Lipopolysaccharide-mediated signal transduction through phospholipase D activation in monocytic cell lines

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)

1980 • 2,158 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction ¹

1991 • 519 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis

1984 • 228 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Bacterial lipopolysaccharides prime macrophages for enhanced release of arachidonic acid metabolites.

1986 • 211 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.

1987 • 150 citations

Induction of human interleukin 1 by bacterial and synthetic lipid A

1986 • 120 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Signalling properties of lysophosphatidic acid

1993 • 112 citations

Hydroperoxide-Induced Diacylglycerol Formation and Protein Kinase C Activation in Vascular Endothelial Cells

1993 • 109 citations

Activation by bacterial lipopolysaccharide causes changes in the cytosolic free calcium concentration in single peritoneal macrophages.

1991 • 94 citations

Lipopolysaccharide Receptors and Signal Transduction Pathways in Mononuclear Phagocytes

1992 • 72 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.

1988 • 57 citations

Protein kinase C in tumoricidal activation of mouse macrophage cell lines

1991 • 56 citations

Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

1990 • 47 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium.

1993 • 41 citations

Bacterial lipopolysaccharide up-regulates platelet-activating factor-stimulated Ca2+ mobilization and eicosanoid release in human Mono Mac 6 cells.

1992 • 37 citations

Intracellular calcium and pH alterations induced by Escherichia coli endotoxin in rat hepatocytes

1991 • 27 citations

Activation of glomerular mesangial cells by gram-negative bacterial cell wall components.

1988 • 27 citations

Differentiation-linked activation of the respiratory burst in a monocytic cell line (U937) via Fc gamma RII. A study of activation pathways and their regulation.

1991 • 23 citations

Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid

1992 • 20 citations

Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation

1991 • 20 citations

Signal Transduction in Pulmonary Endothelium

1992 • 19 citations

Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells

1991 • 18 citations

Lipid A stimulates phospholipase D activity in rat mesangial cells via a G-protein

1992 • 18 citations

Calcium-Independent Activation of Protein Kinase C by the Dianionic Form of Phosphatidic Acid

1993 • 17 citations

The Effect of Calcium Mobilization on LPS‐Induced IL‐1β Production Depends on the Differentiation Stage of the Monocytes/Macrophages

1992 • 15 citations

Roles of Lipid Turnover in Transmembrane Signal Transduction

1991 • 11 citations