Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes
Data up to Jan 2025
Total Citations Per Year
Abstract
References (64)
THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
1963 • 10,322 citations
Leptin and the regulation of body weight in mammals
1998 • 5,366 citations
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
1997 • 1,891 citations
Anatomy and regulation of the central melanocortin system
2005 • 1,511 citations
Subjective assessment of body fat in live sheep
1969 • 1,419 citations
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
1994 • 1,059 citations
THE TEMPORAL RELATIONSHIP BETWEEN GONADOTROPIN RELEASING HORMONE (GnRH) AND LUTEINIZING HORMONE (LH) SECRETION IN OVARIECTOMIZED EWES1
1982 • 905 citations
A Complete Protocol forIn SituHybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes
1989 • 883 citations
Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus
1997 • 731 citations
Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition
2005 • 535 citations
Stimulation of food intake by muscimol and beta endorphin
1977 • 532 citations
Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin
1998 • 518 citations
Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*
1997 • 456 citations
AgRP(83–132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor
2001 • 375 citations
Level of nutrition affects leptin concentrations in plasma and cerebrospinal fluid in sheep
2000 • 330 citations
Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity
2002 • 302 citations
The Stimulatory Effect of Leptin on the Neuroendocrine Reproductive Axis of the Monkey1
1998 • 297 citations
Do gonadotropin-releasing hormone, tyrosine hydroxylase-, and beta-endorphin-immunoreactive neurons contain estrogen receptors? A double-label immunocytochemical study in the Suffolk ewe.
1993 • 243 citations
Evidence That Dynorphin Plays a Major Role in Mediating Progesterone Negative Feedback on Gonadotropin-Releasing Hormone Neurons in Sheep
2004 • 235 citations
Leptin Regulation of Agrp and Npy mRNA in the Rat Hypothalamus
2001 • 218 citations
A Subset of β-Endorphin- or Dynorphin-Containing Neurons in the Medial Basal Hypothalamus Accumulates Estradiol
1985 • 166 citations
Acetylation alters the feeding response to MSH and beta-endorphin
1989 • 163 citations
Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight
2001 • 162 citations
Regulation of gonadotrophin secretion in rams from birth to sexual maturity
1976 • 161 citations
Effects of Endogenous Opioid Peptides and Opiates on Luteinizing Hormone and Prolactin Secretion in Ovariectomized Rats
1985 • 155 citations
Neuropeptide Signaling in the Integration of Metabolism and Reproduction
2007 • 154 citations
Leptin and reproduction
1999 • 150 citations
Increased Gonadotropin-Releasing Hormone Pulse Frequency Associated with Estrogen-Induced Luteinizing Hormone Surges in Ovariectomized Ewes*
1985 • 145 citations
Influence of Food Restriction on Neuropeptide-Y, Proopiomelanocortin, and Luteinizing Hormone-Releasing Hormone Gene Expression in Sheep Hypothalami1
1993 • 137 citations
Investigation of the melanocyte stimulating hormones on food intake
2000 • 124 citations
Leptin directly acts within the hypothalamus to stimulate gonadotropin‐releasing hormone secretion in vivo in rats
2002 • 119 citations
Neuropeptide Processing and Its Impact on Melanocortin Pathways
2007 • 113 citations
Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction
2000 • 94 citations
Synthesis and secretion of GnRH
2005 • 89 citations
The Melanocortin 4 Receptor Mediates Leptin Stimulation of Luteinizing Hormone and Prolactin Surges in Steroid-Primed Ovariectomized Rats
1999 • 87 citations
Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus
2001 • 86 citations
Long-Term Alterations in Adiposity Affect the Expression of Melanin-Concentrating Hormone and Enkephalin But Not Proopiomelanocortin in the Hypothalamus of Ovariectomized Ewes1
2000 • 82 citations
N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin
2004 • 67 citations
Changes in Expression of the Genes for the Leptin Receptor and the Growth Hormone‐Releasing Peptide/Ghrelin Receptor in the Hypothalamic Arcuate Nucleus with Long‐Term Manipulation of Adiposity by Dietary Means
2005 • 63 citations
The Distribution of Progesterone Receptor Immunoreactivity and mRNA in the Preoptic Area and Hypothalamus of the Ewe: Upregulation of Progesterone Receptor mRNA in the Mediobasal Hypothalamus by Oestrogen
2000 • 59 citations
Changes in Insulin, Glucose and Ketone Bodies, But Not Leptin or Body Fat Content Precede Restoration of Luteinising Hormone Secretion in Ewes
2007 • 52 citations
Profiling Postprandial Thermogenesis in Muscle and Fat of Sheep and the Central Effect of Leptin Administration
2007 • 51 citations
Blood-Brain Leptin Transport and Appetite and Reproductive Neuroendocrine Responses to Intracerebroventricular Leptin Injection in Sheep: Influence of Photoperiod
2006 • 51 citations
Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep
2001 • 50 citations
Regulation of gonadotrophin secretion in rams from birth to sexual maturity
1976 • 48 citations
Plasma beta‐endorphin and adrenocorticotrophin in young horses in training
1991 • 48 citations
Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes.
1996 • 48 citations
Neuropeptide Y (NPY) Delays the Oestrogen‐Induced Luteinizing Hormone (LH) Surge in the Ovariectomized Ewe: Further Evidence That NPY has a Predominant Negative Effect on LH Secretion in the Ewe
2003 • 46 citations
Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
2001 • 41 citations
Y2 Receptor-Selective Agonist Delays the Estrogen-Induced Luteinizing Hormone Surge in Ovariectomized Ewes, but Y1-Receptor-Selective Agonist Stimulates Voluntary Food Intake
2004 • 37 citations
Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1 beta, and neuropeptide-K, may involve excitatory amino acids.
1993 • 33 citations
Effects of vasopressin and elimination of corticotropin-releasing hormone-target cells on pro-opiomelanocortin mRNA levels and adrenocorticotropin secretion in ovine anterior pituitary cells
1997 • 32 citations
Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain
1991 • 28 citations
Long-term alterations in body weight do not affect the expression of melanocortin receptor-3 and -4 mRNA in the ovine hypothalamus
2001 • 26 citations
Adenosine A2A Receptor Gene Disruption Provokes Marked Changes in Melanocortin Content and Pro‐Opiomelanocortin Gene Expression
2003 • 26 citations
Seasonal and steroid-dependent effects on the modulation of LH secretion in the ewe by intracerebroventricularly administered β-endorphin or naloxone
1989 • 24 citations
Evidence for an interaction between α-MSH and opioids in the regulation of gonadotropin secretion in man
1997 • 23 citations
Proceedings of the Australian Physiological and Pharmacological Society Symposium: The Hypothalamus LEPTIN AND THE REGULATION OF FOOD INTAKE AND THE NEUROENDOCRINE AXIS IN SHEEP
2001 • 20 citations
Characterization of α-melanocyte-stimulating hormone (α-MSH)-like peptides in discrete regions of the rat brain. In vitro release of α-MSH from perifused hypothalamus and amygdala
1990 • 17 citations
γ‐MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo
2003 • 13 citations
Disappearance of Opioidergic Tone on LH Secretion in Underfed Prepubertal Sheep
1990 • 12 citations
Microsequencing evidence for the maturation of human proopiomelanocortin into an 18 amino acid β-melanocyte stimulating hormone [hβMSH(5–22)] in nonpituitary tissue
1989 • 10 citations
Radioimmunoassay for ovine FSH.
1972 • 10 citations
Beta-lipotropin precursor of beta-MSH and beta-endorphin.
1979 • 3 citations