Nuclear Appearance of a Factor That Binds the CD28 Response Element within the Interleukin-2 Enhancer Correlates with Interleukin-2 Production

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Monoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes

1980 • 326 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

1986 • 288 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Transcription factor interactions: basics on zippers

1991 • 124 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

Regulation of Interleukin 2 Gene Expression by CD28 Costimulation in Mouse T-Cell Clones: both Nuclear and Cytoplasmic RNAs Are Regulated with Complex Kinetics

1995 • 92 citations

The influence of cyclosporin A on the alternative pathways of human T cell activation in vitro

1989 • 43 citations

Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals

1992 • 38 citations

A cis element required for induction of the interleukin 2 enhancer by human T-cell leukemia virus type I binds a novel Tax-inducible nuclear protein.

1993 • 25 citations

Regulation of IL2 gene transcription via the T-cell accessory molecule CD28

1995 • 9 citations