Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like Signaling Pathway

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

C. elegans: des neurones et des gènes

2003 • 3,047 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

2001 • 1,152 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

The IRS-signalling system: A network of docking proteins that mediate insulin action

1998 • 693 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional Conditions

2002 • 671 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Genes that regulate both development and longevity in Caenorhabditis elegans.

1995 • 579 citations

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1999 • 554 citations

Phosphoinositide kinases

1996 • 529 citations

Untitled

1998 • 523 citations

Interacting genes in nematode dauer larva formation

1981 • 504 citations

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway

2001 • 494 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 • 421 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

1994 • 375 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span

1998 • 362 citations

Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.

1992 • 348 citations

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

1998 • 347 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

2000 • 291 citations

The protein kinases of Caenorhabditis elegans : A model for signal transduction in multicellular organisms

1999 • 277 citations

Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase

2001 • 229 citations

The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling

1998 • 159 citations

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.

1994 • 140 citations

The IRS-1 signaling system

1994 • 95 citations

Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

1994 • 90 citations

The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development

1998 • 76 citations

The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.

1993 • 60 citations

Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits.

1994 • 51 citations

p60 Is an Adaptor for the DrosophilaPhosphoinositide 3-Kinase, Dp110

1997 • 40 citations