C. elegans SGK-1 Is the Critical Component in the Akt/PKB Kinase Complex to Control Stress Response and Life Span

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

2000 • 1,277 citations

C. Elegans II

1998 • 1,072 citations

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

2001 • 1,013 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

2001 • 907 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

2001 • 850 citations

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

2003 • 782 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

2003 • 644 citations

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1999 • 598 citations

Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi

2002 • 577 citations

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

2001 • 494 citations

Genetic and Environmental Regulation of Dauer Larva Development

1997 • 446 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 • 421 citations

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

1995 • 406 citations

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

2001 • 371 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

The insulin signalling pathway

2002 • 315 citations

Expression of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, Is a Cell Survival Response to Multiple Types of Environmental Stress Stimuli in Mammary Epithelial Cells

2003 • 243 citations

Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span

2002 • 160 citations

Targets of TGF-β Signaling in Caenorhabditis elegans Dauer Formation

2000 • 155 citations

Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like Signaling Pathway

2002 • 110 citations