Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Leptin is a metabolic signal to the reproductive system.

1996 • 1,037 citations

OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

1950 • 1,020 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

1997 • 670 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

1998 • 518 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Intracerebroventricular injections in mice

1986 • 388 citations

Expression of Functional Leptin Receptors in the Human Ovary1

1997 • 359 citations

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

1995 • 345 citations

Localization of Leptin Receptor mRNA Splice Variants in Murine Peripheral Tissues by RT-PCR andin SituHybridization

1997 • 300 citations

The Stimulatory Effect of Leptin on the Neuroendocrine Reproductive Axis of the Monkey¹

1998 • 297 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 296 citations

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

1995 • 290 citations

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

1998 • 279 citations

Reproductive Hormonal Function in the Genetically Obese (ob/ob) Mouse

1976 • 217 citations

Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice

1997 • 203 citations

Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling*

1999 • 202 citations

α-Melanocyte Stimulating Hormone in the Modulation of Host Reactions*

1993 • 201 citations

Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system

1998 • 192 citations

Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

1998 • 179 citations

Luteinizing hormone and testosterone secretion in young and old male mice

1982 • 162 citations

Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats

1997 • 158 citations

Chronic Administration of Leptin into the Lateral Ventricle Induces Sexual Maturation in Severely Food‐restricted Female Rats

1998 • 139 citations

Fate of Leptin after Intracerebroventricular Injection into the Mouse Brain

1998 • 116 citations

Negative Feedback Control of LH by Testosterone: A Quantitative Study in Male Rats1¹

1976 • 103 citations

Antipyretic Role of Endogenous Melanocortins Mediated by Central Melanocortin Receptors during Endotoxin-Induced Fever

1997 • 98 citations

Selectivity of Cyclic [d-Nal7] and [d-Phe7] Substituted MSH Analogues for the Melanocortin Receptor Subtypes

1997 • 89 citations

The Melanocortin 4 Receptor Mediates Leptin Stimulation of Luteinizing Hormone and Prolactin Surges in Steroid-Primed Ovariectomized Rats

1999 • 87 citations

Effects of MSH on food intake, body weight and coat color of the yellow obese mouse

1989 • 67 citations

A Significant Role of Leptin in the Generation of Steroid-Induced Luteinizing Hormone and Prolactin Surges in Female Rats

1999 • 50 citations

Upregulation of Leptin Receptor Gene Expression in the Anterior Pituitary of Human Growth Hormone-Releasing Hormone Transgenic Mice

1998 • 43 citations

A central action of α-melanocyte-stimulating hormone on serum levels of LH and prolactin in rats

1990 • 38 citations

Progressive infertility in female lethal yellow mice (Ay/a; strain C57BL/6J)

1986 • 35 citations

Physiological role of alpha-melanocyte-stimulating hormone in modulating the secretion of prolactin and luteinizing hormone in the female rat.

1984 • 34 citations

Evidence for an interaction between α-MSH and opioids in the regulation of gonadotropin secretion in man

1997 • 23 citations

α-Melanocyte-stimulating hormone (MSH) and [Nle4, D-Phe7]-α-MSH: Effects on core temperature in rats

1993 • 18 citations