Tolerance to nicotine's effects in the elevated plus-maze and increased anxiety during withdrawal

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Smoking withdrawal symptoms in two weeks of abstinence

1976 • 551 citations

The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

1983 • 457 citations

A Scale to Differentiate between Types of Smoking as Related to the Management of Affect

1969 • 364 citations

Experimental Approaches to Anxiety and Depression

1993 • 358 citations

The Role of the Dorsal Hippocampal Serotonergic and Cholinergic Systems in the Modulation of Anxiety

2000 • 246 citations

Comparative Study of Pre- and Postsynaptic 5-HT_1AReceptor Modulation of Anxiety in Two Ethological Animal Tests

1996 • 229 citations

Characterization of the locomotor stimulant action of nicotine in tolerant rats

1983 • 222 citations

Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test

1993 • 214 citations

Experimental approaches to anxiety and depression

1993 • 192 citations

The actions of nicotine and cocaine in a mouse model of anxiety

1989 • 188 citations

Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus.

1998 • 182 citations

Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus.

1998 • 165 citations

Modulation of behaviour on trials 1 and 2 in the elevated plus-maze test of anxiety after systemic and hippocampal administration of nicotine

1999 • 119 citations

Effects of nicotine withdrawal on central dopaminergic systems

1996 • 108 citations

Chlordiazepoxide loses its anxiolytic action with long-term treatment

1979 • 107 citations

Cigarette Smoking and Abstinence: Comparative Effects Upon Cognitive Task Performance and Mood State over 24 Hours

1996 • 107 citations

Behavioral and Biochemical Manifestations of Mecamylamine-Precipitated Nicotine Withdrawal in the Rat Role of Nicotinic Receptors in the Ventral Tegmental Area

1999 • 102 citations

Neuroendocrine, physiologic, and behavioral responses following intravenous nicotine in nonsmoking healthy volunteers and in patients with alzheimer's disease

1990 • 93 citations

Time-course of changes in the social interaction test of anxiety following acute and chronic administration of nicotine

1999 • 87 citations

Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

2000 • 87 citations

Evidence that tolerance develops to the anxiolytic effect of diazepam in rats

1985 • 86 citations

The septum and the hippocampus differentially mediate anxiolytic effects of R(+)-8-OH-DPAT.

1998 • 83 citations

Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity

1993 • 82 citations

A genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber

1993 • 78 citations

Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT

1994 • 77 citations

Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.

1994 • 75 citations

Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphé reveals differential GABAergic control in two animal tests of anxiety

1998 • 75 citations

Nicotine self-administration and withdrawal: modulation of anxiety in the social interaction test in rats

2000 • 74 citations

Stimulation of hippocampal 5-HT1A receptors causes amnesia and anxiolytic-like but not antidepressant-like effects in the rat

1993 • 73 citations

Stimulation of nicotinic receptors in the lateral septal nucleus increases anxiety

1999 • 71 citations

Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance

1987 • 66 citations

Anxiogenic effects of nicotine in the dorsal hippocampus are mediated by 5-HT1A and not by muscarinic M1 receptors

2000 • 61 citations

Evidence that the median raphé nucleus - dorsal hippocampal pathway mediates diazepam withdrawal-induced anxiety

1997 • 56 citations

Low but not high doses of buspirone reduce the anxiogenic effects of diazepam withdrawal

1991 • 55 citations

Comparative mood states and cognitive skills of cigarette smokers, deprived smokers and nonsmokers

1998 • 53 citations

Rat brain monoamine oxidase A and B inhibitory (tribulin) activity during drug withdrawal anxiety

1995 • 51 citations

The role of 5‐HT_1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration

2000 • 50 citations

Effects of withdrawal from long-term nicotine gum use

1985 • 48 citations

Effect of dose on nicotine's reinforcing, withdrawal-suppression and self-reported effects.

1990 • 48 citations

Studies on the influence of nicotine infusions on mesolimbic dopamine and locomotor responses to nicotine

1994 • 46 citations

Role of hippocampal 5-HT1A receptors on elevated plus maze exploration after a single restraint experience

1996 • 45 citations

Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen

1991 • 43 citations

The effects of short-term smokeless tobacco deprivation on performance

1989 • 42 citations

Effects of chlordiazepoxide, nicotine and d-amphetamine in the rat potentiated startle model of anxiety

1996 • 40 citations

Sensitisation of withdrawal signs following repeated withdrawal from a benzodiazepine: differences between measures of anxiety and seizure sensitivity

1998 • 31 citations

Personality related effects of nicotine, mode of application, and expectancies on performance, emotional states, and desire for smoking

1998 • 30 citations

Nicotine induces disinhibitory behavior in the rat after subchronic peripheral nicotinic acetylcholine receptor blockade

2000 • 26 citations

Dizocilpine does not prevent the development of tolerance to the anxiolytic effects of diazepam in rats

1999 • 25 citations

Stress-induced expression of the c-fos proto-oncogene in the hippocampal formation.

1994 • 21 citations

Short-term rebound anxiolytic effects and long-term changes in platelet benzodiazepine binding after pentylenetetrazole-kindling in two strains of rat

1996 • 19 citations

Neuropharmacology of a new potential anxiolytic compound, F 2692, 1-(3′-trifluoromethyl phenyl) 1, 4-dihydro 3-amino 4-oxo 6-methyl pyridazine

1993 • 13 citations

An analysis of response to nicotine infusion using an automated radiotelemetry system

1994 • 11 citations