Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion

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Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

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Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

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Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

[45] Cytochrome oxidase from beef heart mitochondria

1967 • 1,268 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

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Induction of Nitric Oxide Synthase in Glial Cells

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Nitric oxide neurotoxicity

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Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture

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Requirement for Superoxide in Excitotoxic Cell Death

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[2] Citrate synthase from rat liver

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Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

1990 • 424 citations

Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

1994 • 407 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 • 320 citations

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo

1995 • 283 citations

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 271 citations

Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione

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[40] Preparations of succinate—cytochrome c reductase and the cytochrome b-c1 particle, and reconstitution of succinate-cytochrome c reductase

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Direct Evidence That Excitotoxicity in Cultured Neurons Is Mediated via N‐Methyl‐D‐Aspartate (NMDA) as well as Non‐NMDA Receptors

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Cytotoxic Effect of Brain Macrophages on Developing Neurons

1991 • 191 citations

Glutamate-induced intracellular acidification of cultured hippocampal neurons demonstrates altered energy metabolism resulting from Ca2+ loads

1994 • 152 citations

The role of nitric oxide in multiple sclerosis

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Role of nitric oxide in neurodegenerative diseases

1995 • 108 citations

Cytochrome c oxidase and cardiolipin alterations in response to skeletal muscle ischaemia and reperfusion

1990 • 71 citations

Regulation of Lactate Metabolism by Albumin in Rat Neurons and Astrocytes from Primary Culture

1993 • 57 citations

■ REVIEW : Glial NO: Normal and Pathological Roles

1996 • 54 citations

Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes

1994 • 54 citations

Effects of NO‐Generating Compounds on Synaptosomal Energy Metabolism

1995 • 29 citations

Nitric oxide, energy metabolism and neurological disease

1997 • 27 citations

Rapid decrease in ATP content without recovery phase during glutamate-induced cell death in cultured spinal neurons

1994 • 26 citations

Glycosylphosphatidylinositols: biosynthesis and intracellular transport

1997 • 22 citations