BRCA1 Regulates GADD45 through Its Interactions with the OCT-1 and CAAT Motifs

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

1995 • 1,602 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

The molecular biology of the CCAAT-binding factor NF-Y

1999 • 844 citations

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

1998 • 740 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

GADD45 induction of a G ₂ /M cell cycle checkpoint

1999 • 607 citations

Unusual case of Smith‐Lemli‐Opitz syndrome “type II”

1995 • 572 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

2000 • 533 citations

Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

1987 • 516 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

BRCA1 physically associates with p53 and stimulates its transcriptional activity

1998 • 484 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

1999 • 472 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

BRCA1 regulates p53-dependent gene expression

1998 • 376 citations

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1995 • 345 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin

1999 • 276 citations

The genetics of breast and ovarian cancer

1995 • 271 citations

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

1991 • 268 citations

BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

1998 • 237 citations

Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

1988 • 234 citations

Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.

1995 • 229 citations

Sequence-Specific Transcriptional Corepressor Function for BRCA1 through a Novel Zinc Finger Protein, ZBRK1

2000 • 228 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

2000 • 225 citations

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

2000 • 217 citations

The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression

2000 • 204 citations

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes

2000 • 200 citations

Two regulatory elements for immunoglobulin kappa light chain gene expression.

1984 • 197 citations

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

1999 • 192 citations

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

1998 • 152 citations

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

2000 • 148 citations

Induction of apoptosis by the tumor suppressor protein BRCA1.

1996 • 140 citations

Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage

2001 • 108 citations

Purified octamer binding transcription factors stimulate RNA polymerase III-mediated transcription of the 7SK RNA gene

1989 • 108 citations

BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteins

1998 • 100 citations

Abrogation of p53 Function Affects gadd Gene Responses to DNA Base-Damaging Agents and Starvation

1996 • 98 citations

BRCA1 activation of the GADD45 promoter

2000 • 91 citations

Activation of the transcription factor Oct-1 in response to DNA damage.

2000 • 83 citations

The Cyclin-dependent Kinase-activating Kinase (CAK) Assembly Factor, MAT1, Targets and Enhances CAK Activity on the POU Domains of Octamer Transcription Factors

1997 • 83 citations

A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells.

1997 • 81 citations

Oct-1 Binds Promoter Elements Required for Transcription of the GnRH Gene

1998 • 66 citations

The Central Region of Gadd45 Is Required for Its Interaction with p21/WAF1

2000 • 65 citations

Nuclear Factor Y (NF-Y) and Cellular Senescence

1999 • 63 citations

Histone H2B Gene Transcription during Xenopus Early Development Requires Functional Cooperation between Proteins Bound to the CCAAT and Octamer Motifs

1992 • 46 citations

Conservation of histone H2A/H2B intergene regions: a role for the H2B specific element in divergent transcription

1988 • 40 citations

Octamer-dependent in Vivo Expression of the Endothelial Cell-specific TIE2 Gene

1999 • 31 citations

Rb-Associated Protein 46 (RbAp46) Inhibits Transcriptional Transactivation Mediated by BRCA1

2001 • 29 citations