Regulation of the Fibroblast Growth Factor Receptor 3 Promoter and Intron I Enhancer by Sp1 Family Transcription Factors

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Basic local alignment search tool

1990 • 87,358 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1995 • 2,642 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

1997 • 1,258 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

TRANSFAC: a database on transcription factors and their DNA binding sites

1996 • 1,057 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

1996 • 867 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

Xenopus embryos regulate the nuclear localization of XMyoD.

1994 • 648 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

1996 • 500 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Transcription by RNA polymerase II: initiator‐directed formation of transcription‐competent complexes ¹

1992 • 412 citations

DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.

1991 • 348 citations

Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia.

1996 • 302 citations

Fibroblast-growth-factor receptor mutations in human skeletal disorders

1995 • 300 citations

Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains

1997 • 284 citations

Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

1990 • 270 citations

Functions of fibroblast growth factors and their receptors

1995 • 254 citations

DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement.

1991 • 254 citations

Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro.

1992 • 254 citations

Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor.

1990 • 243 citations

A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1

1997 • 228 citations

Of Worms and Men: An Evolutionary Perspective on the Fibroblast Growth Factor (FGF) and FGF Receptor Families

1997 • 211 citations

Modulation of epidermal growth factor receptor proto-oncogene transcription by a promoter site sensitive to S1 nuclease.

1988 • 143 citations

Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat.

1993 • 124 citations

Control of Fibroblast Growth Factor Receptor Kinase Signal Transduction by Heterodimerization of Combinatorial Splice Variants

1993 • 124 citations

Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter

1989 • 123 citations

Members of the Sp Transcription Factor Family Control Transcription from the Uteroglobin Promoter

1995 • 107 citations

Alternative splicing generates at least five different isoforms of the human basic-FGF receptor.

1991 • 104 citations

Transgene detection in unpurified mouse tail DNA by polymerase chain reaction.

1991 • 104 citations

Synergistic Induction of Osteocalcin Gene Expression

1996 • 100 citations

Transcriptional Regulation of the SIS/PDGF-B Gene in Human Osteosarcoma Cells by the Sp Family of Transcription Factors

1996 • 99 citations

Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs.

1994 • 98 citations

Mechanisms of transcriptional activation: differences and similarities between yeast, Drosophila, and man

1997 • 92 citations

Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter.

1994 • 80 citations

Genomic Organization of the Human Fibroblast Growth Factor Receptor 3 (FGFR3) Gene and Comparative Sequence Analysis with the MouseFgfr3Gene

1997 • 80 citations

Regulation of Pdha-2 Expression Is Mediated by Proximal Promoter Sequences and CpG Methylation

1997 • 63 citations

Osteonectin Promoter

1989 • 60 citations

Expression of epidermal growth factor family gene members in early mouse development

1994 • 59 citations

The binding of transcription factor Sp1 to multiple sites is required for maximal expression from the rat transforming growth factor alpha promoter.

1992 • 59 citations

Transcription factor Sp1 binds to and activates a human hsp70 gene promoter.

1989 • 58 citations

Suppressor and Activator Functions Mediated by a Repeated Heptad Sequence in the Liver Fatty Acid-binding Protein Gene (Fabpl)

1997 • 40 citations

Morphogenesis: FGF branches out

1997 • 22 citations

Partial characterization of a novel ‘GGA’factor which binds to the osteonectin promoter in bovine bone cells

1993 • 14 citations

Determination of Fibroblast Growth Factor Receptor Expression in Mouse, Rat and Human Samples Using a Single Primer Pair

1997 • 11 citations