Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001.

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The Role of the Amygdala in Fear and Anxiety

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Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study

1983 • 1,954 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

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Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

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Physiology and pharmacology of corticotropin-releasing factor.

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Expression cloning of a human corticotropin-releasing-factor receptor.

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Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

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Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus

1983 • 595 citations

Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims

1988 • 547 citations

Catecholaminergic Modulation of Corticotropin-Releasing Factor and Adrenocorticotropin Secretion

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Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary.

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Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.

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Synthetic Competitive Antagonists of Corticotropin-Releasing Factor: Effect on ACTH Secretion in the Rat

1984 • 474 citations

Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study

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CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.

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Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

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Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus

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CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

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Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action

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Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats

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Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat

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Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats

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Anatomical, Physiological, and Behavioral Aspects of Olfactory Bulbectomy in The Rat

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Corticotropin releasing factor (CRF) receptor antagonist blocks activating and ‘anxiogenic’ actions of CRF in the rat

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Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats

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Attenuation of stress-induced behavior by antagonism of corticotropin-releasing factor receptors in the central amygdala in the rat

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Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus

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Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist

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Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress.

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Characterization of a novel and potent corticotropin-releasing factor antagonist in rats.

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Corticotropin-Releasing Hormone

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Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system.

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Autoradiographic Localization of CRF1 and CRF2 Binding Sites in Adult Rat Brain

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Corticotropin-Releasing Factor: Evidence for a Neurotransmitter Role in the Locus ceruleus during Hemodynamic Stress

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Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey

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Stress‐Specific Regulation of Corticotropin Releasing Hormone Receptor Expression in the Paraventricular and Supraoptic Nuclei of the Hypothalamus in the Rat

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Activating and ‘anxiogenic’ effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone

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A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity

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Effect of centrally administered corticotropin releasing factor (CRF) on multiple feeding paradigms

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Restraint-stress-induced changes in exploratory behavior appear to be mediated by norepinephrine-stimulated release of CRF

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A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice

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Some electrophysiological properties of neurones of rat locus coeruleus.

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Synthesis and Oral Efficacy of a 4-(Butylethylamino)pyrrolo[2,3-d]pyrimidine: A Centrally Active Corticotropin-Releasing Factor₁ Receptor Antagonist

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The central role of corticotrophin‐releasing factor (CRF‐41) in psychological stress in rats.

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The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist

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Corticotropin-releasing factor receptors: An overview

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Corticotropin-releasing factor elicits naloxone sensitive stress-like alterations in exploratory behavior in mice

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125I-Tyro-sauvagine: a novel high affinity radioligand for the pharmacological and biochemical study of human corticotropin-releasing factor 2 alpha receptors.

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Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat

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Localization of corticotropin-releasing hormone (CRH) receptor mRNA in adult rat brain by in situ hybridization histochemistry.

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Stress, antidepressant drugs, and the locus coeruleus

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Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats

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CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice

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Rapid Microscale Synthesis, a New Method for Lead Optimization Using Robotics and Solution Phase Chemistry: Application to the Synthesis and Optimization of Corticotropin-Releasing Factor₁Receptor Antagonists

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Differential regulation of type-1 and type-2α corticotropin-releasing hormone receptor mRNA in the hypothalamic paraventricular nucleus of the rat

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Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats

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Interactions of anxiolytic and antidepressant drugs with hormones of the hypothalamic-pituitary-adrenal axis

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Effects of locus coeruleus stimulation on muricide in olfactory bulbectomized and raphe lesioned rats.

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The effects of CRF and α-helical CRF on anxiety in normal and hypophysectomized rats

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Antagonizing effects of VA-045 on reduced activity of rat locus coeruleus neurons following head injury or intravenous injection of clonidine

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Neuropharmacological profile of non peptide CRF1 antagonists, CRA1000 and CRA1001

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