Stromal Reaction to Invasive Cancer: The Cellular Origin of the Myofibroblast and Implications for Tumor Development

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Regulation of differentiation of vascular smooth muscle cells

1995 • 1,681 citations

A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.

1986 • 1,644 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Identification and characterization of a fibroblast marker: FSP1.

1995 • 1,050 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Histology for Pathologists

1992 • 820 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

At least six different actins are expressed in a higher mammal: An analysis based on the amino acid sequence of the amino-terminal tryptic peptide

1978 • 738 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

Contraction of Granulation Tissue in vitro: Similarity to Smooth Muscle

1971 • 569 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

Molecular insights into cancer invasion: strategies for prevention and intervention.

1995 • 500 citations

Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins.

1989 • 473 citations

Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.

1991 • 461 citations

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.

1991 • 449 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

1990 • 417 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Which parts of the road guide steering?

1995 • 401 citations

Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

1988 • 400 citations

Microvascular pericytes contain muscle and nonmuscle actins.

1985 • 399 citations

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

1983 • 393 citations

Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.

1994 • 392 citations

Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition

1989 • 386 citations

Heterogeneity of microvascular pericytes for smooth muscle type alpha-actin.

1991 • 385 citations

Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes

1985 • 378 citations

Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes.

1989 • 367 citations

Isoform-specific 3'-untranslated sequences sort alpha-cardiac and beta- cytoplasmic actin messenger RNAs to different cytoplasmic compartments [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 2):following 1907]

1993 • 332 citations

Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing.

1978 • 328 citations

Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue.

1993 • 320 citations

Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues

1988 • 319 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Dependence of collagen remodelling on α‐smooth muscle actin expression by fibroblasts

1994 • 275 citations

HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues.

1987 • 258 citations

Monoclonal antibody PAL-E specific for endothelium.

1985 • 251 citations

Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall.

1988 • 245 citations

The functional importance of multiple actin isoforms

1990 • 239 citations

Actin Typing on Total Cellular Extracts

1981 • 234 citations

Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds.

1990 • 226 citations

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

1991 • 217 citations

Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.

1985 • 211 citations

The versatility of microvascular pericytes: from mesenchyme to smooth muscle?

1993 • 210 citations

A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts.

1996 • 209 citations

α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

1992 • 209 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Differential distribution of tenascin in the normal, hyperplastic, and neoplastic breast.

1990 • 190 citations

Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1.

1994 • 184 citations

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

1987 • 181 citations

Effects of transforming growth factor-beta 1 on human arterial smooth muscle cells in vitro.

1991 • 171 citations

TGF-β1 induces lens cells to accumulate α-smooth muscle actin, a marker for subcapsular cataracts

1994 • 171 citations

Beta and gamma actin mRNAs are differentially located within myoblasts

1993 • 169 citations

Actin-binding proteins

1990 • 164 citations

Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non‐invasive areas

1992 • 158 citations

Actin-isoform pattern as a marker of normal or pathological smooth-muscle and fibroblastic tissues

1987 • 156 citations

Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts

1991 • 154 citations

Myofibroblasts in the stroma of invasive and metastatic carcinoma A possible host response to neoplasia

1979 • 146 citations

Functional sorting of actin isoforms in microvascular pericytes.

1989 • 136 citations

Smooth muscle α-actin is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells

1985 • 136 citations

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

1988 • 135 citations

Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts.

1992 • 133 citations

Differentiated vascular myocytes: are they involved in neointimal formation?

1996 • 131 citations

Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertropic scar. An immunofluorescence study.

1988 • 122 citations

Production of PDGF‐like growth factor by breast cancer cell lines

1985 • 120 citations

In vivo and in vitro invasiveness of a rat colon‐cancer cell line maintaining E‐cadherin expression: An enhancing role of tumor‐associated myofibroblasts

1994 • 115 citations

Appearance of alpha-smooth muscle actin in human eye lens cells of anterior capsular cataract and in cultured bovine lens-forming cells

1990 • 114 citations

Platelet-derived growth factor regulates actin isoform expression and growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cells

1990 • 114 citations

Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma.

1983 • 110 citations

Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

1996 • 110 citations

Modulation of fibroblastic cytoskeletal features during pathological situations: The role of extracellular matrix and cytokines

1994 • 108 citations

Analysis of α-smooth-muscle actin mRNA expression in rat aortic smooth-muscle cells using a specific cDNA probe

1987 • 103 citations

Clonal heterogeneity in fibroblast phenotype: Implications for the control of epithelial‐mesenchymal interactions

1987 • 103 citations

Stromal myofibroblasts in primary invasive and metastatic carcinomas

1981 • 93 citations

Myofibroblastic stromal reaction in carcinoma of the breast: variations of collagenous matrix and structural glycoproteins

1985 • 93 citations

Myosin heavy‐chain isoforms in adult and developing rabbit vascular smooth muscle

1989 • 93 citations

Structure of a human smooth muscle actin gene (aortic type) with a unique intron site.

1984 • 91 citations

Mitogenicity of human fibroblasts in vivo for human breast cancer cells

1987 • 89 citations

Changes in the extracellular matrix of the normal human breast during the menstrual cycle

1992 • 88 citations

Increased invasion and spontaneous metastasis of BL6 melanoma with inhibition of the desmoplastic response in C57 BL/6 mice.

1987 • 86 citations

Myofibroblast-derived smooth muscle cells during remodelling of rabbit urinary bladder wall induced by partial outflow obstruction.

1993 • 84 citations

Stromal influences on breast cancer cell growth

1992 • 83 citations

Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity of MCF-7 cells in culture

1988 • 82 citations

The specific NH2-terminal sequence Ac-EEED of alpha-smooth muscle actin plays a role in polymerization in vitro and in vivo.

1995 • 82 citations

Stromal aspects of breast carcinoma

1979 • 80 citations

The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer

1995 • 79 citations

Removal of Fibroblasts from Human Epithelial Cell Cultures with Use of a Complement Fixing Monoclonal Antibody Reactive with Human Fibroblasts and Monocytes/Macrophages

1989 • 79 citations

A fibroblast-associated antigen: characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells.

1992 • 78 citations

Human carcinoid cell production of paracrine growth factors that can stimulate fibroblast and endothelial cell growth.

1991 • 73 citations

The role of transforming growth factor beta 1 in the fibroblastic reaction associated with rat colorectal tumor development.

1994 • 70 citations

Preservation of defined phenotypic traits in short-term cultured human breast carcinoma derived epithelial cells.

1987 • 69 citations

Regulation of vimentin expression in cultured human mammary epithelial cells

1990 • 68 citations

Desmoplastic breast carcinoma as a source of human myofibroblasts.

1984 • 68 citations

Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene.

1994 • 67 citations

Smooth muscle differentiation in cultured human breast gland stromal cells.

1990 • 67 citations

β‐actin specific monoclonal antibody

1994 • 67 citations

Paracrine influence of human breast stromal fibroblasts on breast epithelial cells: Secretion of a polypeptide which stimulates reductive 17β‐oestradiol dehydrogenase activity

1988 • 64 citations

Identification, paracrine generation, and possible function of human breast carcinoma myofibroblasts in culture

1992 • 61 citations

Platelet-derived growth factor-induced destabilization of smooth muscle alpha-actin mRNA

1990 • 60 citations

Growth regulation of mouse mammary tumor cells in collagen gel cultures by diffusible factors produced by normal mammary gland epithelium and stromal fibroblasts.

1989 • 60 citations

Intracellular actin as a marker for myofibroblasts in vitro.

1992 • 57 citations

Expression of myosin heavy chain isoforms in mammary epithelial cells and in myofibroblasts from different fibrotic settings during neoplasia

1995 • 55 citations

Cellular components of microvascular proliferation in human glial and metastatic brain neoplasms

1993 • 51 citations

Phenotypic heterogeneity in breast fibroblasts: Functional anomaly in fibroblasts from histologically normal tissue adjacent to carcinoma

1994 • 50 citations

Dipeptidyl peptidase iv expression identifies a functional sub‐population of breast fibroblasts

1992 • 49 citations

Significance of freshly cultured fibroblasts from different tissues in promoting cancer cell growth

1991 • 49 citations

Ectoenzyme regulation by phenotypically distinct fibroblast sub-populations isolated from the human mammary gland

1994 • 47 citations

Nontransformed colony-derived stromal cell lines from normal human marrows. II. Phenotypic characterization and differentiation pathway.

1995 • 46 citations

Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue

1994 • 43 citations

Comparative growth dynamics and morphology between cultured myofibroblasts from granulating wounds and dermal fibroblasts.

1984 • 40 citations

Instability of the myofibroblast phenotype in culture

1990 • 38 citations

Effects of transforming growth factor-beta released from gastric carcinoma cells on the contraction of collagen-matrix gels containing fibroblasts.

1991 • 38 citations

The monoclonal antibody GB 42 ? a useful marker for the differentiation of myofibroblasts

1995 • 37 citations

Heparin decreases the rate of proliferation of rat vascular smooth muscle cells by releasing transforming growth factor -like activity from serum

1993 • 34 citations

In Vitro Expression of the α-Smooth Muscle Actin Isoform by Rat Lung Mesenchymal Cells: Regulation by Culture Condition and Transforming Growth Factor-β

1993 • 34 citations

Fibroblast stimulation of breast cancer cell growth in a serum-free system

1993 • 31 citations

Synchronous appearance of fibronectin, integrin ?5?1, vinculin and actin in epithelial cells and fibroblasts during rat tracheal wound healing

1994 • 31 citations

Possible Derivation from Macrophages in Xanthogranuloma

1989 • 29 citations

Cytoskeleton of liver perisinusoidal cells (lipocytes) in normal and pathological conditions

1992 • 26 citations

Cultured Myofibroblasts: A Useful Model to Study Wound Contraction and Pathological Contracture

1985 • 26 citations

Fibroblast‐dependent tumorigenicity of melanoma xenografts in athymic mice

1992 • 21 citations

Action of general and α-smooth muscle-specific actin antibody microinjection on stress fibers of cultured smooth muscle cells

1990 • 21 citations

Effects of lymphocytes and fibroblasts on the growth of human mammary carcinoma cells studied in short-term primary cultures

1993 • 20 citations

Uncontrolled Growth of Tumour Stromal Fibroblasts in vitro

1983 • 17 citations

Structure of 3'-downstream segment of the human smooth muscle (aortic-type) α-actin-encoding gene and isolation of the specific DNA probe

1989 • 14 citations

Interactions between tumoral MCF7 cells and fibroblasts on matrigel and purified laminin.

1993 • 14 citations

Interactions Between Tumoral MCF7 Cells and Fibroblastson Matrigeland Purified Laminin

1993 • 13 citations

Distribution of the major connective matrix components of the stromal reaction in breast carcinoma. An immunohistochemical study.

1987 • 12 citations

The Microenvironment of the Breast: Three-Dimensional Models to Study the Roles of the Stroma and the Extracellular Matrix in Function and Dysfunction

1995 • 12 citations

Differential influence of stromal fibroblasts from different breast tissues on human breast tumour cell growth in nude mice.

1993 • 12 citations

Molecular Analysis of Bovine Actin Gene and Pseudogene Sequences: Expression of Nonmuscle and Striated Muscle Isoforms in Adult Tissues

1995 • 6 citations

Smooth Muscle α-Actin Downregulation in Cultured Chick Aortic Smooth Muscle and Neural Crest Cells Is Associated with Altered Cell Shape

1996 • 2 citations