Pertussis Toxin Inhibition of B Cell and Macrophage Responses to Bacterial Lipopolysaccharide

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 742 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Bacterial Endotoxins and Host Immune Responses

1980 • 629 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.

1978 • 489 citations

Identification of a membrane-associated interleukin 1 in macrophages.

1985 • 487 citations

Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides

1972 • 431 citations

Selective induction of DNA synthesis in T and B lymphocytes

1972 • 411 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

B lymphocyte receptors and polyphosphoinositide degradation

1985 • 332 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization

1985 • 284 citations

The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen.

1975 • 273 citations

Lymphocyte stimulation by protein A of Staphylococcus aureus

1976 • 268 citations

Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

1985 • 197 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis.

1984 • 180 citations

Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis.

1976 • 178 citations

The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies.

1981 • 158 citations

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

1985 • 124 citations

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

1985 • 119 citations

INTERFERON

1975 • 117 citations

Ontogeny of murine B lymphocytes: sequence of B-cell differentiation from surface-immunoglobulin-negative precursors to plasma cells.

1976 • 110 citations

Mitogenic Effect of Bacterial Peptidoglycans Possessing Adjuvant Activity

1975 • 87 citations

Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.

1986 • 85 citations

Functional Subsets of Murine and Human B Lymphocyte Cell Lines

1979 • 82 citations

Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products.

1986 • 74 citations

Suppression of passive cutaneous anaphylaxis by pertussis toxin, an islet-activating protein, as a result of inhibition of histamine release from mast cells

1983 • 58 citations

Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.

1985 • 39 citations

Dual effects of pertussis toxin on lymphoid cells in culture

1986 • 34 citations

Polyclonal B cell stimulation and interleukin 1 induction by the mucoid exopolysaccharide of Pseudomonas aeruginosa associated with cystic fibrosis.

1985 • 30 citations

Characteristics of bacterium GB-2, a presumptiveCytophaga species with novel immunoregulatory properties

1985 • 8 citations