 89 citations

Overexpression of corticotropin‐releasing hormone in transgenic mice and chronic stress‐like autonomic and physiological alterations

2002 • 88 citations

The Role of the CRH Type 1 Receptor in Autonomic Responses to Corticotropin- Releasing Hormone in the Rat

2000 • 88 citations

Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal

2001 • 88 citations

Relapse in outpatient treatment for marijuana dependence

2003 • 88 citations

Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects

1996 • 87 citations

Hedonic capacity, cigarette craving, and diminished positive mood

2004 • 87 citations

Neuroadaptations to chronic exposure to drugs of abuse: Relevance to depressive symptomatology seen across psychiatric diagnostic categories

2002 • 85 citations

Weight gain and adipose tissue metabolism after smoking cessation in women

2001 • 83 citations

Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine

1994 • 82 citations

Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat

2002 • 81 citations

Neural sensitization model for multiple chemical sensitivity: overview of theory and empirical evidence

1999 • 81 citations

Distribution and concentration of urocortin, and effect of adrenalectomy on its content in rat hypothalamus

1998 • 80 citations

Morphine and cocaine influence on CRF biosynthesis in the rat central nucleus of amygdala

2003 • 78 citations

Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor

2001 • 78 citations

Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal

1996 • 76 citations

Research Advances in the Understanding and Treatment of Addiction

2003 • 76 citations

The effects of anxiety, substance use and conduct disorders on risk of major depressive disorder

2003 • 76 citations

Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice

2004 • 76 citations

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid

1996 • 76 citations

Risk factors for late relapse in male and female ex-smokers

1988 • 75 citations

Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis

1995 • 74 citations

Predictors of Relapse during Treatment and Treatment Completion among Marijuana-Dependent Adolescents in an Intensive Outpatient Substance Abuse Program

2004 • 73 citations

Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects

1993 • 73 citations

Characterization of Corticotropin-Releasing Hormone Binding Protein in Human Plasma by Chemical Cross-Linking and its Binding during Pregnancy*

1988 • 73 citations

Gender in relation to relapse crisis situations, coping, and outcome among treated alcoholics

1998 • 72 citations

Changes in energy balance following smoking cessation and resumption of smoking in women.

1990 • 72 citations

Hypothalamic‐Pituitary‐Adrenal Axis and Suicide

1986 • 71 citations

Diagnosis of Depression in the 1980s

1981 • 71 citations

Withdrawal from Chronic Phencyclidine Treatment Induces Long-Lasting Depression in Brain Reward Function

2002 • 70 citations

Time-Dependent Alterations in mRNA Expression of Brain Neuropeptides Regulating Energy Balance and Hypothalamo-Pituitary-Adrenal Activity after Withdrawal from Intermittent Morphine Treatment

2004 • 69 citations

CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist

2000 • 69 citations

125I-Antisauvagine-30: a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors

2001 • 66 citations

The action of nicotine on the pituitary-adrenal cortical axis.

1979 • 65 citations

Changes in food reward following smoking cessation: a pharmacogenetic investigation

2004 • 64 citations

Cocaine Abuse and its Treatment

1984 • 64 citations

Chronic Morphine Sensitizes the Brain Norepinephrine System to Corticotropin-Releasing Factor and Stress

2004 • 62 citations

CSF corticotropin-releasing factor-like immunoactivity in chronic pain patients with and without major depression

1988 • 62 citations

Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats

2004 • 61 citations

Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy

2003 • 60 citations

Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder

2000 • 60 citations

Women Gain Weight 1 Year After Smoking Cessation While Dietary Intake Temporarily Increases

1996 • 60 citations

Both corticotropin-releasing factor receptor type 1 and type 2 are involved in stress-induced inhibition of food intake in rats

2004 • 58 citations

Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis

1993 • 57 citations

Altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine

2003 • 56 citations

Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats

2004 • 55 citations

Changes in energy balance following smoking cessation and resumption of smoking in women.

1990 • 55 citations

Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine

2003 • 53 citations

Enhancement of Performance in Multiple Learning Tasks by Corticotropin-Releasing Factor-Binding Protein Ligand Inhibitors

1997 • 53 citations

LONDON'S SKID ROW

1966 • 53 citations

Stress-induced sensitization of CRH-ir but not P-CREB-ir responsivity in the rat central nervous system

2001 • 52 citations

Nicotine withdrawal induces subsensitivity of hypothalamic–pituitary–adrenal axis to stress in rats: implications for precipitation of depression during smoking cessation

2003 • 51 citations

CSF corticotropin-releasing factor is not affected in panic disorder

1993 • 50 citations

Effects of smoking cessation, restrained eating, and motivational states on food intake in the laboratory.

1994 • 50 citations

Psychopathology of alcoholics during withdrawal and early abstinence

2000 • 49 citations

Reduced attention in mice overproducing corticotropin-releasing hormone

2003 • 48 citations

Corticotrophin and corticosterone secretion following Δ1-tetrahydrocannabinol, in intact and in hypothalamic deafferentated male rats

1982 • 48 citations

Differential release of corticotropin-releasing hormone (CRH) in the amygdala during different types of stressors

2002 • 48 citations

Adolescent Drug Addiction Treatment and Weight Gain

2004 • 48 citations

The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy

1993 • 47 citations

Effects of tobacco abstinence on food intake among cigarette smokers.

1993 • 46 citations

Lifetime rates of alcoholism in adults with anxiety, depression, or co-morbid depression/anxiety: a community survey of Ontario

2002 • 45 citations

Drug-Induced Ego States. I. Cocaine: Phenomenology and Implications

1984 • 43 citations

Opiate detoxification with lofexidine

1981 • 41 citations

Clinical profile of comorbid major depression and alcohol use disorders in an initial psychiatric evaluation

1995 • 37 citations

Effects of smoking cessation, restrained eating, and motivational states on food intake in the laboratory.

1994 • 35 citations

Risk Factors for Continued Cigarette Use After Subarachnoid Hemorrhage

2003 • 35 citations

Acute adverse reactions to psychoactive drugs, drug usage, and psychopathology.

1974 • 34 citations

Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans

2000 • 33 citations

Effect of blockade of corticotropin-releasing factor receptors in the median raphe nucleus on stress-induced c-fos mRNA in the rat brain

2003 • 33 citations

Performance-enhancing effects of CRF-BP ligand inhibitors

2001 • 25 citations

Alcoholism and Disruption of the Activity of Deep Cerebral Structures; Clinical-Laboratory Research

1970 • 25 citations

The plasma levels of ACTH following exposure to stress or nicotine.

1983 • 22 citations

Difference of body mass index stratified by the period of smoking cessation from a cross-sectional study

2004 • 20 citations

Effect of multiple time point sampling on the sensitivity of the dexamethasone suppression test

1983 • 17 citations

The late withdrawal symptoms of alcoholic addiction.

1954 • 16 citations

Central Nervous System Peptide Mechanisms in Stress and Depression

1991 • 15 citations

Comorbidity in the interpretation of dexamethasone suppression test results in children: A review and report

1990 • 15 citations

Diagnosis of depression in the 1980s

1981 • 12 citations

Changes in food consumption and body weight associated with smoking cessation across menstrual cycle phase

1997 • 11 citations

Central nervous system peptide mechanisms in stress and depression

1991 • 9 citations

Cited By (0)

Loading...